Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei province
Objective To investigate the effects of family history of hypertension, overweight/obesity and the interaction between the two factors on hypertension in Han and Manchu adults in Hebei Province, so to provide a reference for the prevention and control of hypertension in Hebei province. Methods A cro...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-07-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1053.pdf |
| _version_ | 1827386913621803008 |
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| author | JIANG Chenchen, CUI Ze, PAN Li, SUN Jixin, HE Huijing, HU Yaoda, SHAN Guangliang |
| author_facet | JIANG Chenchen, CUI Ze, PAN Li, SUN Jixin, HE Huijing, HU Yaoda, SHAN Guangliang |
| author_sort | JIANG Chenchen, CUI Ze, PAN Li, SUN Jixin, HE Huijing, HU Yaoda, SHAN Guangliang |
| collection | DOAJ |
| description | Objective To investigate the effects of family history of hypertension, overweight/obesity and the interaction between the two factors on hypertension in Han and Manchu adults in Hebei Province, so to provide a reference for the prevention and control of hypertension in Hebei province. Methods A cross-section survey by questionnaires investigation and physical examination was conducted in Hebei province in July to August 2017, a multistage stratified cluster sampling covering 4 633 Han and Manchu people aged 20-80 years old in Hebei province was performed. A multivariate Logistic regression model was used to analyze the effects of family history of hypertension and overweight/obesity on hypertension. Results After adjusting for ethnicity, sex, age, geographic distribution(urban/rural), economic income,education, smoking, drinking, physical exercise and daily activity, the risk of hypertension was 3.6(95% CI: 2.51-5.18) times higher in those with a family history of hypertension than those without the family history. The risk of hypertension in overweight/obese people was 2.90(95% CI: 1.92-4.37) times higher than non-overweight/obese people. The risk of hypertension was 9.78(95% CI: 6.86-13.95) times higher in population with the factors of overweight plus family history as compared to those with neither factors.The relative excess risk due to interaction (RERI) was 4.28(95% CI: 2.59-5.96), the synergy index (SI) was 1.95(95% CI: 1.54-2.47) and the attributable proportion due to interaction (AP) was 0.44(95% CI: 0.33-0.54). Conclusions Both family history of hypertension and overweight/obesity are associated with an increased risk of hypertension, and there is a positive additive interaction between the two factors. |
| first_indexed | 2024-03-08T15:53:27Z |
| format | Article |
| id | doaj.art-3592569b7bc449b183d5b3f02e614ce4 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T15:53:27Z |
| publishDate | 2023-07-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-3592569b7bc449b183d5b3f02e614ce42024-01-09T03:11:02ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252023-07-014371053105910.16352/j.issn.1001-6325.2023.07.1053Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei provinceJIANG Chenchen, CUI Ze, PAN Li, SUN Jixin, HE Huijing, HU Yaoda, SHAN Guangliang01. Department of Epidemiology and Biostatistics,Institute of Basic Medical Sciences CAMS,School of Basic Medicine PUMC, Beijing 100005;;2. Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050000, ChinaObjective To investigate the effects of family history of hypertension, overweight/obesity and the interaction between the two factors on hypertension in Han and Manchu adults in Hebei Province, so to provide a reference for the prevention and control of hypertension in Hebei province. Methods A cross-section survey by questionnaires investigation and physical examination was conducted in Hebei province in July to August 2017, a multistage stratified cluster sampling covering 4 633 Han and Manchu people aged 20-80 years old in Hebei province was performed. A multivariate Logistic regression model was used to analyze the effects of family history of hypertension and overweight/obesity on hypertension. Results After adjusting for ethnicity, sex, age, geographic distribution(urban/rural), economic income,education, smoking, drinking, physical exercise and daily activity, the risk of hypertension was 3.6(95% CI: 2.51-5.18) times higher in those with a family history of hypertension than those without the family history. The risk of hypertension in overweight/obese people was 2.90(95% CI: 1.92-4.37) times higher than non-overweight/obese people. The risk of hypertension was 9.78(95% CI: 6.86-13.95) times higher in population with the factors of overweight plus family history as compared to those with neither factors.The relative excess risk due to interaction (RERI) was 4.28(95% CI: 2.59-5.96), the synergy index (SI) was 1.95(95% CI: 1.54-2.47) and the attributable proportion due to interaction (AP) was 0.44(95% CI: 0.33-0.54). Conclusions Both family history of hypertension and overweight/obesity are associated with an increased risk of hypertension, and there is a positive additive interaction between the two factors.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1053.pdfhypertension|family history|overweight/obesity|interaction |
| spellingShingle | JIANG Chenchen, CUI Ze, PAN Li, SUN Jixin, HE Huijing, HU Yaoda, SHAN Guangliang Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei province Jichu yixue yu linchuang hypertension|family history|overweight/obesity|interaction |
| title | Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei province |
| title_full | Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei province |
| title_fullStr | Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei province |
| title_full_unstemmed | Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei province |
| title_short | Interaction of family history of hypertension and overweight/obesity on hypertension in Han and Manchu adults in Hebei province |
| title_sort | interaction of family history of hypertension and overweight obesity on hypertension in han and manchu adults in hebei province |
| topic | hypertension|family history|overweight/obesity|interaction |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-43-7-1053.pdf |
| work_keys_str_mv | AT jiangchenchencuizepanlisunjixinhehuijinghuyaodashanguangliang interactionoffamilyhistoryofhypertensionandoverweightobesityonhypertensioninhanandmanchuadultsinhebeiprovince |