Validation of the IPF-specific version of St. George’s Respiratory Questionnaire
Abstract Background Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was developed, but not sufficiently validated. This study aimed to assess the val...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12931-019-1169-9 |
| _version_ | 1828454286882766848 |
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| author | Thomas Skovhus Prior Nils Hoyer Saher Burhan Shaker Jesper Rømhild Davidsen Janelle Yorke Ole Hilberg Elisabeth Bendstrup |
| author_facet | Thomas Skovhus Prior Nils Hoyer Saher Burhan Shaker Jesper Rømhild Davidsen Janelle Yorke Ole Hilberg Elisabeth Bendstrup |
| author_sort | Thomas Skovhus Prior |
| collection | DOAJ |
| description | Abstract Background Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was developed, but not sufficiently validated. This study aimed to assess the validity (i.a. known-groups validity and concurrent validity) and test-retest reliability of SGRQ-I in IPF patients with different disease durations. Methods Patients with IPF were consecutively recruited and completed SGRQ, SGRQ-I, King’s Brief Interstitial Lung Disease questionnaire (K-BILD), University of California, San Diego Shortness of Breath Questionnaire (SOBQ) and Short Form-36 (SF-36) along with pulmonary function tests and a 6-min walk test (6MWT) at baseline. After two weeks, SGRQ-I and Global Rating of Change Scales (GRCS) were completed. Results At baseline and after two weeks, 150 and 134 patients completed the questionnaires, respectively. The internal consistency of SGRQ-I was high (Cronbach’s α = 0.92). Good concurrent validity was demonstrated by high intraclass correlation coefficients (ICC = 0.97), Bland-Altman plots and moderate to strong correlations to K-BILD, SOBQ and SF-36 (r = − 0.46 to 0.80). High ICC (0.92) and a Bland-Altman plot indicated good test-retest reliability. SGRQ-I was good at discriminating between patients with different stages of disease (Δscore > 18.1, effect sizes > 0.10). Validity was similar across groups of different disease duration. Conclusions SGRQ-I proved to be valid at distinguishing between different disease severities, valid compared to other HRQL instruments, applicable across different disease durations and reliable upon repetition. SGRQ-I is a valid option for measuring HRQL in patients with IPF. Trial registration The study was registered at clinicaltrials.org (NCT02818712) on 15 June 2016. |
| first_indexed | 2024-12-11T00:19:30Z |
| format | Article |
| id | doaj.art-359339ff9f3b4a8db53def034146b442 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-11T00:19:30Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-359339ff9f3b4a8db53def034146b4422022-12-22T01:27:48ZengBMCRespiratory Research1465-993X2019-08-0120111010.1186/s12931-019-1169-9Validation of the IPF-specific version of St. George’s Respiratory QuestionnaireThomas Skovhus Prior0Nils Hoyer1Saher Burhan Shaker2Jesper Rømhild Davidsen3Janelle Yorke4Ole Hilberg5Elisabeth Bendstrup6Department of Respiratory Diseases and Allergy, Aarhus University HospitalDepartment of Respiratory Medicine, Herlev-Gentofte University HospitalDepartment of Respiratory Medicine, Herlev-Gentofte University HospitalDepartment of Respiratory Medicine, Odense University HospitalUniversity of Manchester and The Christie NHS Foundation TrustDepartment of Respiratory Medicine, Vejle HospitalDepartment of Respiratory Diseases and Allergy, Aarhus University HospitalAbstract Background Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was developed, but not sufficiently validated. This study aimed to assess the validity (i.a. known-groups validity and concurrent validity) and test-retest reliability of SGRQ-I in IPF patients with different disease durations. Methods Patients with IPF were consecutively recruited and completed SGRQ, SGRQ-I, King’s Brief Interstitial Lung Disease questionnaire (K-BILD), University of California, San Diego Shortness of Breath Questionnaire (SOBQ) and Short Form-36 (SF-36) along with pulmonary function tests and a 6-min walk test (6MWT) at baseline. After two weeks, SGRQ-I and Global Rating of Change Scales (GRCS) were completed. Results At baseline and after two weeks, 150 and 134 patients completed the questionnaires, respectively. The internal consistency of SGRQ-I was high (Cronbach’s α = 0.92). Good concurrent validity was demonstrated by high intraclass correlation coefficients (ICC = 0.97), Bland-Altman plots and moderate to strong correlations to K-BILD, SOBQ and SF-36 (r = − 0.46 to 0.80). High ICC (0.92) and a Bland-Altman plot indicated good test-retest reliability. SGRQ-I was good at discriminating between patients with different stages of disease (Δscore > 18.1, effect sizes > 0.10). Validity was similar across groups of different disease duration. Conclusions SGRQ-I proved to be valid at distinguishing between different disease severities, valid compared to other HRQL instruments, applicable across different disease durations and reliable upon repetition. SGRQ-I is a valid option for measuring HRQL in patients with IPF. Trial registration The study was registered at clinicaltrials.org (NCT02818712) on 15 June 2016.http://link.springer.com/article/10.1186/s12931-019-1169-9Interstitial lung diseaseIdiopathic pulmonary fibrosisHealth-related quality of lifeQuality of lifeIPF-specific version of the St. George’s respiratory questionnaireSGRQ-I |
| spellingShingle | Thomas Skovhus Prior Nils Hoyer Saher Burhan Shaker Jesper Rømhild Davidsen Janelle Yorke Ole Hilberg Elisabeth Bendstrup Validation of the IPF-specific version of St. George’s Respiratory Questionnaire Respiratory Research Interstitial lung disease Idiopathic pulmonary fibrosis Health-related quality of life Quality of life IPF-specific version of the St. George’s respiratory questionnaire SGRQ-I |
| title | Validation of the IPF-specific version of St. George’s Respiratory Questionnaire |
| title_full | Validation of the IPF-specific version of St. George’s Respiratory Questionnaire |
| title_fullStr | Validation of the IPF-specific version of St. George’s Respiratory Questionnaire |
| title_full_unstemmed | Validation of the IPF-specific version of St. George’s Respiratory Questionnaire |
| title_short | Validation of the IPF-specific version of St. George’s Respiratory Questionnaire |
| title_sort | validation of the ipf specific version of st george s respiratory questionnaire |
| topic | Interstitial lung disease Idiopathic pulmonary fibrosis Health-related quality of life Quality of life IPF-specific version of the St. George’s respiratory questionnaire SGRQ-I |
| url | http://link.springer.com/article/10.1186/s12931-019-1169-9 |
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