Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia
Generally, dementia should be considered an acquired syndrome, with multiple possible causes, rather than a specific disease in itself. The leading causes of dementia are neurodegenerative and non-neurodegenerative alterations. Nevertheless, the neurodegenerative group of diseases that lead to cogni...
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/20/7481 |
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| author | Maria Ricci Andrea Cimini Agostino Chiaravalloti Luca Filippi Orazio Schillaci |
| author_facet | Maria Ricci Andrea Cimini Agostino Chiaravalloti Luca Filippi Orazio Schillaci |
| author_sort | Maria Ricci |
| collection | DOAJ |
| description | Generally, dementia should be considered an acquired syndrome, with multiple possible causes, rather than a specific disease in itself. The leading causes of dementia are neurodegenerative and non-neurodegenerative alterations. Nevertheless, the neurodegenerative group of diseases that lead to cognitive impairment and dementia includes multiple possibilities or mixed pathologies with personalized treatment management for each cause, even if Alzheimer’s disease is the most common pathology. Therefore, an accurate differential diagnosis is mandatory in order to select the most appropriate therapy approach. The role of personalized assessment in the treatment of dementia is rapidly growing. Neuroimaging is an essential tool for differential diagnosis of multiple causes of dementia and allows a personalized diagnostic and therapeutic protocol based on risk factors that may improve treatment management, especially in early diagnosis during the prodromal stage. The utility of structural and functional imaging could be increased by standardization of acquisition and analysis methods and by the development of algorithms for automated assessment. The aim of this review is to focus on the most commonly used tracers for differential diagnosis in the dementia field. Particularly, we aim to explore <sup>18</sup>F Fluorodeoxyglucose (FDG) and amyloid positron emission tomography (PET) imaging in Alzheimer’s disease and in other neurodegenerative causes of dementia. |
| first_indexed | 2024-03-10T15:43:15Z |
| format | Article |
| id | doaj.art-35936388c8df45f2afaf15fb5f508f10 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:43:15Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-35936388c8df45f2afaf15fb5f508f102023-11-20T16:36:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012120748110.3390/ijms21207481Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of DementiaMaria Ricci0Andrea Cimini1Agostino Chiaravalloti2Luca Filippi3Orazio Schillaci4Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyNuclear Medicine Section, “Santa Maria Goretti” Hospital, 04100 Latina, ItalyDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, ItalyGenerally, dementia should be considered an acquired syndrome, with multiple possible causes, rather than a specific disease in itself. The leading causes of dementia are neurodegenerative and non-neurodegenerative alterations. Nevertheless, the neurodegenerative group of diseases that lead to cognitive impairment and dementia includes multiple possibilities or mixed pathologies with personalized treatment management for each cause, even if Alzheimer’s disease is the most common pathology. Therefore, an accurate differential diagnosis is mandatory in order to select the most appropriate therapy approach. The role of personalized assessment in the treatment of dementia is rapidly growing. Neuroimaging is an essential tool for differential diagnosis of multiple causes of dementia and allows a personalized diagnostic and therapeutic protocol based on risk factors that may improve treatment management, especially in early diagnosis during the prodromal stage. The utility of structural and functional imaging could be increased by standardization of acquisition and analysis methods and by the development of algorithms for automated assessment. The aim of this review is to focus on the most commonly used tracers for differential diagnosis in the dementia field. Particularly, we aim to explore <sup>18</sup>F Fluorodeoxyglucose (FDG) and amyloid positron emission tomography (PET) imaging in Alzheimer’s disease and in other neurodegenerative causes of dementia.https://www.mdpi.com/1422-0067/21/20/7481Alzheimer’s diseasedementiafrontotemporal dementiaalpha-synucleinopathiesFDG |
| spellingShingle | Maria Ricci Andrea Cimini Agostino Chiaravalloti Luca Filippi Orazio Schillaci Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia International Journal of Molecular Sciences Alzheimer’s disease dementia frontotemporal dementia alpha-synucleinopathies FDG |
| title | Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia |
| title_full | Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia |
| title_fullStr | Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia |
| title_full_unstemmed | Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia |
| title_short | Positron Emission Tomography (PET) and Neuroimaging in the Personalized Approach to Neurodegenerative Causes of Dementia |
| title_sort | positron emission tomography pet and neuroimaging in the personalized approach to neurodegenerative causes of dementia |
| topic | Alzheimer’s disease dementia frontotemporal dementia alpha-synucleinopathies FDG |
| url | https://www.mdpi.com/1422-0067/21/20/7481 |
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