New Approaches in Immunotherapy of Behçet Disease
Behçet Disease (BD) is an autoimmune disorder with recurrent ocular, vascular, central nervous system, articular, mucocutaneous, and gastrointestinal manifestations with unclear etiology and pathogenesis. The further characterization of inflammatory features of Behçet’s disease may eventually lead t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2013-02-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-9.pdf |
| _version_ | 1818118731644010496 |
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| author | Behzad Baradaran Zohreh Babaloo Fatemeh Zare Shahneh Mozhdeh Mohammadian |
| author_facet | Behzad Baradaran Zohreh Babaloo Fatemeh Zare Shahneh Mozhdeh Mohammadian |
| author_sort | Behzad Baradaran |
| collection | DOAJ |
| description | Behçet Disease (BD) is an autoimmune disorder with recurrent ocular, vascular, central nervous system, articular, mucocutaneous, and gastrointestinal manifestations with unclear etiology and pathogenesis. The further characterization of inflammatory features of Behçet’s disease may eventually lead to development of better treatment options. Clinical and laboratory observations suggested an important role of IL-17, IL-21 and neutrophil-mediated process in the pathogenesis of BD. New therapeutic modalities target specific and nonspecific suppression of the immune system. The various non-specific immunosuppressive drugs, used either alone or in combinations, frequently fail to control inflammation or maintain remissions. Due to encouraging clinical results (i.e. Antigenic specification, prolonged survival with acceptable levels of toxicity); antibody-based drugs could be effective for the clinical management of Behçet’s disease. |
| first_indexed | 2024-12-11T04:58:58Z |
| format | Article |
| id | doaj.art-3594d62fc78540d4a0c5276ecdf1fb75 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-11T04:58:58Z |
| publishDate | 2013-02-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-3594d62fc78540d4a0c5276ecdf1fb752022-12-22T01:20:11ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082013-02-013191110.5681/apb.2013.002New Approaches in Immunotherapy of Behçet DiseaseBehzad BaradaranZohreh BabalooFatemeh Zare ShahnehMozhdeh MohammadianBehçet Disease (BD) is an autoimmune disorder with recurrent ocular, vascular, central nervous system, articular, mucocutaneous, and gastrointestinal manifestations with unclear etiology and pathogenesis. The further characterization of inflammatory features of Behçet’s disease may eventually lead to development of better treatment options. Clinical and laboratory observations suggested an important role of IL-17, IL-21 and neutrophil-mediated process in the pathogenesis of BD. New therapeutic modalities target specific and nonspecific suppression of the immune system. The various non-specific immunosuppressive drugs, used either alone or in combinations, frequently fail to control inflammation or maintain remissions. Due to encouraging clinical results (i.e. Antigenic specification, prolonged survival with acceptable levels of toxicity); antibody-based drugs could be effective for the clinical management of Behçet’s disease.http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-9.pdfBehçet diseaseNeutrophilImmunotherapyMonoclonal antibodiesIL-21IL-17 |
| spellingShingle | Behzad Baradaran Zohreh Babaloo Fatemeh Zare Shahneh Mozhdeh Mohammadian New Approaches in Immunotherapy of Behçet Disease Advanced Pharmaceutical Bulletin Behçet disease Neutrophil Immunotherapy Monoclonal antibodies IL-21 IL-17 |
| title | New Approaches in Immunotherapy of Behçet Disease |
| title_full | New Approaches in Immunotherapy of Behçet Disease |
| title_fullStr | New Approaches in Immunotherapy of Behçet Disease |
| title_full_unstemmed | New Approaches in Immunotherapy of Behçet Disease |
| title_short | New Approaches in Immunotherapy of Behçet Disease |
| title_sort | new approaches in immunotherapy of behcet disease |
| topic | Behçet disease Neutrophil Immunotherapy Monoclonal antibodies IL-21 IL-17 |
| url | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-9.pdf |
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