Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies
Introduction Cardiovascular disease (CVD) is a major cause of morbidity and mortality throughout the world. The LIPIDOGRAM2015 study was performed to estimate the prevalence of risk factors for atherosclerotic diseases as well as cardiovascular and related disorders in the primary care setting in Po...
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Termedia Publishing House
2020-06-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Design-and-rationale-of-a-nationwide-screening-analysis-from-the-LIPIDOGRAM2015-and,122779,0,2.html |
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| author | Jacek J. Jóźwiak Sławomir Kasperczyk Tomasz Tomasik Tadeusz Osadnik Adam Windak Krzysztof Studziński Mirosław Mastej Alberico Catapano Kausik K. Ray Dimitri P. Mikhailidis Peter P. Toth George Howard Gregory Y. H. Lip Maciej Tomaszewski Fadi J. Charchar Naveed Sattar Bryan Williams Thomas M. MacDonald Paweł Krzemień Michał Dobrakowski Aleksandra Kasperczyk Dariusz Nowak Łukasz Skowron Żaneta Żak Joanna Lewek Maciej Banach |
| author_facet | Jacek J. Jóźwiak Sławomir Kasperczyk Tomasz Tomasik Tadeusz Osadnik Adam Windak Krzysztof Studziński Mirosław Mastej Alberico Catapano Kausik K. Ray Dimitri P. Mikhailidis Peter P. Toth George Howard Gregory Y. H. Lip Maciej Tomaszewski Fadi J. Charchar Naveed Sattar Bryan Williams Thomas M. MacDonald Paweł Krzemień Michał Dobrakowski Aleksandra Kasperczyk Dariusz Nowak Łukasz Skowron Żaneta Żak Joanna Lewek Maciej Banach |
| author_sort | Jacek J. Jóźwiak |
| collection | DOAJ |
| description | Introduction
Cardiovascular disease (CVD) is a major cause of morbidity and mortality throughout the world. The LIPIDOGRAM2015 study was performed to estimate the prevalence of risk factors for atherosclerotic diseases as well as cardiovascular and related disorders in the primary care setting in Poland. The LIPIDOGEN2015 sub-study was designed to include a random cohort of patients in order to analyse parameters related to lipid metabolism, oxidative stress, inflammatory responses, autoimmune disorders, and gene variants that confer susceptibility to cardiometabolic and atherosclerotic diseases.
Material and methods
The recruitment was carried out by 438 primary care physicians in Poland. The expected number of patients recruited for the LIPIDOGRAM2015 study was 13,000–14,000 with 13–15% (1700–2000) also participating in the LIPIDOGEN2015 sub-study. Each patient had to complete a questionnaire concerning medical and family history, concomitant diseases, and pharmacotherapy. Anthropometric measurements were performed at the doctor’s office. For the LIPIDOGEN2015 sub-study, saliva samples for DNA isolation and blood samples for measurement of glycated haemoglobin, oxidative stress parameters, autoantibody levels, and inflammatory cytokine profile and apolipoprotein profile were collected. Follow-up data will be obtained from the National Health Fund in Poland.
Results
The LIPIDOGRAM2015 and LIPIDOGEN2015 study cohort reflects the prevalence of cardiovascular risk factors and concomitant diseases, markers of oxidative stress, the presence of autoantibodies, inflammatory cytokine profile, and apolipoprotein profile, as well as genetic variants potentially conferring susceptibility to cardiometabolic and atherosclerotic diseases.
Conclusions
This study presents the prevalence of different CV risk factors, with special emphasis on lipid disorders, and it assesses the relationship between inflammation, oxidative stress, and mutations in genes encoding proteins regulating lipid metabolism, as well as genes conferring susceptibility to cardiovascular, cardiometabolic, and related diseases. |
| first_indexed | 2024-12-10T04:52:02Z |
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| id | doaj.art-359558dfd89448a19daf1e7de6010795 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-12-10T04:52:02Z |
| publishDate | 2020-06-01 |
| publisher | Termedia Publishing House |
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| series | Archives of Medical Science |
| spelling | doaj.art-359558dfd89448a19daf1e7de60107952022-12-22T02:01:35ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512020-06-0118360461610.5114/aoms.2020.96052122779Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studiesJacek J. Jóźwiak0Sławomir Kasperczyk1Tomasz Tomasik2Tadeusz Osadnik3Adam Windak4Krzysztof Studziński5Mirosław Mastej6Alberico Catapano7Kausik K. Ray8Dimitri P. Mikhailidis9Peter P. Toth10George Howard11Gregory Y. H. Lip12Maciej Tomaszewski13Fadi J. Charchar14Naveed Sattar15Bryan Williams16Thomas M. MacDonald17Paweł Krzemień18Michał Dobrakowski19Aleksandra Kasperczyk20Dariusz Nowak21Łukasz Skowron22Żaneta Żak23Joanna Lewek24Maciej Banach25Department of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Opole, PolandDepartment of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, PolandChair of Family Medicine, Jagiellonian University Medical College, Krakow, PolandDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, PolandChair of Family Medicine, Jagiellonian University Medical College, Krakow, PolandChair of Family Medicine, Jagiellonian University Medical College, Krakow, PolandMastej Medical Centre, Jasło, PolandDepartment of Pharmacological Sciences University of Milano and Multimedica IRCCS, Milano, ItalyImperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College, Kensington, London, UKDepartment of Clinical Biochemistry, Royal Free Hospital, University College London, London, UKCicarrone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, and CGH Medical Center, Sterling, Illinois, USADepartment of Biostatistics, School of Public Health of Alabama, Birmingham, AL, USALiverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; and Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UKSchool of Health and Life Sciences, Federation University Australia, Ballarat, Victoria, AustraliaInstitute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UKNIHR University College London Biomedical Research Centre, University College London and University College London Hospitals NHS Foundation Trust, London, UKMEMO Research, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UKEuroimmun Polska Sp. z o.o., PolandDepartment of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, PolandDepartment of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, PolandMunicipal Hospital, Czestochowa, PolandDepartment of Gastroenterology and Internal Diseases, Military Institute of Medicine, Warsaw, PolandDepartment of Family Medicine and Public Health, Faculty of Medicine, University of Opole, Opole, PolandPolish Mothers Memorial Hospital Research Institute, Lodz PolandPolish Mothers Memorial Hospital Research Institute, Lodz PolandIntroduction Cardiovascular disease (CVD) is a major cause of morbidity and mortality throughout the world. The LIPIDOGRAM2015 study was performed to estimate the prevalence of risk factors for atherosclerotic diseases as well as cardiovascular and related disorders in the primary care setting in Poland. The LIPIDOGEN2015 sub-study was designed to include a random cohort of patients in order to analyse parameters related to lipid metabolism, oxidative stress, inflammatory responses, autoimmune disorders, and gene variants that confer susceptibility to cardiometabolic and atherosclerotic diseases. Material and methods The recruitment was carried out by 438 primary care physicians in Poland. The expected number of patients recruited for the LIPIDOGRAM2015 study was 13,000–14,000 with 13–15% (1700–2000) also participating in the LIPIDOGEN2015 sub-study. Each patient had to complete a questionnaire concerning medical and family history, concomitant diseases, and pharmacotherapy. Anthropometric measurements were performed at the doctor’s office. For the LIPIDOGEN2015 sub-study, saliva samples for DNA isolation and blood samples for measurement of glycated haemoglobin, oxidative stress parameters, autoantibody levels, and inflammatory cytokine profile and apolipoprotein profile were collected. Follow-up data will be obtained from the National Health Fund in Poland. Results The LIPIDOGRAM2015 and LIPIDOGEN2015 study cohort reflects the prevalence of cardiovascular risk factors and concomitant diseases, markers of oxidative stress, the presence of autoantibodies, inflammatory cytokine profile, and apolipoprotein profile, as well as genetic variants potentially conferring susceptibility to cardiometabolic and atherosclerotic diseases. Conclusions This study presents the prevalence of different CV risk factors, with special emphasis on lipid disorders, and it assesses the relationship between inflammation, oxidative stress, and mutations in genes encoding proteins regulating lipid metabolism, as well as genes conferring susceptibility to cardiovascular, cardiometabolic, and related diseases.https://www.archivesofmedicalscience.com/Design-and-rationale-of-a-nationwide-screening-analysis-from-the-LIPIDOGRAM2015-and,122779,0,2.htmlcardiovascular diseasescardiometabolic diseasesatherosclerosisdyslipidaemiainflammationoxidative stressgenes |
| spellingShingle | Jacek J. Jóźwiak Sławomir Kasperczyk Tomasz Tomasik Tadeusz Osadnik Adam Windak Krzysztof Studziński Mirosław Mastej Alberico Catapano Kausik K. Ray Dimitri P. Mikhailidis Peter P. Toth George Howard Gregory Y. H. Lip Maciej Tomaszewski Fadi J. Charchar Naveed Sattar Bryan Williams Thomas M. MacDonald Paweł Krzemień Michał Dobrakowski Aleksandra Kasperczyk Dariusz Nowak Łukasz Skowron Żaneta Żak Joanna Lewek Maciej Banach Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies Archives of Medical Science cardiovascular diseases cardiometabolic diseases atherosclerosis dyslipidaemia inflammation oxidative stress genes |
| title | Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies |
| title_full | Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies |
| title_fullStr | Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies |
| title_full_unstemmed | Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies |
| title_short | Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies |
| title_sort | design and rationale of a nationwide screening analysis from the lipidogram2015 and lipidogen2015 studies |
| topic | cardiovascular diseases cardiometabolic diseases atherosclerosis dyslipidaemia inflammation oxidative stress genes |
| url | https://www.archivesofmedicalscience.com/Design-and-rationale-of-a-nationwide-screening-analysis-from-the-LIPIDOGRAM2015-and,122779,0,2.html |
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