The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues

The Hydrophobicity and Antifungal Potentiation of Burkholdine Analogues

The burkholdines are a family of cyclic lipopeptides reported to exhibit antifungal activity. We synthesized a series of 18 burkholdine analogues in good yield by conventional Fmoc-SPPS followed by cyclization with DIPCI/HOBt in the solution phase. Although none of the synthesized peptides exhibited...

Full description

Bibliographic Details
Main Authors: Hiroyuki Konno, Mio Sasaki, Hinata Sano, Keima Osawa, Kazuto Nosaka, Shigekazu Yano
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
antifungal activity
cyclic octalipopeptide
burkholdine
potentiation effect
Online Access:https://www.mdpi.com/1420-3049/27/4/1191

Internet

https://www.mdpi.com/1420-3049/27/4/1191

Similar Items