Nuclear Mechanotransduction in Skeletal Muscle
Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that are maintained in a quiescent state in homeostatic conditions. Skeletal muscle is remarkable in its ability to adapt to...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/2/318 |
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| author | Saline Jabre Walid Hleihel Catherine Coirault |
| author_facet | Saline Jabre Walid Hleihel Catherine Coirault |
| author_sort | Saline Jabre |
| collection | DOAJ |
| description | Skeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that are maintained in a quiescent state in homeostatic conditions. Skeletal muscle is remarkable in its ability to adapt to mechanical constraints, a property referred as muscle plasticity and mediated by both MCPs and myofibers. An emerging body of literature supports the notion that muscle plasticity is critically dependent upon nuclear mechanotransduction, which is transduction of exterior physical forces into the nucleus to generate a biological response. Mechanical loading induces nuclear deformation, changes in the nuclear lamina organization, chromatin condensation state, and cell signaling, which ultimately impacts myogenic cell fate decisions. This review summarizes contemporary insights into the mechanisms underlying nuclear force transmission in MCPs and myofibers. We discuss how the cytoskeleton and nuclear reorganizations during myogenic differentiation may affect force transmission and nuclear mechanotransduction. We also discuss how to apply these findings in the context of muscular disorders. Finally, we highlight current gaps in knowledge and opportunities for further research in the field. |
| first_indexed | 2024-03-09T05:45:55Z |
| format | Article |
| id | doaj.art-35989d2d49d94dcd9a78ca9921190e64 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:45:55Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-35989d2d49d94dcd9a78ca9921190e642023-12-03T12:21:19ZengMDPI AGCells2073-44092021-02-0110231810.3390/cells10020318Nuclear Mechanotransduction in Skeletal MuscleSaline Jabre0Walid Hleihel1Catherine Coirault2Sorbonne Université, INSERM UMRS-974 and Institut de Myologie, 75013 Paris, FranceDepartment of Biology, Faculty of Arts and Sciences, Holy Spirit University of Kasik (USEK), Jounieh 446, LebanonSorbonne Université, INSERM UMRS-974 and Institut de Myologie, 75013 Paris, FranceSkeletal muscle is composed of multinucleated, mature muscle cells (myofibers) responsible for contraction, and a resident pool of mononucleated muscle cell precursors (MCPs), that are maintained in a quiescent state in homeostatic conditions. Skeletal muscle is remarkable in its ability to adapt to mechanical constraints, a property referred as muscle plasticity and mediated by both MCPs and myofibers. An emerging body of literature supports the notion that muscle plasticity is critically dependent upon nuclear mechanotransduction, which is transduction of exterior physical forces into the nucleus to generate a biological response. Mechanical loading induces nuclear deformation, changes in the nuclear lamina organization, chromatin condensation state, and cell signaling, which ultimately impacts myogenic cell fate decisions. This review summarizes contemporary insights into the mechanisms underlying nuclear force transmission in MCPs and myofibers. We discuss how the cytoskeleton and nuclear reorganizations during myogenic differentiation may affect force transmission and nuclear mechanotransduction. We also discuss how to apply these findings in the context of muscular disorders. Finally, we highlight current gaps in knowledge and opportunities for further research in the field.https://www.mdpi.com/2073-4409/10/2/318mechanotransductionmuscle disordersnucleusnucleo-cytoplasmic couplingmechanics |
| spellingShingle | Saline Jabre Walid Hleihel Catherine Coirault Nuclear Mechanotransduction in Skeletal Muscle Cells mechanotransduction muscle disorders nucleus nucleo-cytoplasmic coupling mechanics |
| title | Nuclear Mechanotransduction in Skeletal Muscle |
| title_full | Nuclear Mechanotransduction in Skeletal Muscle |
| title_fullStr | Nuclear Mechanotransduction in Skeletal Muscle |
| title_full_unstemmed | Nuclear Mechanotransduction in Skeletal Muscle |
| title_short | Nuclear Mechanotransduction in Skeletal Muscle |
| title_sort | nuclear mechanotransduction in skeletal muscle |
| topic | mechanotransduction muscle disorders nucleus nucleo-cytoplasmic coupling mechanics |
| url | https://www.mdpi.com/2073-4409/10/2/318 |
| work_keys_str_mv | AT salinejabre nuclearmechanotransductioninskeletalmuscle AT walidhleihel nuclearmechanotransductioninskeletalmuscle AT catherinecoirault nuclearmechanotransductioninskeletalmuscle |