Electric stimulation enhances recovery of motor function in spinal cord contused rats
Objective To investigate the effect of nerve electric stimulation on spinal cord contused rats and to explore the appropriate mechanism. Methods Rats were divided into sham group, control group and experimental group. T9 rat spinal cord contusion(SCC) model was developed by Allen's method. Expe...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2020-03-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190401.pdf |
| _version_ | 1797365704727461888 |
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| author | ZENG Xi, ZHAN Qi, GAO Yuan, CUI Nai-hao, FENG Lu-qian |
| author_facet | ZENG Xi, ZHAN Qi, GAO Yuan, CUI Nai-hao, FENG Lu-qian |
| author_sort | ZENG Xi, ZHAN Qi, GAO Yuan, CUI Nai-hao, FENG Lu-qian |
| collection | DOAJ |
| description | Objective To investigate the effect of nerve electric stimulation on spinal cord contused rats and to explore the appropriate mechanism. Methods Rats were divided into sham group, control group and experimental group. T9 rat spinal cord contusion(SCC) model was developed by Allen's method. Experimental group was treated with nerve electric stimulation. After neurobehavioral score assessment, immunohistochemistry and Western blot were used to detect nerve growth factor and nestin. Results After spinal cord injury, score of rats gradually increased,and compared with control group, the experimental group significant increased(P＜0.05) at d 7. The nerve growth factor and nestin expression of experimental group, up-regulated significantly (P＜0.05). Conclusions Nerve electric stimulation may create a microenvironment conducive to neural survival and differentiation, which facilites the recovery of hindlimb motor function in rats. |
| first_indexed | 2024-03-08T16:52:45Z |
| format | Article |
| id | doaj.art-359900e13172451b9772f65b0a0ac505 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:52:45Z |
| publishDate | 2020-03-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-359900e13172451b9772f65b0a0ac5052024-01-05T03:14:14ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252020-03-01403363367Electric stimulation enhances recovery of motor function in spinal cord contused ratsZENG Xi, ZHAN Qi, GAO Yuan, CUI Nai-hao, FENG Lu-qian01. Guizhou Medical University, Guiyang 550004;;2. Department of Neurosurgery, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaObjective To investigate the effect of nerve electric stimulation on spinal cord contused rats and to explore the appropriate mechanism. Methods Rats were divided into sham group, control group and experimental group. T9 rat spinal cord contusion(SCC) model was developed by Allen's method. Experimental group was treated with nerve electric stimulation. After neurobehavioral score assessment, immunohistochemistry and Western blot were used to detect nerve growth factor and nestin. Results After spinal cord injury, score of rats gradually increased,and compared with control group, the experimental group significant increased(P＜0.05) at d 7. The nerve growth factor and nestin expression of experimental group, up-regulated significantly (P＜0.05). Conclusions Nerve electric stimulation may create a microenvironment conducive to neural survival and differentiation, which facilites the recovery of hindlimb motor function in rats.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190401.pdfspinal cord injury|nerve electrical stimulation|nerve growth factor|nestin |
| spellingShingle | ZENG Xi, ZHAN Qi, GAO Yuan, CUI Nai-hao, FENG Lu-qian Electric stimulation enhances recovery of motor function in spinal cord contused rats Jichu yixue yu linchuang spinal cord injury|nerve electrical stimulation|nerve growth factor|nestin |
| title | Electric stimulation enhances recovery of motor function in spinal cord contused rats |
| title_full | Electric stimulation enhances recovery of motor function in spinal cord contused rats |
| title_fullStr | Electric stimulation enhances recovery of motor function in spinal cord contused rats |
| title_full_unstemmed | Electric stimulation enhances recovery of motor function in spinal cord contused rats |
| title_short | Electric stimulation enhances recovery of motor function in spinal cord contused rats |
| title_sort | electric stimulation enhances recovery of motor function in spinal cord contused rats |
| topic | spinal cord injury|nerve electrical stimulation|nerve growth factor|nestin |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190401.pdf |
| work_keys_str_mv | AT zengxizhanqigaoyuancuinaihaofengluqian electricstimulationenhancesrecoveryofmotorfunctioninspinalcordcontusedrats |