Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy
Abstract Background To compare the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal of mCNV around the perforating scleral vessel (PSV). Methods A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up perio...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Eye and Vision |
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| Online Access: | https://doi.org/10.1186/s40662-024-00374-5 |
| _version_ | 1827328592669835264 |
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| author | Xiangjun She Wangjing Yao Gongyu Huang Zhi Liang Jin Xie Jiwei Tao Sulan Wu Jianbo Mao Yiqi Chen Yun Zhang Lijun Shen |
| author_facet | Xiangjun She Wangjing Yao Gongyu Huang Zhi Liang Jin Xie Jiwei Tao Sulan Wu Jianbo Mao Yiqi Chen Yun Zhang Lijun Shen |
| author_sort | Xiangjun She |
| collection | DOAJ |
| description | Abstract Background To compare the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal of mCNV around the perforating scleral vessel (PSV). Methods A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up period. The neovascular signal relationship between PSV and mCNV were classified into the presence of neovascular signal of CNV around PSV or not. The recurrence of mCNV, best-corrected visual acuity (BCVA), hyperreflective foci height, CNV area and CNV flow area were analyzed between two groups. Results Neovascular signal of CNV around PSV was detected in 20 eyes (39.2%). The one-year recurrence rate in the group with neovascular signal of CNV around PSV was significantly higher than that in the group without neovascular signal of CNV around PSV (P = 0.045). The recurrence time in the group with neovascular signal around PSV was shorter than that in the group without neovascular signal around PSV (P = 0.030). Cox proportional hazard model showed that the presence of neovascular signal of CNV around PSV [hazard ratio (HR): 2.904] and subfoveal choroidal thickness ≤ 50 μm (HR: 0.368) were risk factors for recurrence of mCNV. In the group with neovascular signal around PSV, the BCVA was worse (P = 0.024) and the CNV flow area was more unstable (P = 0.027) after therapy. Conclusions PSV was commonly detected in patients with mCNV. The presence of neovascular signal of CNV around PSV was prone to recur with a shorter time in mCNV patients. |
| first_indexed | 2024-03-07T15:19:46Z |
| format | Article |
| id | doaj.art-3599c11c0a3a4b15a3fa91a60fddc280 |
| institution | Directory Open Access Journal |
| issn | 2326-0254 |
| language | English |
| last_indexed | 2024-03-07T15:19:46Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Eye and Vision |
| spelling | doaj.art-3599c11c0a3a4b15a3fa91a60fddc2802024-03-05T17:42:41ZengBMCEye and Vision2326-02542024-02-0111111410.1186/s40662-024-00374-5Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapyXiangjun She0Wangjing Yao1Gongyu Huang2Zhi Liang3Jin Xie4Jiwei Tao5Sulan Wu6Jianbo Mao7Yiqi Chen8Yun Zhang9Lijun Shen10National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical UniversityNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical UniversityNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical UniversityNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical UniversityNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical UniversityNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical UniversityCenter for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical UniversityCenter for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College)Abstract Background To compare the recurrence of myopic choroidal neovascularization (mCNV) based on the neovascular signal of mCNV around the perforating scleral vessel (PSV). Methods A consecutive series of naïve patients with mCNV accepted anti-VEGF therapy with a minimum 12-month follow-up period. The neovascular signal relationship between PSV and mCNV were classified into the presence of neovascular signal of CNV around PSV or not. The recurrence of mCNV, best-corrected visual acuity (BCVA), hyperreflective foci height, CNV area and CNV flow area were analyzed between two groups. Results Neovascular signal of CNV around PSV was detected in 20 eyes (39.2%). The one-year recurrence rate in the group with neovascular signal of CNV around PSV was significantly higher than that in the group without neovascular signal of CNV around PSV (P = 0.045). The recurrence time in the group with neovascular signal around PSV was shorter than that in the group without neovascular signal around PSV (P = 0.030). Cox proportional hazard model showed that the presence of neovascular signal of CNV around PSV [hazard ratio (HR): 2.904] and subfoveal choroidal thickness ≤ 50 μm (HR: 0.368) were risk factors for recurrence of mCNV. In the group with neovascular signal around PSV, the BCVA was worse (P = 0.024) and the CNV flow area was more unstable (P = 0.027) after therapy. Conclusions PSV was commonly detected in patients with mCNV. The presence of neovascular signal of CNV around PSV was prone to recur with a shorter time in mCNV patients.https://doi.org/10.1186/s40662-024-00374-5Perforating scleral vesselChoroidal neovascularizationPathological myopiaAnti-VEGF therapyOptical coherence tomography angiography |
| spellingShingle | Xiangjun She Wangjing Yao Gongyu Huang Zhi Liang Jin Xie Jiwei Tao Sulan Wu Jianbo Mao Yiqi Chen Yun Zhang Lijun Shen Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy Eye and Vision Perforating scleral vessel Choroidal neovascularization Pathological myopia Anti-VEGF therapy Optical coherence tomography angiography |
| title | Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy |
| title_full | Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy |
| title_fullStr | Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy |
| title_full_unstemmed | Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy |
| title_short | Myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti-VEGF therapy |
| title_sort | myopic choroidal neovascularization with neovascular signal around perforating scleral vessel prone to recur after anti vegf therapy |
| topic | Perforating scleral vessel Choroidal neovascularization Pathological myopia Anti-VEGF therapy Optical coherence tomography angiography |
| url | https://doi.org/10.1186/s40662-024-00374-5 |
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