Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application
The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/22/3942 |
| _version_ | 1797508643878338560 |
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| author | Huiru Zhang Zhihao Xu Ying Mao Yingjie Zhang Yan Li Jihong Lao Lu Wang |
| author_facet | Huiru Zhang Zhihao Xu Ying Mao Yingjie Zhang Yan Li Jihong Lao Lu Wang |
| author_sort | Huiru Zhang |
| collection | DOAJ |
| description | The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the ‘MOF-first’ strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN−224 NPs) were pre-synthesized first, and then the composite antibacterial PCN−224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integrated into nanofibers to effectively eliminate bacteria without bacterial resistance and to realize a relatively fast production rate. Upon visible light (630 nm) irradiation for 30 min, the PM−25 NFMs have the best <sup>1</sup>O<sub>2</sub> generation performance, triggering remarkable photodynamic antibacterial effects against both <i>S. aureus</i>, <i>MRSA</i>, and <i>E. coli</i> bacteria with survival rates of 0.13%, 1.91%, and 2.06% respectively. Considering the photodynamic antibacterial performance of the composite nanofibrous membranes functionalized by porphyrinic MOFs, this simple approach may provide a feasible way to use MOF materials and biological materials to construct wound dressing with the versatility to serve as an antibacterial strategy in order to prevent bacterial resistance. |
| first_indexed | 2024-03-10T05:06:48Z |
| format | Article |
| id | doaj.art-359a1cfd6676436b9a4c32cfe677e80a |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T05:06:48Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-359a1cfd6676436b9a4c32cfe677e80a2023-11-23T01:09:11ZengMDPI AGPolymers2073-43602021-11-011322394210.3390/polym13223942Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial ApplicationHuiru Zhang0Zhihao Xu1Ying Mao2Yingjie Zhang3Yan Li4Jihong Lao5Lu Wang6Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, ChinaKey Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, ChinaKey Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, ChinaKey Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, ChinaKey Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, ChinaKey Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, ChinaKey Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, ChinaThe rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the ‘MOF-first’ strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN−224 NPs) were pre-synthesized first, and then the composite antibacterial PCN−224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integrated into nanofibers to effectively eliminate bacteria without bacterial resistance and to realize a relatively fast production rate. Upon visible light (630 nm) irradiation for 30 min, the PM−25 NFMs have the best <sup>1</sup>O<sub>2</sub> generation performance, triggering remarkable photodynamic antibacterial effects against both <i>S. aureus</i>, <i>MRSA</i>, and <i>E. coli</i> bacteria with survival rates of 0.13%, 1.91%, and 2.06% respectively. Considering the photodynamic antibacterial performance of the composite nanofibrous membranes functionalized by porphyrinic MOFs, this simple approach may provide a feasible way to use MOF materials and biological materials to construct wound dressing with the versatility to serve as an antibacterial strategy in order to prevent bacterial resistance.https://www.mdpi.com/2073-4360/13/22/3942metal-organic frameworksphotodynamic therapyantimicrobial nanofiberswound dressing |
| spellingShingle | Huiru Zhang Zhihao Xu Ying Mao Yingjie Zhang Yan Li Jihong Lao Lu Wang Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application Polymers metal-organic frameworks photodynamic therapy antimicrobial nanofibers wound dressing |
| title | Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application |
| title_full | Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application |
| title_fullStr | Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application |
| title_full_unstemmed | Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application |
| title_short | Integrating Porphyrinic Metal-Organic Frameworks in Nanofibrous Carrier for Photodynamic Antimicrobial Application |
| title_sort | integrating porphyrinic metal organic frameworks in nanofibrous carrier for photodynamic antimicrobial application |
| topic | metal-organic frameworks photodynamic therapy antimicrobial nanofibers wound dressing |
| url | https://www.mdpi.com/2073-4360/13/22/3942 |
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