Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update
Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/7/2086 |
| _version_ | 1797562455293952000 |
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| author | Roxane Labrosse François Graham Jean-Christoph Caubet |
| author_facet | Roxane Labrosse François Graham Jean-Christoph Caubet |
| author_sort | Roxane Labrosse |
| collection | DOAJ |
| description | Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affecting the gastrointestinal tract in response to specific dietary antigens. The diagnosis of non-IgE-GI-FA is made clinically, and relies on a constellation of typical symptoms that improve upon removal of the culprit food. When possible, food reintroduction should be attempted, with the documentation of symptoms relapse to establish a conclusive diagnosis. Management includes dietary avoidance, nutritional counselling, and supportive measures in the case of accidental exposure. The prognosis is generally favorable, with the majority of cases resolved before school age. Serial follow-up to establish whether the acquisition of tolerance has occurred is therefore essential in order to avoid unnecessary food restriction and potential consequent nutritional deficiencies. The purpose of this review is to delineate the distinctive clinical features of non-IgE-mediated food allergies presenting with gastrointestinal symptomatology, to summarize our current understanding of the pathogenesis driving these diseases, to discuss recent findings, and to address currents gaps in the knowledge, to guide future management opportunities. |
| first_indexed | 2024-03-10T18:29:26Z |
| format | Article |
| id | doaj.art-359a2b3c509d4295920ad8ecae1475cb |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T18:29:26Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-359a2b3c509d4295920ad8ecae1475cb2023-11-20T06:44:52ZengMDPI AGNutrients2072-66432020-07-01127208610.3390/nu12072086Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An UpdateRoxane Labrosse0François Graham1Jean-Christoph Caubet2Division of Hematology-Oncology, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USADivision of Allergy and Immunology, Department of Pediatrics, CHU Sainte-Justine, University of Montreal, Montreal, QC H3T 1C5, CanadaPediatric Allergy Unit, Department of Woman, Child and Adolescent, University Hospitals of Geneva, 1205 Geneva, SwitzerlandNon-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affecting the gastrointestinal tract in response to specific dietary antigens. The diagnosis of non-IgE-GI-FA is made clinically, and relies on a constellation of typical symptoms that improve upon removal of the culprit food. When possible, food reintroduction should be attempted, with the documentation of symptoms relapse to establish a conclusive diagnosis. Management includes dietary avoidance, nutritional counselling, and supportive measures in the case of accidental exposure. The prognosis is generally favorable, with the majority of cases resolved before school age. Serial follow-up to establish whether the acquisition of tolerance has occurred is therefore essential in order to avoid unnecessary food restriction and potential consequent nutritional deficiencies. The purpose of this review is to delineate the distinctive clinical features of non-IgE-mediated food allergies presenting with gastrointestinal symptomatology, to summarize our current understanding of the pathogenesis driving these diseases, to discuss recent findings, and to address currents gaps in the knowledge, to guide future management opportunities.https://www.mdpi.com/2072-6643/12/7/2086food allergynon-IgE-mediatednutritionpediatricsFPIESFPE |
| spellingShingle | Roxane Labrosse François Graham Jean-Christoph Caubet Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update Nutrients food allergy non-IgE-mediated nutrition pediatrics FPIES FPE |
| title | Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update |
| title_full | Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update |
| title_fullStr | Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update |
| title_full_unstemmed | Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update |
| title_short | Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update |
| title_sort | non ige mediated gastrointestinal food allergies in children an update |
| topic | food allergy non-IgE-mediated nutrition pediatrics FPIES FPE |
| url | https://www.mdpi.com/2072-6643/12/7/2086 |
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