Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic fever
Acute tonsillitis caused by group A b-hemolytic streptococcus (GABHS) remains a challenge both for doctors and the healthcare in general. The article provides evidence of the revival of the highly virulent GABHS infection and the growing incidence of complications (acute rheumatic fever, toxic shock...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2016-12-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/78 |
| _version_ | 1827961974857662464 |
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| author | B. S. Belov |
| author_facet | B. S. Belov |
| author_sort | B. S. Belov |
| collection | DOAJ |
| description | Acute tonsillitis caused by group A b-hemolytic streptococcus (GABHS) remains a challenge both for doctors and the healthcare in general. The article provides evidence of the revival of the highly virulent GABHS infection and the growing incidence of complications (acute rheumatic fever, toxic shock syndrome), and substantiates the need for rational antibiotic therapy of the disease. The drugs of choice for the treatment of acute GABHS tonsillitis are penicillins (amoxicillin, benzathine penicillin, phenoxymethylpenicillin) and 1st-generation cephalosporins (cefadroxil), and, in case of intolerance, b-lactam antibiotics - macrolides. In case of chronic recurrent GABHS tonsillitis, when the risk of colonization of the focal point by microorganisms producing b-lactamase is quite high, inhibitor-protected penicillins (amoxicillin-clavulanate) or 2nd- or 3rd-generation cephalosporins (cefuroxime axetil, cefixime) are administered. Lincosamides (lincomycin, clindamycin) are used in the treatment of acute and chronic GABHS tonsillitis as reserve antibiotics. |
| first_indexed | 2024-04-09T16:35:14Z |
| format | Article |
| id | doaj.art-359a34c404d44e85a967caeb550f7a22 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:35:14Z |
| publishDate | 2016-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-359a34c404d44e85a967caeb550f7a222023-04-23T06:56:54ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902016-12-0104566310.21518/2079-701X-2016-4-56-6378Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic feverB. S. Belov0Nasonova Research Institute of RheumatologyAcute tonsillitis caused by group A b-hemolytic streptococcus (GABHS) remains a challenge both for doctors and the healthcare in general. The article provides evidence of the revival of the highly virulent GABHS infection and the growing incidence of complications (acute rheumatic fever, toxic shock syndrome), and substantiates the need for rational antibiotic therapy of the disease. The drugs of choice for the treatment of acute GABHS tonsillitis are penicillins (amoxicillin, benzathine penicillin, phenoxymethylpenicillin) and 1st-generation cephalosporins (cefadroxil), and, in case of intolerance, b-lactam antibiotics - macrolides. In case of chronic recurrent GABHS tonsillitis, when the risk of colonization of the focal point by microorganisms producing b-lactamase is quite high, inhibitor-protected penicillins (amoxicillin-clavulanate) or 2nd- or 3rd-generation cephalosporins (cefuroxime axetil, cefixime) are administered. Lincosamides (lincomycin, clindamycin) are used in the treatment of acute and chronic GABHS tonsillitis as reserve antibiotics.https://www.med-sovet.pro/jour/article/view/78а-стрептококковый тонзиллитантибиотикотерапияa streptococcal tonsillitisantibiotic treatment |
| spellingShingle | B. S. Belov Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic fever Медицинский совет а-стрептококковый тонзиллит антибиотикотерапия a streptococcal tonsillitis antibiotic treatment |
| title | Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic fever |
| title_full | Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic fever |
| title_fullStr | Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic fever |
| title_full_unstemmed | Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic fever |
| title_short | Diagnosis and rational antibiotic therapy of group A streptococcal infections as the basis for the primary prevention of acute rheumatic fever |
| title_sort | diagnosis and rational antibiotic therapy of group a streptococcal infections as the basis for the primary prevention of acute rheumatic fever |
| topic | а-стрептококковый тонзиллит антибиотикотерапия a streptococcal tonsillitis antibiotic treatment |
| url | https://www.med-sovet.pro/jour/article/view/78 |
| work_keys_str_mv | AT bsbelov diagnosisandrationalantibiotictherapyofgroupastreptococcalinfectionsasthebasisfortheprimarypreventionofacuterheumaticfever |