Synaptic Connectivity in Medium Spiny Neurons of the Nucleus Accumbens: A Sex-Dependent Mechanism Underlying Apathy in the HIV-1 Transgenic Rat

Synaptic Connectivity in Medium Spiny Neurons of the Nucleus Accumbens: A Sex-Dependent Mechanism Underlying Apathy in the HIV-1 Transgenic Rat

Frontal-subcortical circuit dysfunction is commonly associated with apathy, a neuropsychiatric sequelae of human immunodeficiency virus type-1 (HIV-1). Behavioral and neurochemical indices of apathy in the nucleus accumbens (NAc), a key brain region involved in frontal-subcortical circuitry, are inf...

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Bibliographic Details
Main Authors: Kristen A. McLaurin, Anna K. Cook, Hailong Li, Alexis F. League, Charles F. Mactutus, Rosemarie M. Booze
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
HIV-1 transgenic rat
biological sex
apathy
medium spiny neurons
dopamine
diagnostic classification
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00285/full

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