Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.

Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.

Subsets of small-diameter dorsal root ganglia (DRG) neurons detect pruritogenic (itch-causing) and algogenic (pain-causing) stimuli and can be activated or sensitized by chemical mediators. Many of these chemical mediators activate receptors that are coupled to lipid hydrolysis and diacylglycerol (D...

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Bibliographic Details
Main Authors: Victoria Brings Bartsch, Jesse K Niehaus, Bonnie Taylor-Blake, Mark J Zylka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0217819

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