Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats
Despite the acclaimed phytotherapeutic attributes of Stigma maydis in folkloric medicine, there is paucity of information on its toxicity profile on hematological and lipid parameters. The toxicological effect of aqueous extract of corn silk at 100, 200 and 400 mg/kg body weight on hematological ind...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750015000487 |
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| author | Sabiu Saheed Ajani E. Oladipipo Abubakar A. Abdulazeez Sulyman A. Olarewaju Nurain O. Ismaila Irondi A. Emmanuel Quadri D. Fatimah Abubakar Y. Aisha |
| author_facet | Sabiu Saheed Ajani E. Oladipipo Abubakar A. Abdulazeez Sulyman A. Olarewaju Nurain O. Ismaila Irondi A. Emmanuel Quadri D. Fatimah Abubakar Y. Aisha |
| author_sort | Sabiu Saheed |
| collection | DOAJ |
| description | Despite the acclaimed phytotherapeutic attributes of Stigma maydis in folkloric medicine, there is paucity of information on its toxicity profile on hematological and lipid parameters. The toxicological effect of aqueous extract of corn silk at 100, 200 and 400 mg/kg body weight on hematological indices in Wistar rats were evaluated progressively at 24 h after 1, 7, 14, 21 and 28 days. Lipid parameters were also analyzed at the end of the experimental period. We observed that the extract did not exhibit any significant (p > 0.05) effect on red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and mean platelet volume at all the tested doses. The study however showed a significant increase in the serum levels of white blood cell, platelet, lymphocytes, high-density lipoprotein cholesterol; as well as feeding pattern in the animals, while the concentrations of total cholesterol, low-density lipoprotein cholesterol, and artherogenic index value were significantly lowered. These findings are suggestive of non-hematotoxic potential of the extract. Overall, the effect exhibited by corn silk extract in this study proved that, it is unlikely to be hematotoxic and could be a good candidature in the management of coronary heart diseases if consumed at the doses investigated. |
| first_indexed | 2024-12-20T20:38:00Z |
| format | Article |
| id | doaj.art-359e6ee636fb4bacbd81fa8ce6b9abc6 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-20T20:38:00Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-359e6ee636fb4bacbd81fa8ce6b9abc62022-12-21T19:27:10ZengElsevierToxicology Reports2214-75002015-01-012C63864410.1016/j.toxrep.2015.04.001Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar ratsSabiu Saheed0Ajani E. Oladipipo1Abubakar A. Abdulazeez2Sulyman A. Olarewaju3Nurain O. Ismaila4Irondi A. Emmanuel5Quadri D. Fatimah6Abubakar Y. Aisha7Phytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaMedical Laboratory Sciences Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaDespite the acclaimed phytotherapeutic attributes of Stigma maydis in folkloric medicine, there is paucity of information on its toxicity profile on hematological and lipid parameters. The toxicological effect of aqueous extract of corn silk at 100, 200 and 400 mg/kg body weight on hematological indices in Wistar rats were evaluated progressively at 24 h after 1, 7, 14, 21 and 28 days. Lipid parameters were also analyzed at the end of the experimental period. We observed that the extract did not exhibit any significant (p > 0.05) effect on red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and mean platelet volume at all the tested doses. The study however showed a significant increase in the serum levels of white blood cell, platelet, lymphocytes, high-density lipoprotein cholesterol; as well as feeding pattern in the animals, while the concentrations of total cholesterol, low-density lipoprotein cholesterol, and artherogenic index value were significantly lowered. These findings are suggestive of non-hematotoxic potential of the extract. Overall, the effect exhibited by corn silk extract in this study proved that, it is unlikely to be hematotoxic and could be a good candidature in the management of coronary heart diseases if consumed at the doses investigated.http://www.sciencedirect.com/science/article/pii/S2214750015000487Anti-lipidemicHematotoxicLymphocyteMetabolicPhytotherapeuticThrombopoiesis |
| spellingShingle | Sabiu Saheed Ajani E. Oladipipo Abubakar A. Abdulazeez Sulyman A. Olarewaju Nurain O. Ismaila Irondi A. Emmanuel Quadri D. Fatimah Abubakar Y. Aisha Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats Toxicology Reports Anti-lipidemic Hematotoxic Lymphocyte Metabolic Phytotherapeutic Thrombopoiesis |
| title | Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats |
| title_full | Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats |
| title_fullStr | Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats |
| title_full_unstemmed | Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats |
| title_short | Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats |
| title_sort | toxicological evaluations of stigma maydis corn silk aqueous extract on hematological and lipid parameters in wistar rats |
| topic | Anti-lipidemic Hematotoxic Lymphocyte Metabolic Phytotherapeutic Thrombopoiesis |
| url | http://www.sciencedirect.com/science/article/pii/S2214750015000487 |
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