Marine Antitumor Peptide Dolastatin 10: Biological Activity, Structural Modification and Synthetic Chemistry

Marine Antitumor Peptide Dolastatin 10: Biological Activity, Structural Modification and Synthetic Chemistry

Dolastatin 10 (Dol-10), a leading marine pentapeptide isolated from the Indian Ocean mollusk <i>Dolabella auricularia</i>, contains three unique amino acid residues. Dol-10 can effectively induce apoptosis of lung cancer cells and other tumor cells at nanomolar concentration, and it has...

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Bibliographic Details
Main Authors: Gang Gao, Yanbing Wang, Huiming Hua, Dahong Li, Chunlan Tang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Marine Drugs
Subjects:
marine peptide
dolastatin 10
antitumor
lead exploration
Online Access:https://www.mdpi.com/1660-3397/19/7/363

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