Relationship between Cellular Redox Status and Systemic Inflammation Markers
<strong>Background:</strong> the relationship between the reduced and oxidized form of glutathione, GSH/ GSSG, is frequently used as an indicator of the cellular redox state. Under conditions where high levels of oxidizing species are generated, reduced glutathione requirements can be in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Universidad de las Ciencias Médicas de Cienfuegos
2021-07-01
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| Series: | Revista Finlay |
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| Online Access: | http://www.revfinlay.sld.cu/index.php/finlay/article/view/1007 |
| _version_ | 1829459743796625408 |
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| author | Gretel Riverón Forment Tatiana Acosta Sánchez Lilia Caridad Marín Padrón Yaíma Zúñiga Rosales Bárbara Torres Rives Jacqueline Pérez Rodríguez |
| author_facet | Gretel Riverón Forment Tatiana Acosta Sánchez Lilia Caridad Marín Padrón Yaíma Zúñiga Rosales Bárbara Torres Rives Jacqueline Pérez Rodríguez |
| author_sort | Gretel Riverón Forment |
| collection | DOAJ |
| description | <strong>Background:</strong> the relationship between the reduced and oxidized form of glutathione, GSH/ GSSG, is frequently used as an indicator of the cellular redox state. Under conditions where high levels of oxidizing species are generated, reduced glutathione requirements can be increased, and therefore, the cellular redox state can be affected. <br /><strong>Objective:</strong> to determine the relationship between the cellular redox state and systemic markers of inflammation. <br /><strong>Methods:</strong> a descriptive study was carried out in a series of 56 cases referred from the immunogenetics clinic, aged between 1 and 76 years old, of both sexes. Erythrocyte sedimentation rate and serum levels of C-reactive protein were determined as systemic markers of inflammation. The GSH/GSSG ratio was calculated from the intraerythrocyte concentrations of reduced glutathione and its oxidized form, which were determined by an HPLC-UV method. <br /><strong>Results:</strong> the average GSH/GSSG ratio was 7.9 (95 % CI: 6.4-9.4) and age did not influence this proportion. In the cases that had altered values of the inflammation markers, they showed a decrease in the GSH/GSSG ratio. Cellular redox status was negatively correlated with erythrocyte sedimentation values (r=0.41; p=0.017). However, this association does not appear when C-reactive protein levels are analyzed. <br /><strong>Conclusions:</strong> the patients who present alterations in the inflammation markers show changes in the cellular redox state. The combined study of these biomarkers allows a more comprehensive analysis of the health status of patients with inflammatory diseases. |
| first_indexed | 2024-12-12T11:23:58Z |
| format | Article |
| id | doaj.art-35a4c01ab3c54bfeb50b42742bcb12b6 |
| institution | Directory Open Access Journal |
| issn | 2221-2434 |
| language | Spanish |
| last_indexed | 2024-12-12T11:23:58Z |
| publishDate | 2021-07-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj.art-35a4c01ab3c54bfeb50b42742bcb12b62022-12-22T00:25:57ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342021-07-01113316322519Relationship between Cellular Redox Status and Systemic Inflammation MarkersGretel Riverón Forment0Tatiana Acosta Sánchez1Lilia Caridad Marín Padrón2Yaíma Zúñiga Rosales3Bárbara Torres Rives4Jacqueline Pérez Rodríguez5Centro Nacional de Genética Médica. La Habana.Centro Nacional de Genética Médica. La Habana.Centro Nacional de Genética Médica. La Habana.Centro Nacional de Genética Médica. La Habana.Centro Nacional de Genética Médica. La Habana.Centro Nacional de Genética Médica. La Habana.<strong>Background:</strong> the relationship between the reduced and oxidized form of glutathione, GSH/ GSSG, is frequently used as an indicator of the cellular redox state. Under conditions where high levels of oxidizing species are generated, reduced glutathione requirements can be increased, and therefore, the cellular redox state can be affected. <br /><strong>Objective:</strong> to determine the relationship between the cellular redox state and systemic markers of inflammation. <br /><strong>Methods:</strong> a descriptive study was carried out in a series of 56 cases referred from the immunogenetics clinic, aged between 1 and 76 years old, of both sexes. Erythrocyte sedimentation rate and serum levels of C-reactive protein were determined as systemic markers of inflammation. The GSH/GSSG ratio was calculated from the intraerythrocyte concentrations of reduced glutathione and its oxidized form, which were determined by an HPLC-UV method. <br /><strong>Results:</strong> the average GSH/GSSG ratio was 7.9 (95 % CI: 6.4-9.4) and age did not influence this proportion. In the cases that had altered values of the inflammation markers, they showed a decrease in the GSH/GSSG ratio. Cellular redox status was negatively correlated with erythrocyte sedimentation values (r=0.41; p=0.017). However, this association does not appear when C-reactive protein levels are analyzed. <br /><strong>Conclusions:</strong> the patients who present alterations in the inflammation markers show changes in the cellular redox state. The combined study of these biomarkers allows a more comprehensive analysis of the health status of patients with inflammatory diseases.http://www.revfinlay.sld.cu/index.php/finlay/article/view/1007oxidación-reducciónglutationcélulasbiomarcadoresinflamación |
| spellingShingle | Gretel Riverón Forment Tatiana Acosta Sánchez Lilia Caridad Marín Padrón Yaíma Zúñiga Rosales Bárbara Torres Rives Jacqueline Pérez Rodríguez Relationship between Cellular Redox Status and Systemic Inflammation Markers Revista Finlay oxidación-reducción glutation células biomarcadores inflamación |
| title | Relationship between Cellular Redox Status and Systemic Inflammation Markers |
| title_full | Relationship between Cellular Redox Status and Systemic Inflammation Markers |
| title_fullStr | Relationship between Cellular Redox Status and Systemic Inflammation Markers |
| title_full_unstemmed | Relationship between Cellular Redox Status and Systemic Inflammation Markers |
| title_short | Relationship between Cellular Redox Status and Systemic Inflammation Markers |
| title_sort | relationship between cellular redox status and systemic inflammation markers |
| topic | oxidación-reducción glutation células biomarcadores inflamación |
| url | http://www.revfinlay.sld.cu/index.php/finlay/article/view/1007 |
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