The emerging role of long non-coding RNAs in schizophrenia
Schizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding R...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.995956/full |
| _version_ | 1828170865940889600 |
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| author | Guangxian Wu Guangxian Wu Xinzhe Du Xinzhe Du Zexuan Li Zexuan Li Yanhong Du Yanhong Du Jinzhi Lv Jinzhi Lv Xinrong Li Yong Xu Yong Xu Sha Liu Sha Liu |
| author_facet | Guangxian Wu Guangxian Wu Xinzhe Du Xinzhe Du Zexuan Li Zexuan Li Yanhong Du Yanhong Du Jinzhi Lv Jinzhi Lv Xinrong Li Yong Xu Yong Xu Sha Liu Sha Liu |
| author_sort | Guangxian Wu |
| collection | DOAJ |
| description | Schizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of several psychiatric disorders, including SZ, and hold promise as potential biomarkers and therapeutic targets for psychiatric disorders. In this review, we summarize and discuss the role of lncRNAs in the pathogenesis of SZ and their potential value as biomarkers and therapeutic targets. |
| first_indexed | 2024-04-12T03:18:24Z |
| format | Article |
| id | doaj.art-35a6cdf8348f4ca585b48de4abf1d4d0 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T03:18:24Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-35a6cdf8348f4ca585b48de4abf1d4d02022-12-22T03:50:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-09-011310.3389/fpsyt.2022.995956995956The emerging role of long non-coding RNAs in schizophreniaGuangxian Wu0Guangxian Wu1Xinzhe Du2Xinzhe Du3Zexuan Li4Zexuan Li5Yanhong Du6Yanhong Du7Jinzhi Lv8Jinzhi Lv9Xinrong Li10Yong Xu11Yong Xu12Sha Liu13Sha Liu14Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Physiology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Mental Health, Shanxi Medical University, Taiyuan, ChinaShanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, ChinaSchizophrenia (SZ) is a severe psychiatric disorder which is contributed by both genetic and environmental factors. However, at present, its specific pathogenesis is still not very clear, and there is a lack of objective and reliable biomarkers. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of several psychiatric disorders, including SZ, and hold promise as potential biomarkers and therapeutic targets for psychiatric disorders. In this review, we summarize and discuss the role of lncRNAs in the pathogenesis of SZ and their potential value as biomarkers and therapeutic targets.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.995956/fullschizophrenialong non-coding RNAspathophysiologybiomarkertherapy |
| spellingShingle | Guangxian Wu Guangxian Wu Xinzhe Du Xinzhe Du Zexuan Li Zexuan Li Yanhong Du Yanhong Du Jinzhi Lv Jinzhi Lv Xinrong Li Yong Xu Yong Xu Sha Liu Sha Liu The emerging role of long non-coding RNAs in schizophrenia Frontiers in Psychiatry schizophrenia long non-coding RNAs pathophysiology biomarker therapy |
| title | The emerging role of long non-coding RNAs in schizophrenia |
| title_full | The emerging role of long non-coding RNAs in schizophrenia |
| title_fullStr | The emerging role of long non-coding RNAs in schizophrenia |
| title_full_unstemmed | The emerging role of long non-coding RNAs in schizophrenia |
| title_short | The emerging role of long non-coding RNAs in schizophrenia |
| title_sort | emerging role of long non coding rnas in schizophrenia |
| topic | schizophrenia long non-coding RNAs pathophysiology biomarker therapy |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.995956/full |
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