Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy
Vaccinations are a key prevention measure in fighting the COVID-19 pandemic. The BNT162b2 mRNA vaccine (BioNTech/Pfizer), the first to receive authorization, was widely used in the mass vaccination campaign in Italy. Healthcare workers were identified as a priority group for vaccination, but few stu...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/11/1269 |
| _version_ | 1797508287897272320 |
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| author | Alborz Rahmani Guglielmo Dini Andrea Orsi Laura Sticchi Bianca Bruzzone Alfredo Montecucco Luca Pellegrini Alessia Manca Alexander Domnich Angela Battistini Bruno Kusznir Vitturi Sonia Zacconi Nicoletta Debarbieri Giancarlo Icardi Paolo Durando |
| author_facet | Alborz Rahmani Guglielmo Dini Andrea Orsi Laura Sticchi Bianca Bruzzone Alfredo Montecucco Luca Pellegrini Alessia Manca Alexander Domnich Angela Battistini Bruno Kusznir Vitturi Sonia Zacconi Nicoletta Debarbieri Giancarlo Icardi Paolo Durando |
| author_sort | Alborz Rahmani |
| collection | DOAJ |
| description | Vaccinations are a key prevention measure in fighting the COVID-19 pandemic. The BNT162b2 mRNA vaccine (BioNTech/Pfizer), the first to receive authorization, was widely used in the mass vaccination campaign in Italy. Healthcare workers were identified as a priority group for vaccination, but few studies have assessed its reactogenicity among the young working age population. An online survey was conducted to investigate the adverse reactions occurring in the 7 days following the first and second vaccination doses amongst resident doctors of the University of Genoa, employed at the IRCCS Ospedale Policlinico San Martino of Genoa, between 11 January and 16 March 2021. A total of 512 resident physicians were invited to participate in the study (female = 53.2%; mean age = 28.9 years), of whom 296 (female = 53.4%, mean age = 28.9 years) and 275 (female = 55.3%, mean age = 29.1 years) completed the survey after their first and second vaccination doses, respectively. In the 7 days following the first dose, most common adverse reactions were local pain (96.3%), fatigue (42.6%), headache (33.8%), arthromyalgia (28.0%), and 5.1% reported fever, while following the second dose, participants reported local pain (93.5%), fatigue (74.9%), headache (57.5%), arthromyalgia (58.2%), and fever (30.9%), with a higher prevalence among females. Systemic (but not local) reactions increased following the second vaccination, reaching severe intensity in 9.8% of participants and causing three or more events of moderate intensity in 23.7% of participants. Adverse reactions preventing regular daily activities could cause absenteeism among workers. These results can be useful to inform populations of young individuals, set expectations, and improve adherence to vaccination campaigns. |
| first_indexed | 2024-03-10T04:59:58Z |
| format | Article |
| id | doaj.art-35a8cf0c45474c259c9b93047a78a45f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T04:59:58Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-35a8cf0c45474c259c9b93047a78a45f2023-11-23T01:52:04ZengMDPI AGVaccines2076-393X2021-11-01911126910.3390/vaccines9111269Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in ItalyAlborz Rahmani0Guglielmo Dini1Andrea Orsi2Laura Sticchi3Bianca Bruzzone4Alfredo Montecucco5Luca Pellegrini6Alessia Manca7Alexander Domnich8Angela Battistini9Bruno Kusznir Vitturi10Sonia Zacconi11Nicoletta Debarbieri12Giancarlo Icardi13Paolo Durando14Department of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyHygiene Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyOccupational Medicine Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyHygiene Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyHygiene Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyOccupational Medicine Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, 16132 Genoa, ItalyVaccinations are a key prevention measure in fighting the COVID-19 pandemic. The BNT162b2 mRNA vaccine (BioNTech/Pfizer), the first to receive authorization, was widely used in the mass vaccination campaign in Italy. Healthcare workers were identified as a priority group for vaccination, but few studies have assessed its reactogenicity among the young working age population. An online survey was conducted to investigate the adverse reactions occurring in the 7 days following the first and second vaccination doses amongst resident doctors of the University of Genoa, employed at the IRCCS Ospedale Policlinico San Martino of Genoa, between 11 January and 16 March 2021. A total of 512 resident physicians were invited to participate in the study (female = 53.2%; mean age = 28.9 years), of whom 296 (female = 53.4%, mean age = 28.9 years) and 275 (female = 55.3%, mean age = 29.1 years) completed the survey after their first and second vaccination doses, respectively. In the 7 days following the first dose, most common adverse reactions were local pain (96.3%), fatigue (42.6%), headache (33.8%), arthromyalgia (28.0%), and 5.1% reported fever, while following the second dose, participants reported local pain (93.5%), fatigue (74.9%), headache (57.5%), arthromyalgia (58.2%), and fever (30.9%), with a higher prevalence among females. Systemic (but not local) reactions increased following the second vaccination, reaching severe intensity in 9.8% of participants and causing three or more events of moderate intensity in 23.7% of participants. Adverse reactions preventing regular daily activities could cause absenteeism among workers. These results can be useful to inform populations of young individuals, set expectations, and improve adherence to vaccination campaigns.https://www.mdpi.com/2076-393X/9/11/1269COVID-19mRNA vaccinemass vaccination campaignoccupational healthhealthcare workersreactogenicity |
| spellingShingle | Alborz Rahmani Guglielmo Dini Andrea Orsi Laura Sticchi Bianca Bruzzone Alfredo Montecucco Luca Pellegrini Alessia Manca Alexander Domnich Angela Battistini Bruno Kusznir Vitturi Sonia Zacconi Nicoletta Debarbieri Giancarlo Icardi Paolo Durando Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy Vaccines COVID-19 mRNA vaccine mass vaccination campaign occupational health healthcare workers reactogenicity |
| title | Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy |
| title_full | Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy |
| title_fullStr | Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy |
| title_full_unstemmed | Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy |
| title_short | Reactogenicity of BNT162b2 mRNA COVID-19 Vaccine in a Young Working Age Population: A Survey among Medical School Residents, within a Mass Vaccination Campaign, in a Regional Reference Teaching Hospital in Italy |
| title_sort | reactogenicity of bnt162b2 mrna covid 19 vaccine in a young working age population a survey among medical school residents within a mass vaccination campaign in a regional reference teaching hospital in italy |
| topic | COVID-19 mRNA vaccine mass vaccination campaign occupational health healthcare workers reactogenicity |
| url | https://www.mdpi.com/2076-393X/9/11/1269 |
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