Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review
Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/21/3/342 |
| _version_ | 1818067492158832640 |
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| author | Giovana Maria Fioramonti Calixto Jéssica Bernegossi Laura Marise de Freitas Carla Raquel Fontana Marlus Chorilli |
| author_facet | Giovana Maria Fioramonti Calixto Jéssica Bernegossi Laura Marise de Freitas Carla Raquel Fontana Marlus Chorilli |
| author_sort | Giovana Maria Fioramonti Calixto |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer. |
| first_indexed | 2024-12-10T15:24:32Z |
| format | Article |
| id | doaj.art-35a9534fd8f8450eb32228b09ddfcf33 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T15:24:32Z |
| publishDate | 2016-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-35a9534fd8f8450eb32228b09ddfcf332022-12-22T01:43:35ZengMDPI AGMolecules1420-30492016-03-0121334210.3390/molecules21030342molecules21030342Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A ReviewGiovana Maria Fioramonti Calixto0Jéssica Bernegossi1Laura Marise de Freitas2Carla Raquel Fontana3Marlus Chorilli4Faculdade de Ciências Farmacêuticas, UNESP—Univ. Estadual Paulista, Campus Araraquara, Departamento de Fármacos e Medicamentos, Araraquara 14800-903 SP, BrazilFaculdade de Ciências Farmacêuticas, UNESP—Univ. Estadual Paulista, Campus Araraquara, Departamento de Fármacos e Medicamentos, Araraquara 14800-903 SP, BrazilFaculdade de Ciências Farmacêuticas, UNESP—Univ. Estadual Paulista, Campus Araraquara, Departamento de Análises Clínicas, Araraquara 14800-903 SP, BrazilFaculdade de Ciências Farmacêuticas, UNESP—Univ. Estadual Paulista, Campus Araraquara, Departamento de Análises Clínicas, Araraquara 14800-903 SP, BrazilFaculdade de Ciências Farmacêuticas, UNESP—Univ. Estadual Paulista, Campus Araraquara, Departamento de Fármacos e Medicamentos, Araraquara 14800-903 SP, BrazilPhotodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer.http://www.mdpi.com/1420-3049/21/3/342photodynamic therapycancernanotechnologydrug delivery systems |
| spellingShingle | Giovana Maria Fioramonti Calixto Jéssica Bernegossi Laura Marise de Freitas Carla Raquel Fontana Marlus Chorilli Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review Molecules photodynamic therapy cancer nanotechnology drug delivery systems |
| title | Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review |
| title_full | Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review |
| title_fullStr | Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review |
| title_full_unstemmed | Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review |
| title_short | Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review |
| title_sort | nanotechnology based drug delivery systems for photodynamic therapy of cancer a review |
| topic | photodynamic therapy cancer nanotechnology drug delivery systems |
| url | http://www.mdpi.com/1420-3049/21/3/342 |
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