Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province
Background Measles outbreaks often require labor- and resource-intense response. A border-area measles outbreak occurred in Yunnan province that required outbreak response immunization for its containment. We report results of our investigation into the outbreak and the health sector costs of the re...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-05-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1815488 |
| _version_ | 1797677268083933184 |
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| author | Rongrong Zhou Liqun Li Shuyi Yuan Jie Yin Qiongfen Li Licun Guo Mengtian Li Zhixian Zhao Zhizhong Song |
| author_facet | Rongrong Zhou Liqun Li Shuyi Yuan Jie Yin Qiongfen Li Licun Guo Mengtian Li Zhixian Zhao Zhizhong Song |
| author_sort | Rongrong Zhou |
| collection | DOAJ |
| description | Background Measles outbreaks often require labor- and resource-intense response. A border-area measles outbreak occurred in Yunnan province that required outbreak response immunization for its containment. We report results of our investigation into the outbreak and the health sector costs of the response activities, with the goal of providing evidence for policy makers when considering the full value of vaccines and of measles elimination. Methods We conducted case investigations to determine sources of infection and routes of transmission. Costs of outbreak response activities incurred by health sector were determined through retrospective interviews and record reviews of staff. Results In total, 67 measles cases were confirmed, including 4 cases imported from Myanmar. Among the 33 cases aged between 8 months and 14 y old, 22 (66∙7%) had received 2 doses of MCV; 2 (6∙0%) had received 1 dose of MCV; 9 (27∙3%) had not received MCV. The first 4 cases had been infected in Myanmar, and we identified 8 transmission clusters with a total of 62 cases. Transmission among Yunnan province residents occurred in schools, family settings, and at gatherings. The overall cost to control the outbreak was $214,774, for a per-case cost of $3,206. The outbreak response vaccination campaign accounted for 64% of the total outbreak costs. Conclusions Despite high population immunity among Yunnan province children and adolescents, an import-related measles outbreak occurred among individuals who were not vaccinated or had vaccine failure in the across-border area. The economic cost of the outbreak was substantial. Investment in a sensitive measles surveillance system to detect outbreaks in a timely manner, maintaining high population immunity to measles, and reinforcing cross-border collaboration with neighboring countries support achieving and sustaining measles elimination in the border areas of China. |
| first_indexed | 2024-03-11T22:41:37Z |
| format | Article |
| id | doaj.art-35ac28db425f4c12a7b396a6d7619ed5 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:41:37Z |
| publishDate | 2021-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-35ac28db425f4c12a7b396a6d7619ed52023-09-22T08:51:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-05-011751347135210.1080/21645515.2020.18154881815488Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan ProvinceRongrong Zhou0Liqun Li1Shuyi Yuan2Jie Yin3Qiongfen Li4Licun Guo5Mengtian Li6Zhixian Zhao7Zhizhong Song8Yunnan Center for Disease Control and PreventionYunnan Center for Disease Control and PreventionLincang Center for Disease Control and PreventionYunnan Center for Disease Control and PreventionYunnan Center for Disease Control and PreventionLincang Center for Disease Control and PreventionGengma Center for Disease Control and PreventionYunnan Center for Disease Control and PreventionYunnan Center for Disease Control and PreventionBackground Measles outbreaks often require labor- and resource-intense response. A border-area measles outbreak occurred in Yunnan province that required outbreak response immunization for its containment. We report results of our investigation into the outbreak and the health sector costs of the response activities, with the goal of providing evidence for policy makers when considering the full value of vaccines and of measles elimination. Methods We conducted case investigations to determine sources of infection and routes of transmission. Costs of outbreak response activities incurred by health sector were determined through retrospective interviews and record reviews of staff. Results In total, 67 measles cases were confirmed, including 4 cases imported from Myanmar. Among the 33 cases aged between 8 months and 14 y old, 22 (66∙7%) had received 2 doses of MCV; 2 (6∙0%) had received 1 dose of MCV; 9 (27∙3%) had not received MCV. The first 4 cases had been infected in Myanmar, and we identified 8 transmission clusters with a total of 62 cases. Transmission among Yunnan province residents occurred in schools, family settings, and at gatherings. The overall cost to control the outbreak was $214,774, for a per-case cost of $3,206. The outbreak response vaccination campaign accounted for 64% of the total outbreak costs. Conclusions Despite high population immunity among Yunnan province children and adolescents, an import-related measles outbreak occurred among individuals who were not vaccinated or had vaccine failure in the across-border area. The economic cost of the outbreak was substantial. Investment in a sensitive measles surveillance system to detect outbreaks in a timely manner, maintaining high population immunity to measles, and reinforcing cross-border collaboration with neighboring countries support achieving and sustaining measles elimination in the border areas of China.http://dx.doi.org/10.1080/21645515.2020.1815488measlesoutbreakimportationeconomic costs |
| spellingShingle | Rongrong Zhou Liqun Li Shuyi Yuan Jie Yin Qiongfen Li Licun Guo Mengtian Li Zhixian Zhao Zhizhong Song Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province Human Vaccines & Immunotherapeutics measles outbreak importation economic costs |
| title | Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province |
| title_full | Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province |
| title_fullStr | Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province |
| title_full_unstemmed | Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province |
| title_short | Health and economic costs of an import-initiated measles outbreak in an international border area of Yunnan Province |
| title_sort | health and economic costs of an import initiated measles outbreak in an international border area of yunnan province |
| topic | measles outbreak importation economic costs |
| url | http://dx.doi.org/10.1080/21645515.2020.1815488 |
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