Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques
Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A growing interest in the medicinal values of P. macroca...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Saudi Pharmaceutical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423000889 |
| _version_ | 1797813719472799744 |
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| author | Rosliza Ahmad Mohd Khairul Nizam Mazlan Amir Firdaus Abdul Aziz Amirah Mohd Gazzali Mira Syahfriena Amir Rawa Habibah A. Wahab |
| author_facet | Rosliza Ahmad Mohd Khairul Nizam Mazlan Amir Firdaus Abdul Aziz Amirah Mohd Gazzali Mira Syahfriena Amir Rawa Habibah A. Wahab |
| author_sort | Rosliza Ahmad |
| collection | DOAJ |
| description | Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A growing interest in the medicinal values of P. macrocarpa especially in Asia reflects the usage of diverse extraction techniques, particularly modern approaches. In this review article, the extraction methods and solvents relevant to P. macrocarpa were discussed, with the extent of its pharmacological activities. Recent bibliographic databases such as Google Scholar, PubMed, and Elsevier between 2010 and 2022 were assessed. Based on the findings, the pharmacological studies of P. macrocarpa are still pertinent to its traditional uses but primarily emphasise anti-proliferative activity especially colon and breast cancer cells with low toxicity and fruit as the most studied plant part. The utilization of modern separation techniques has predominantly been aimed at extracting mangiferin and phenolic-rich compounds and evaluating their antioxidant capacity. However, the isolation of bioactive compounds remains a challenge, leading to the extensive utilization of the extracts in in vivo studies. This review endeavors to highlight modern extraction methods that could potentially be used as a point of reference in the future for exploring novel bioactive compounds and drug discovery on a multi-scale extraction level. |
| first_indexed | 2024-03-13T07:56:53Z |
| format | Article |
| id | doaj.art-35ac2f81ea5643a2b64b138e6a12fc94 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-13T07:56:53Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-35ac2f81ea5643a2b64b138e6a12fc942023-06-02T04:22:46ZengElsevierSaudi Pharmaceutical Journal1319-01642023-06-01316874888Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniquesRosliza Ahmad0Mohd Khairul Nizam Mazlan1Amir Firdaus Abdul Aziz2Amirah Mohd Gazzali3Mira Syahfriena Amir Rawa4Habibah A. Wahab5Collaborative Laboratory for Herbal Standardization (CHEST), School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11900 Bayan Lepas, Malaysia; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaCollaborative Laboratory for Herbal Standardization (CHEST), School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11900 Bayan Lepas, Malaysia; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaSchool of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, MalaysiaCollaborative Laboratory for Herbal Standardization (CHEST), School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11900 Bayan Lepas, Malaysia; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia; Corresponding authors at: School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.Collaborative Laboratory for Herbal Standardization (CHEST), School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11900 Bayan Lepas, Malaysia; School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia; Faculty of Pharmacy, Padjadjaran University, Sumedang 45363, Indonesia; Corresponding authors at: School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A growing interest in the medicinal values of P. macrocarpa especially in Asia reflects the usage of diverse extraction techniques, particularly modern approaches. In this review article, the extraction methods and solvents relevant to P. macrocarpa were discussed, with the extent of its pharmacological activities. Recent bibliographic databases such as Google Scholar, PubMed, and Elsevier between 2010 and 2022 were assessed. Based on the findings, the pharmacological studies of P. macrocarpa are still pertinent to its traditional uses but primarily emphasise anti-proliferative activity especially colon and breast cancer cells with low toxicity and fruit as the most studied plant part. The utilization of modern separation techniques has predominantly been aimed at extracting mangiferin and phenolic-rich compounds and evaluating their antioxidant capacity. However, the isolation of bioactive compounds remains a challenge, leading to the extensive utilization of the extracts in in vivo studies. This review endeavors to highlight modern extraction methods that could potentially be used as a point of reference in the future for exploring novel bioactive compounds and drug discovery on a multi-scale extraction level.http://www.sciencedirect.com/science/article/pii/S1319016423000889Phaleria macrocarpaMahkota dewaEthnomedicinal plantBiological activityExtraction methodGreen solvent |
| spellingShingle | Rosliza Ahmad Mohd Khairul Nizam Mazlan Amir Firdaus Abdul Aziz Amirah Mohd Gazzali Mira Syahfriena Amir Rawa Habibah A. Wahab Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques Saudi Pharmaceutical Journal Phaleria macrocarpa Mahkota dewa Ethnomedicinal plant Biological activity Extraction method Green solvent |
| title | Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques |
| title_full | Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques |
| title_fullStr | Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques |
| title_full_unstemmed | Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques |
| title_short | Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques |
| title_sort | phaleria macrocarpa scheff boerl an updated review of pharmacological effects toxicity studies and separation techniques |
| topic | Phaleria macrocarpa Mahkota dewa Ethnomedicinal plant Biological activity Extraction method Green solvent |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423000889 |
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