A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in piglets
Antibiotics are widely used as growth promoters (AGPs) in livestock production to improve animal performance and health. However, pig producers today face the prohibition of in-feed antimicrobials and have to find safe and effective alternatives. Lactobacillus species are active microorganisms that...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.1045965/full |
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| author | Cuipeng Zhu Jiacheng Yao Miaonan Zhu Chuyang Zhu Long Yuan Zhaojian Li Demin Cai Shihao Chen Shihao Chen Ping Hu Hao-Yu Liu Hao-Yu Liu |
| author_facet | Cuipeng Zhu Jiacheng Yao Miaonan Zhu Chuyang Zhu Long Yuan Zhaojian Li Demin Cai Shihao Chen Shihao Chen Ping Hu Hao-Yu Liu Hao-Yu Liu |
| author_sort | Cuipeng Zhu |
| collection | DOAJ |
| description | Antibiotics are widely used as growth promoters (AGPs) in livestock production to improve animal performance and health. However, pig producers today face the prohibition of in-feed antimicrobials and have to find safe and effective alternatives. Lactobacillus species are active microorganisms that convey multiple beneficial effects to the host and are one of the most promising AGPs replacements. Here, we aim to comprehensively assess the effects of Lactobacillus spp. supplementation on growth performance and intestinal morphology (villus height [VH], crypt depth [CD], and the V/C ratio) of piglets. Among the 196 identified studies, 20 met the criteria and were included in the meta-analysis. The effects of Lactobacillus-based probiotics supplementation on growth performance and intestinal morphology were analyzed using a random-effects model. And the publication bias was evaluated by funnel plots. Our results revealed that Lactobacillus spp. supplementation significantly improved the growth performance, including average daily feed intake (ADFI), average daily gain (ADG), and the gain-to-feed ratio (G/F) in piglets (P < 0.05). Meanwhile, Lactobacillus spp. remarkably increased VH and the V/C ratio (P < 0.05) in the small intestine, including the duodenum, jejunum, and ileum, which might contribute to an improved digestive capacity of these animals. In conclusion, our findings provide concrete evidence of the growth-promoting effects of Lactobacillus spp. supplementation in piglets and a better understanding of the potential of Lactobacillus-based probiotics as AGPs alternatives in pig production. |
| first_indexed | 2024-04-11T17:44:09Z |
| format | Article |
| id | doaj.art-35ad8ec5fb944e8088f297df9aa2548b |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-11T17:44:09Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-35ad8ec5fb944e8088f297df9aa2548b2022-12-22T04:11:25ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-11-01910.3389/fvets.2022.10459651045965A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in pigletsCuipeng Zhu0Jiacheng Yao1Miaonan Zhu2Chuyang Zhu3Long Yuan4Zhaojian Li5Demin Cai6Shihao Chen7Shihao Chen8Ping Hu9Hao-Yu Liu10Hao-Yu Liu11College of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaInstitute of Epigenetics and Epigenomics, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaCollege of Animal Science and Technology, Yangzhou University, Yangzhou, ChinaInstitute of Epigenetics and Epigenomics, Yangzhou University, Yangzhou, ChinaAntibiotics are widely used as growth promoters (AGPs) in livestock production to improve animal performance and health. However, pig producers today face the prohibition of in-feed antimicrobials and have to find safe and effective alternatives. Lactobacillus species are active microorganisms that convey multiple beneficial effects to the host and are one of the most promising AGPs replacements. Here, we aim to comprehensively assess the effects of Lactobacillus spp. supplementation on growth performance and intestinal morphology (villus height [VH], crypt depth [CD], and the V/C ratio) of piglets. Among the 196 identified studies, 20 met the criteria and were included in the meta-analysis. The effects of Lactobacillus-based probiotics supplementation on growth performance and intestinal morphology were analyzed using a random-effects model. And the publication bias was evaluated by funnel plots. Our results revealed that Lactobacillus spp. supplementation significantly improved the growth performance, including average daily feed intake (ADFI), average daily gain (ADG), and the gain-to-feed ratio (G/F) in piglets (P < 0.05). Meanwhile, Lactobacillus spp. remarkably increased VH and the V/C ratio (P < 0.05) in the small intestine, including the duodenum, jejunum, and ileum, which might contribute to an improved digestive capacity of these animals. In conclusion, our findings provide concrete evidence of the growth-promoting effects of Lactobacillus spp. supplementation in piglets and a better understanding of the potential of Lactobacillus-based probiotics as AGPs alternatives in pig production.https://www.frontiersin.org/articles/10.3389/fvets.2022.1045965/fullLactobacillusprobioticspigletsantibiotic alternativesintestinal morphologygrowth performance |
| spellingShingle | Cuipeng Zhu Jiacheng Yao Miaonan Zhu Chuyang Zhu Long Yuan Zhaojian Li Demin Cai Shihao Chen Shihao Chen Ping Hu Hao-Yu Liu Hao-Yu Liu A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in piglets Frontiers in Veterinary Science Lactobacillus probiotics piglets antibiotic alternatives intestinal morphology growth performance |
| title | A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in piglets |
| title_full | A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in piglets |
| title_fullStr | A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in piglets |
| title_full_unstemmed | A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in piglets |
| title_short | A meta-analysis of Lactobacillus-based probiotics for growth performance and intestinal morphology in piglets |
| title_sort | meta analysis of lactobacillus based probiotics for growth performance and intestinal morphology in piglets |
| topic | Lactobacillus probiotics piglets antibiotic alternatives intestinal morphology growth performance |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.1045965/full |
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