Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around?
Heart failure with preserved ejection fraction (HFpEF) is increasingly recognised to be strongly associated with obesity and abnormalities in fat distribution. Epicardial fat has been associated with abnormal haemodynamics in HFpEF, with potential for direct mechanical effects on the heart causing c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2023-04-01
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| Series: | Cardiac Failure Review |
| Online Access: | https://www.cfrjournal.com/articleindex/cfr.2022.25 |
| _version_ | 1797199971886301184 |
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| author | Mary-Tiffany Oduah Varun Sundaram Yogesh NV Reddy |
| author_facet | Mary-Tiffany Oduah Varun Sundaram Yogesh NV Reddy |
| author_sort | Mary-Tiffany Oduah |
| collection | DOAJ |
| description | Heart failure with preserved ejection fraction (HFpEF) is increasingly recognised to be strongly associated with obesity and abnormalities in fat distribution. Epicardial fat has been associated with abnormal haemodynamics in HFpEF, with potential for direct mechanical effects on the heart causing constriction-like physiology and local myocardial remodelling effects from secretion of inflammatory and profibrotic mediators. However, patients with epicardial fat generally have more systemic and visceral adipose tissue making determination of causality between epicardial fat and HFpEF complex. In this review, we will summarise the evidence for epicardial fat being either directly causal in HFpEF pathogenesis or merely being a correlate of worse systemic inflammatory and generalised adiposity. We will also discuss therapies that directly target epicardial fat and may have potential for treating HFpEF and elucidating the independent role of epicardial fat in its pathogenesis. |
| first_indexed | 2024-03-07T17:39:47Z |
| format | Article |
| id | doaj.art-35ad98fcdcbd4962991ae91304790d0a |
| institution | Directory Open Access Journal |
| issn | 2057-7540 2057-7559 |
| language | English |
| last_indexed | 2024-04-24T07:24:14Z |
| publishDate | 2023-04-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | Cardiac Failure Review |
| spelling | doaj.art-35ad98fcdcbd4962991ae91304790d0a2024-04-20T16:03:18ZengRadcliffe Medical MediaCardiac Failure Review2057-75402057-75592023-04-01910.15420/cfr.2022.25Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around?Mary-Tiffany Oduah0Varun Sundaram1Yogesh NV Reddy2Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USDivision of Cardiovascular Diseases, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USDepartment of Cardiovascular Disease, Mayo Clinic, Rochester, MN, USHeart failure with preserved ejection fraction (HFpEF) is increasingly recognised to be strongly associated with obesity and abnormalities in fat distribution. Epicardial fat has been associated with abnormal haemodynamics in HFpEF, with potential for direct mechanical effects on the heart causing constriction-like physiology and local myocardial remodelling effects from secretion of inflammatory and profibrotic mediators. However, patients with epicardial fat generally have more systemic and visceral adipose tissue making determination of causality between epicardial fat and HFpEF complex. In this review, we will summarise the evidence for epicardial fat being either directly causal in HFpEF pathogenesis or merely being a correlate of worse systemic inflammatory and generalised adiposity. We will also discuss therapies that directly target epicardial fat and may have potential for treating HFpEF and elucidating the independent role of epicardial fat in its pathogenesis.https://www.cfrjournal.com/articleindex/cfr.2022.25 |
| spellingShingle | Mary-Tiffany Oduah Varun Sundaram Yogesh NV Reddy Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around? Cardiac Failure Review |
| title | Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around? |
| title_full | Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around? |
| title_fullStr | Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around? |
| title_full_unstemmed | Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around? |
| title_short | Epicardial Fat in Heart Failure with Preserved Ejection Fraction: Bad Actor or Just Lying Around? |
| title_sort | epicardial fat in heart failure with preserved ejection fraction bad actor or just lying around |
| url | https://www.cfrjournal.com/articleindex/cfr.2022.25 |
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