Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth

Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth

Abstract The development and differentiation of steroidogenic organs are controlled by Ad4BP/SF-1 (adrenal 4 binding protein/steroidogenic factor 1). Besides, lysosomal activity is required for steroidogenesis and also enables adrenocortical cell to survive during stress. However, the role of lysoso...

Full description

Bibliographic Details
Main Authors:	Jhih-Siang Syu, Takashi Baba, Jyun-Yuan Huang, Hidesato Ogawa, Chi-Han Hsieh, Jin-Xian Hu, Ting-Yu Chen, Tzu-Chien Lin, Megumi Tsuchiya, Ken-Ichirou Morohashi, Bu-Miin Huang, Fu-l. Lu, Chia-Yih Wang
Format:	Article
Language:	English
Published:	Nature Portfolio 2017-03-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-00393-4

Similar Items

Differential Response of Transcription Factors to Activated Kinases in Steroidogenic and Non-Steroidogenic Cells
by: Kenley Joule Pierre, et al.
Published: (2022-10-01)

Steroidogenic effects of Taraxacum officinale extract on the levels of steroidogenic enzymes in mouse Leydig cells
by: Hyun Joo Chung, et al.
Published: (2018-11-01)

Expression of inhibin-alpha is regulated synergistically by Wilms' tumor gene 1 (Wt1) and steroidogenic factor-1 (Sf1) in sertoli cells.
by: Shao-Yang Ji, et al.
Published: (2013-01-01)

Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells.
by: Kanako Miyabayashi, et al.
Published: (2013-01-01)

Steroidogenic electron-transfer factors and their diseases
by: Walter L. Miller
Published: (2021-09-01)

Proliferation of luteal steroidogenic cells in cattle.
by: Shin Yoshioka, et al.
Published: (2013-01-01)

Steroidogenic factor-1 (SF-1) gene mutation as a frequent cause of primary amenorrhea in 46,XY female adolescents with low testosterone concentration
by: Servant Nadège, et al.
Published: (2010-03-01)

Glycolysis Dependency as a Hallmark of <i>SF3B1</i>-Mutated Cells
by: Raquel Vivet-Noguer, et al.
Published: (2022-04-01)

HGF/SF Activates Glycolysis and Oxidative Phosphorylation in DA3 Murine Mammary Cancer Cells
by: Ofer Kaplan, et al.
Published: (2000-07-01)

Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis
by: Anna Zubrzycka, et al.
Published: (2020-05-01)

Androstenedione changes steroidogenic activity of SGBS cells
by: Jana Ernst, et al.
Published: (2020-07-01)

Expression of steroidogenic enzymes in porcine polycystic ovaries.
by: Mariusz Majewski, et al.
Published: (2009-12-01)

Functional Analysis of Steroidogenic Factor 1 (sf-1) and 17α-Hydroxylase/Lyase (cyp17α) Promoters in Yellow Catfish <i>Pelteobagrus fulvidraco</i>
by: Wu-Hong Lv, et al.
Published: (2020-12-01)

Transactivation of miR-202-5p by Steroidogenic Factor 1 (SF1) Induces Apoptosis in Goat Granulosa Cells by Targeting TGFβR2
by: Qiang Ding, et al.
Published: (2020-02-01)

Cytosolic NUAK1 Enhances ATP Production by Maintaining Proper Glycolysis and Mitochondrial Function in Cancer Cells
by: Emilia Escalona, et al.
Published: (2020-07-01)

Coordination of Multiple Cellular Processes by
by: Ken-ichirou Morohashi, et al.
Published: (2020-12-01)

Deciphering the origins and fates of steroidogenic lineages in the mouse testis
by: Herta Ademi, et al.
Published: (2022-06-01)

Impact of ACTH signaling on transcriptional regulation of steroidogenic genes
by: Carmen eRuggiero, et al.
Published: (2016-03-01)

LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
by: Yun Wang, et al.
Published: (2019-12-01)

Incomplete Pattern of Steroidogenic Protein Expression in Functioning Adrenocortical Carcinomas
by: Sofia S. Pereira, et al.
Published: (2020-07-01)

Effects of nandrolone decanoate on expression of steroidogenic enzymes in the rat testis
by: TaeSun Min, et al.
Published: (2018-05-01)

Expressions of genes encoding steroidogenic enzymes and their role in prostate carcinogenesis
by: Bartosz A. Frycz, et al.
Published: (2014-03-01)

Testicular inducing steroidogenic cells trigger sex change in groupers
by: Ryosuke Murata, et al.
Published: (2021-05-01)

Exportin 4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9.
by: Megumi Tsuchiya, et al.
Published: (2011-01-01)

TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction
by: Cheoljun Choi, et al.
Published: (2024-03-01)

Glucose‐mediated mitochondrial reprogramming by cholesterol export at TM4SF5‐enriched mitochondria‐lysosome contact sites
by: Ji Eon Kim, et al.
Published: (2024-01-01)

Functional assessment of lysosomal Rab7 and RILP with RNA interference and overexpression in Spodoptera frugiperda Sf9 cell lines
by: Gaofeng Cui, et al.
Published: (2023-12-01)

Mitochondria and Lysosomes Participate in Vip3Aa-Induced <i>Spodoptera frugiperda</i> Sf9 Cell Apoptosis
by: Xiaoyue Hou, et al.
Published: (2020-02-01)

The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting
by: Gabriele Floris, et al.
Published: (2022-04-01)

Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450
by: Katyayani Sharma, et al.
Published: (2024-02-01)

Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells
by: Rona Karahoda, et al.
Published: (2021-02-01)

Steroidogenic Enzyme and Steroid Receptor Expression in the Equine Accessory Sex Glands
by: Robyn E. Ellerbrock, et al.
Published: (2021-08-01)

Steroidogenic control of liver metabolism through a nuclear receptor-network
by: Alexandra Milona, et al.
Published: (2019-12-01)

Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
by: Megan McGrath, et al.
Published: (2019-08-01)

Modulation of gonadotrophin induced steroidogenic enzymes in granulosa cells by d-chiroinositol
by: Sandro Sacchi, et al.
Published: (2018-12-01)

ACTH Action on Steroidogenic Acute Regulatory Protein (StAR) Biology
by: Barbara J Clark
Published: (2016-12-01)

Fluorescent BODIPY dyes as ligands for major steroidogenic proteins: in silico evaluation
by: Matvey S. Horetski, et al.
Published: (2018-04-01)

Aerobic glycolysis enhances HBx-initiated hepatocellular carcinogenesis via NF-κBp65/HK2 signalling
by: Lingjun Chen, et al.
Published: (2022-11-01)

A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads
by: Yifu Wang, et al.
Published: (2022-11-01)

Ablation state assessment of SF6 circuit breaker contacts based on BP neural network and mean impact value
by: Qiang Wu, et al.
Published: (2022-08-01)