Inflammation hypothesis of depression by IL-17
Despite high prevalence of depressive disorders, their etiopathogenesis has not been fully understood. Only around 2/3 of patients suffering from depression respond to the standard antidepressant treatment. Hence, further studies searching for possible pathological mechanisms and potential contribut...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Journal of Affective Disorders Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915323000628 |
| _version_ | 1797854452913274880 |
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| author | Katarzyna Bliźniewska-Kowalska |
| author_facet | Katarzyna Bliźniewska-Kowalska |
| author_sort | Katarzyna Bliźniewska-Kowalska |
| collection | DOAJ |
| description | Despite high prevalence of depressive disorders, their etiopathogenesis has not been fully understood. Only around 2/3 of patients suffering from depression respond to the standard antidepressant treatment. Hence, further studies searching for possible pathological mechanisms and potential contributory factors to treatment-resistance are necessary in order to find new, effective and safe antidepressant therapies. Depression frequently coexists with other autoimmune disorders. Some studies reveal hat biological agents targeting interleukin 17 (IL-17), when used in patients with autoimmune diseases may have clinical efficacy in the treatment of depressive disorders. This presentation will address the inflammation hypothesis of depression, focusing on interleukin 17 (IL-17), among other proinflammatory cytokines, that might play an important role in the development of depressive disorders. |
| first_indexed | 2024-04-09T20:07:23Z |
| format | Article |
| id | doaj.art-35b22f1919bd4c2ca089268bb0b78b4e |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-04-09T20:07:23Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-35b22f1919bd4c2ca089268bb0b78b4e2023-04-01T08:51:33ZengElsevierJournal of Affective Disorders Reports2666-91532023-04-0112100523Inflammation hypothesis of depression by IL-17Katarzyna Bliźniewska-Kowalska0Department of Adult Psychiatry, Medical University of Lodz, Aleksandrowska 159, Łódź, PolandDespite high prevalence of depressive disorders, their etiopathogenesis has not been fully understood. Only around 2/3 of patients suffering from depression respond to the standard antidepressant treatment. Hence, further studies searching for possible pathological mechanisms and potential contributory factors to treatment-resistance are necessary in order to find new, effective and safe antidepressant therapies. Depression frequently coexists with other autoimmune disorders. Some studies reveal hat biological agents targeting interleukin 17 (IL-17), when used in patients with autoimmune diseases may have clinical efficacy in the treatment of depressive disorders. This presentation will address the inflammation hypothesis of depression, focusing on interleukin 17 (IL-17), among other proinflammatory cytokines, that might play an important role in the development of depressive disorders.http://www.sciencedirect.com/science/article/pii/S2666915323000628 |
| spellingShingle | Katarzyna Bliźniewska-Kowalska Inflammation hypothesis of depression by IL-17 Journal of Affective Disorders Reports |
| title | Inflammation hypothesis of depression by IL-17 |
| title_full | Inflammation hypothesis of depression by IL-17 |
| title_fullStr | Inflammation hypothesis of depression by IL-17 |
| title_full_unstemmed | Inflammation hypothesis of depression by IL-17 |
| title_short | Inflammation hypothesis of depression by IL-17 |
| title_sort | inflammation hypothesis of depression by il 17 |
| url | http://www.sciencedirect.com/science/article/pii/S2666915323000628 |
| work_keys_str_mv | AT katarzynablizniewskakowalska inflammationhypothesisofdepressionbyil17 |