Identifying Novel Copy Number Variants in Azoospermia Factor Regions and Evaluating Their Effects on Spermatogenic Impairment

Identifying Novel Copy Number Variants in Azoospermia Factor Regions and Evaluating Their Effects on Spermatogenic Impairment

Microdeletions in Y-chromosomal azoospermia factor (AZF) regions have been regarded as the risk factor of spermatogenic failure (SF). However, AZF-linked duplications or complex copy number variants (CNVs) (deletion + duplication) were rarely studied. In this study, we performed multiplex ligation-d...

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Bibliographic Details
Main Authors: Ran Zhou, Jian Cheng, Dingyuan Ma, Jianxin Tan, Yuguo Wang, Ping Hu, Zhengfeng Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
male infertility
Y chromosome
azoospermia factor regions
spermatogenic failure
copy number variants
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00427/full

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