Refractive and Vision Status in Down Syndrome: A Comparative Study
Objectives:To determine the prevalence of refractive errors and visual impairment in Down syndrome (DS) patients compared to normal controls.Materials and Methods:Cycloplegic refraction was tested in 213 DS patients and 184 normal age- and gender-matched controls using autorefraction followed by ret...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2021-08-01
|
| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/refractive-and-vision-status-in-down-syndrome-a-co/48745
|
| _version_ | 1828027519631097856 |
|---|---|
| author | Hassan Hashemi Shiva Mehravaran Soheila Asgari Farzaneh Dehghanian Nasrabadi |
| author_facet | Hassan Hashemi Shiva Mehravaran Soheila Asgari Farzaneh Dehghanian Nasrabadi |
| author_sort | Hassan Hashemi |
| collection | DOAJ |
| description | Objectives:To determine the prevalence of refractive errors and visual impairment in Down syndrome (DS) patients compared to normal controls.Materials and Methods:Cycloplegic refraction was tested in 213 DS patients and 184 normal age- and gender-matched controls using autorefraction followed by retinoscopy. Data from the worse eye of each case were used in the analyses.Results:In the DS and control groups, respectively, mean age was 17.2±4.8 and 17.2±4.4 years (p=0.993) and 53.0% and 49.5% were male (p=0.473). In the DS and control groups, respectively, mean spherical equivalent (SE) was -5.13±4.47 and -4.15±3.04 diopters (D) in myopics (p=0.050) and 2.47±1.64 and 2.36±2.04 D in hyperopics (p=0.482), mean cylinder error was -2.17±1.39 and -2.05±1.57 D (p=0.451), mean J0 was -0.03±0.89 and 0.12±0.76 D (p=0.086), and mean J45 was 0.11±1.02 and -0.13±1.03 D (p=0.024). The prevalence of oblique astigmatism was higher in the DS group (20.4% vs. 6.1%) while against-the-rule astigmatism was more prevalent in the control group (84.0% vs. 71.6%) (p<0.001). The prevalence of anisometropia was not significantly different between the groups (19.4% vs. 13.8%). Visual impairment was detected in 11.7% of the DS and 0.5% of the control group (p<0.001). The prevalence of amblyopia was 36.3% and 3.8% in the DS and control groups, respectively (p<0.001). Based on the multiple model, only absolute SE inversely correlated with age and differed between males and females (all p<0.05).Conclusion:In DS patients, the prevalence rates of refractive errors, amblyopia, and visual impairment are higher than those in non-DS individuals, and emmetropization appears to be either defective or slow. Cylinder error is stable in this age range, but the rotation of astigmatism axis is different from normal samples. |
| first_indexed | 2024-04-10T13:37:36Z |
| format | Article |
| id | doaj.art-35b466a5d3d0486e965fd3984d40d895 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T13:37:36Z |
| publishDate | 2021-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-35b466a5d3d0486e965fd3984d40d8952023-02-15T16:11:19ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612021-08-0151419920510.4274/tjo.galenos.2020.5295913049054Refractive and Vision Status in Down Syndrome: A Comparative StudyHassan Hashemi0Shiva Mehravaran1Soheila Asgari2Farzaneh Dehghanian Nasrabadi3 Noor Göz Hastanesi, Noor Oftalmoloji Araştırma Merkezi, Tahran, İran İran Tıp Bilimleri Üniversitesi Rehabilitasyon Fakültesi, Optometri Anabilim Dalı, Tahran, İran Morgan State Üniversitesi, Ascend Biomedikal Araştırma Merkezi, Baltimore, MD, ABD Noor Göz Hastanesi, Noor Oftalmolojik Epidemiyoloji Araştırma Merkezi, Tahran, İran Objectives:To determine the prevalence of refractive errors and visual impairment in Down syndrome (DS) patients compared to normal controls.Materials and Methods:Cycloplegic refraction was tested in 213 DS patients and 184 normal age- and gender-matched controls using autorefraction followed by retinoscopy. Data from the worse eye of each case were used in the analyses.Results:In the DS and control groups, respectively, mean age was 17.2±4.8 and 17.2±4.4 years (p=0.993) and 53.0% and 49.5% were male (p=0.473). In the DS and control groups, respectively, mean spherical equivalent (SE) was -5.13±4.47 and -4.15±3.04 diopters (D) in myopics (p=0.050) and 2.47±1.64 and 2.36±2.04 D in hyperopics (p=0.482), mean cylinder error was -2.17±1.39 and -2.05±1.57 D (p=0.451), mean J0 was -0.03±0.89 and 0.12±0.76 D (p=0.086), and mean J45 was 0.11±1.02 and -0.13±1.03 D (p=0.024). The prevalence of oblique astigmatism was higher in the DS group (20.4% vs. 6.1%) while against-the-rule astigmatism was more prevalent in the control group (84.0% vs. 71.6%) (p<0.001). The prevalence of anisometropia was not significantly different between the groups (19.4% vs. 13.8%). Visual impairment was detected in 11.7% of the DS and 0.5% of the control group (p<0.001). The prevalence of amblyopia was 36.3% and 3.8% in the DS and control groups, respectively (p<0.001). Based on the multiple model, only absolute SE inversely correlated with age and differed between males and females (all p<0.05).Conclusion:In DS patients, the prevalence rates of refractive errors, amblyopia, and visual impairment are higher than those in non-DS individuals, and emmetropization appears to be either defective or slow. Cylinder error is stable in this age range, but the rotation of astigmatism axis is different from normal samples. http://www.oftalmoloji.org/archives/archive-detail/article-preview/refractive-and-vision-status-in-down-syndrome-a-co/48745 refractive errorsvisual impairmentamblyopiaemmetropizationdown syndromecomparative study |
| spellingShingle | Hassan Hashemi Shiva Mehravaran Soheila Asgari Farzaneh Dehghanian Nasrabadi Refractive and Vision Status in Down Syndrome: A Comparative Study Türk Oftalmoloji Dergisi refractive errors visual impairment amblyopia emmetropization down syndrome comparative study |
| title | Refractive and Vision Status in Down Syndrome: A Comparative Study |
| title_full | Refractive and Vision Status in Down Syndrome: A Comparative Study |
| title_fullStr | Refractive and Vision Status in Down Syndrome: A Comparative Study |
| title_full_unstemmed | Refractive and Vision Status in Down Syndrome: A Comparative Study |
| title_short | Refractive and Vision Status in Down Syndrome: A Comparative Study |
| title_sort | refractive and vision status in down syndrome a comparative study |
| topic | refractive errors visual impairment amblyopia emmetropization down syndrome comparative study |
| url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/refractive-and-vision-status-in-down-syndrome-a-co/48745
|
| work_keys_str_mv | AT hassanhashemi refractiveandvisionstatusindownsyndromeacomparativestudy AT shivamehravaran refractiveandvisionstatusindownsyndromeacomparativestudy AT soheilaasgari refractiveandvisionstatusindownsyndromeacomparativestudy AT farzanehdehghaniannasrabadi refractiveandvisionstatusindownsyndromeacomparativestudy |