Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature
In HIV infected patients an increased incidence of cardiac events has been reported since the introduction of highly active antiretroviral therapy (HAART). Antiretroviral drugs’ regimens are, in fact, associated with several metabolic side effects, such as dyslipidemia, impaired glucose metabolism a...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2015-12-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/174 |
| _version_ | 1828346230065856512 |
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| author | Laura Casaretti Stefania Paolillo Roberto Formisano Ada Bologna Giacomo Mattiello Sirio Conte Laura Petraglia Francesco Lo Iudice Irma Fabiani Anna Paola Cirillo Alice Vitagliano Francesco Gambardella Giuseppe Luca della Ratta Pasquale Perrone Filardi |
| author_facet | Laura Casaretti Stefania Paolillo Roberto Formisano Ada Bologna Giacomo Mattiello Sirio Conte Laura Petraglia Francesco Lo Iudice Irma Fabiani Anna Paola Cirillo Alice Vitagliano Francesco Gambardella Giuseppe Luca della Ratta Pasquale Perrone Filardi |
| author_sort | Laura Casaretti |
| collection | DOAJ |
| description | In HIV infected patients an increased incidence of cardiac events has been reported since the introduction of highly active antiretroviral therapy (HAART). Antiretroviral drugs’ regimens are, in fact, associated with several metabolic side effects, such as dyslipidemia, impaired glucose metabolism and abnormal body fat distribution, that increase cardiovascular risk of HIV subjects. In addition, HIV infection itself, the chronic inflammatory status and the frequent presence in this population of traditional risk factors contribute to an higher incidence of cardio and cerebrovascular events. In last years several studies showed the occurrence of carotid vascular impairment in patients treated with protease inhibitors (PI). Similarly the DAD Study reported an increase of 26% of the risk of myocardial infarction in patients on HAART and that this risk was independently associated with longer exposure to PI, after multivariate adjustments. A correct evaluation of the metabolic status before starting HAART and an adequate control of drugs-related metabolic abnormalities may reduce the incidence of cardiac events and still improve HIV patients prognosis. This review will focus on the metabolic effects of antiretroviral drugs and on the contribution of combination antiretroviral therapy on cardiovascular risk. |
| first_indexed | 2024-04-14T00:23:33Z |
| format | Article |
| id | doaj.art-35b48a6dbe2b41ac8c28108e7ad03862 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-04-14T00:23:33Z |
| publishDate | 2015-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-35b48a6dbe2b41ac8c28108e7ad038622022-12-22T02:22:50ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642015-12-0176410.4081/monaldi.2011.174Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literatureLaura Casaretti0Stefania Paolillo1Roberto Formisano2Ada Bologna3Giacomo Mattiello4Sirio Conte5Laura Petraglia6Francesco Lo Iudice7Irma Fabiani8Anna Paola Cirillo9Alice Vitagliano10Francesco Gambardella11Giuseppe Luca della Ratta12Pasquale Perrone Filardi13Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliDipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università Federico II, NapoliIn HIV infected patients an increased incidence of cardiac events has been reported since the introduction of highly active antiretroviral therapy (HAART). Antiretroviral drugs’ regimens are, in fact, associated with several metabolic side effects, such as dyslipidemia, impaired glucose metabolism and abnormal body fat distribution, that increase cardiovascular risk of HIV subjects. In addition, HIV infection itself, the chronic inflammatory status and the frequent presence in this population of traditional risk factors contribute to an higher incidence of cardio and cerebrovascular events. In last years several studies showed the occurrence of carotid vascular impairment in patients treated with protease inhibitors (PI). Similarly the DAD Study reported an increase of 26% of the risk of myocardial infarction in patients on HAART and that this risk was independently associated with longer exposure to PI, after multivariate adjustments. A correct evaluation of the metabolic status before starting HAART and an adequate control of drugs-related metabolic abnormalities may reduce the incidence of cardiac events and still improve HIV patients prognosis. This review will focus on the metabolic effects of antiretroviral drugs and on the contribution of combination antiretroviral therapy on cardiovascular risk.https://www.monaldi-archives.org/index.php/macd/article/view/174HIVantiretroviral drugscardiovascular riskmetabolic syndromemyocardial infarction. |
| spellingShingle | Laura Casaretti Stefania Paolillo Roberto Formisano Ada Bologna Giacomo Mattiello Sirio Conte Laura Petraglia Francesco Lo Iudice Irma Fabiani Anna Paola Cirillo Alice Vitagliano Francesco Gambardella Giuseppe Luca della Ratta Pasquale Perrone Filardi Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature Monaldi Archives for Chest Disease HIV antiretroviral drugs cardiovascular risk metabolic syndrome myocardial infarction. |
| title | Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature |
| title_full | Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature |
| title_fullStr | Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature |
| title_full_unstemmed | Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature |
| title_short | Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature |
| title_sort | metabolic and cardiovascular effects of combined antiretroviral therapy in patients with hiv infection systematic review of literature |
| topic | HIV antiretroviral drugs cardiovascular risk metabolic syndrome myocardial infarction. |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/174 |
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