Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL)
Low-density lipoprotein (LDL) modification such as oxidation and glycation has been known to play a significant role in the initiation and progression of atherosclerosis. The inhibitors on LDL modification have been emerged as a new strategy to be a supplement for prevention of atherosclerosis. In a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619303081 |
| _version_ | 1818938210022064128 |
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| author | Jae-Yong Kim Jung Woo Lee Jin Soo Lee Dae Sik Jang Sang Hee Shim |
| author_facet | Jae-Yong Kim Jung Woo Lee Jin Soo Lee Dae Sik Jang Sang Hee Shim |
| author_sort | Jae-Yong Kim |
| collection | DOAJ |
| description | Low-density lipoprotein (LDL) modification such as oxidation and glycation has been known to play a significant role in the initiation and progression of atherosclerosis. The inhibitors on LDL modification have been emerged as a new strategy to be a supplement for prevention of atherosclerosis. In an effort to discover inhibitors on LDL modification from natural products, phytochemical investigation on Cynanchum wilfordii roots were performed, leading to isolation of acetophenones (1–6) including a new one (1) and nine pregnane-type steroids (7–15). The structure of the compound 1 was determined by analysis of 1D and 2D NMR spectral data analysis. All the isolated compounds were evaluated for their inhibitory activities against LDL modification. Among them, compounds 2 and 5 strongly inhibited LDL oxidation and glycation. These results suggest that compounds 2 and 5 from C. wilfordii may provide potential protective effects against atherosclerosis via inhibition of LDL oxidation and glycation. |
| first_indexed | 2024-12-20T06:04:14Z |
| format | Article |
| id | doaj.art-35b5ff34e730464dbf1c1e3d8223051e |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T06:04:14Z |
| publishDate | 2019-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-35b5ff34e730464dbf1c1e3d8223051e2022-12-21T19:50:51ZengElsevierJournal of Functional Foods1756-46462019-08-0159281290Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL)Jae-Yong Kim0Jung Woo Lee1Jin Soo Lee2Dae Sik Jang3Sang Hee Shim4College of Pharmacy, Duksung Women’s University, 144 Gil-33, Samyang-ro, Dobong-gu, Seoul 01369, Republic of KoreaCollege of Pharmacy, Duksung Women’s University, 144 Gil-33, Samyang-ro, Dobong-gu, Seoul 01369, Republic of KoreaDepartment of Life & Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of KoreaDepartment of Life & Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea; Corresponding authors.College of Pharmacy, Duksung Women’s University, 144 Gil-33, Samyang-ro, Dobong-gu, Seoul 01369, Republic of Korea; Corresponding authors.Low-density lipoprotein (LDL) modification such as oxidation and glycation has been known to play a significant role in the initiation and progression of atherosclerosis. The inhibitors on LDL modification have been emerged as a new strategy to be a supplement for prevention of atherosclerosis. In an effort to discover inhibitors on LDL modification from natural products, phytochemical investigation on Cynanchum wilfordii roots were performed, leading to isolation of acetophenones (1–6) including a new one (1) and nine pregnane-type steroids (7–15). The structure of the compound 1 was determined by analysis of 1D and 2D NMR spectral data analysis. All the isolated compounds were evaluated for their inhibitory activities against LDL modification. Among them, compounds 2 and 5 strongly inhibited LDL oxidation and glycation. These results suggest that compounds 2 and 5 from C. wilfordii may provide potential protective effects against atherosclerosis via inhibition of LDL oxidation and glycation.http://www.sciencedirect.com/science/article/pii/S1756464619303081Cynanchum wilfordiiPhenolic compoundPregnane-type steroidsLow-density lipoprotein (LDL)OxidationGlycation |
| spellingShingle | Jae-Yong Kim Jung Woo Lee Jin Soo Lee Dae Sik Jang Sang Hee Shim Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL) Journal of Functional Foods Cynanchum wilfordii Phenolic compound Pregnane-type steroids Low-density lipoprotein (LDL) Oxidation Glycation |
| title | Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL) |
| title_full | Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL) |
| title_fullStr | Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL) |
| title_full_unstemmed | Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL) |
| title_short | Inhibitory effects of compounds isolated from roots of Cynanchum wilfordii on oxidation and glycation of human low-density lipoprotein (LDL) |
| title_sort | inhibitory effects of compounds isolated from roots of cynanchum wilfordii on oxidation and glycation of human low density lipoprotein ldl |
| topic | Cynanchum wilfordii Phenolic compound Pregnane-type steroids Low-density lipoprotein (LDL) Oxidation Glycation |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619303081 |
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