Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals

The systematic mutation of histone 3 (H3) genes in model organisms has proven to be a valuable tool to distinguish the functional role of histone residues. No system exists in mammalian cells to directly manipulate canonical histone H3 due to a large number of clustered and multi-loci histone genes....

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Bibliographic Details
Main Authors: Matteo Trovato, Vibha Patil, Maja Gehre, Kyung Min Noh
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
H3.3
H3
histone variants
histones
post-translational modifications
PTMs
Online Access:https://www.mdpi.com/2073-4409/9/12/2716

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