Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular Carcinoma
The aim of this study was to assess the long-term results of liver transplantation (LT) in pediatric patients with unresectable hepatoblastoma (HB) or hepatocellular carcinoma (HCC) with special reference to the risk of tumor recurrence. We retrospectively analyzed data from 46 HB and 26 HCC patient...
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MDPI AG
2024-02-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/11/2/193 |
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| author | Marek Stefanowicz Piotr Kaliciński Hor Ismail Adam Kowalski Dorota Broniszczak Marek Szymczak Katarzyna Pankowska-Woźniak Anna Roszkiewicz Ewa Święszkowska Diana Kamińska Sylwia Szymańska Grzegorz Kowalewski |
| author_facet | Marek Stefanowicz Piotr Kaliciński Hor Ismail Adam Kowalski Dorota Broniszczak Marek Szymczak Katarzyna Pankowska-Woźniak Anna Roszkiewicz Ewa Święszkowska Diana Kamińska Sylwia Szymańska Grzegorz Kowalewski |
| author_sort | Marek Stefanowicz |
| collection | DOAJ |
| description | The aim of this study was to assess the long-term results of liver transplantation (LT) in pediatric patients with unresectable hepatoblastoma (HB) or hepatocellular carcinoma (HCC) with special reference to the risk of tumor recurrence. We retrospectively analyzed data from 46 HB and 26 HCC patients who underwent LT between 1990 and 2022. In HCC patients, we compared outcomes depending on donor type. We evaluated the impact of a number of risk factors on recurrence-free survival after LT. Estimated patient survival after 5, 10, and 15 years was 82%, 73%, and 73% in the HB group and 79%, 75%, and 75% in the HCC group, respectively (<i>p</i> = 0.76). In the HCC group, living donor LT (LDLT) and deceased donor LT (DDLT) provided similar patient survival (<i>p</i> = 0.09). Estimated recurrence-free survival in patients who had three or fewer risk factors was significantly better than in patients with more than three risk factors (<i>p</i> = 0.0001). Adequate patient selection is necessary when considering LT for primary liver tumors in children. The presence of more than three risk factors is associated with a very high risk of recurrence and indicates poor prognosis, whereas extrahepatic disease may be considered a contraindication for transplantation. |
| first_indexed | 2024-03-07T22:37:28Z |
| format | Article |
| id | doaj.art-35b6d0cfd1d349f1a35d8572b370cf0a |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-07T22:37:28Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-35b6d0cfd1d349f1a35d8572b370cf0a2024-02-23T15:12:21ZengMDPI AGChildren2227-90672024-02-0111219310.3390/children11020193Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular CarcinomaMarek Stefanowicz0Piotr Kaliciński1Hor Ismail2Adam Kowalski3Dorota Broniszczak4Marek Szymczak5Katarzyna Pankowska-Woźniak6Anna Roszkiewicz7Ewa Święszkowska8Diana Kamińska9Sylwia Szymańska10Grzegorz Kowalewski11Department of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Oncology, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pathomorphology, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandThe aim of this study was to assess the long-term results of liver transplantation (LT) in pediatric patients with unresectable hepatoblastoma (HB) or hepatocellular carcinoma (HCC) with special reference to the risk of tumor recurrence. We retrospectively analyzed data from 46 HB and 26 HCC patients who underwent LT between 1990 and 2022. In HCC patients, we compared outcomes depending on donor type. We evaluated the impact of a number of risk factors on recurrence-free survival after LT. Estimated patient survival after 5, 10, and 15 years was 82%, 73%, and 73% in the HB group and 79%, 75%, and 75% in the HCC group, respectively (<i>p</i> = 0.76). In the HCC group, living donor LT (LDLT) and deceased donor LT (DDLT) provided similar patient survival (<i>p</i> = 0.09). Estimated recurrence-free survival in patients who had three or fewer risk factors was significantly better than in patients with more than three risk factors (<i>p</i> = 0.0001). Adequate patient selection is necessary when considering LT for primary liver tumors in children. The presence of more than three risk factors is associated with a very high risk of recurrence and indicates poor prognosis, whereas extrahepatic disease may be considered a contraindication for transplantation.https://www.mdpi.com/2227-9067/11/2/193hepatoblastomahepatocellular carcinomaliver transplantation |
| spellingShingle | Marek Stefanowicz Piotr Kaliciński Hor Ismail Adam Kowalski Dorota Broniszczak Marek Szymczak Katarzyna Pankowska-Woźniak Anna Roszkiewicz Ewa Święszkowska Diana Kamińska Sylwia Szymańska Grzegorz Kowalewski Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular Carcinoma Children hepatoblastoma hepatocellular carcinoma liver transplantation |
| title | Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular Carcinoma |
| title_full | Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular Carcinoma |
| title_fullStr | Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular Carcinoma |
| title_full_unstemmed | Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular Carcinoma |
| title_short | Risk for Recurrence in Long-Term Follow-Up of Children after Liver Transplantation for Hepatoblastoma or Hepatocellular Carcinoma |
| title_sort | risk for recurrence in long term follow up of children after liver transplantation for hepatoblastoma or hepatocellular carcinoma |
| topic | hepatoblastoma hepatocellular carcinoma liver transplantation |
| url | https://www.mdpi.com/2227-9067/11/2/193 |
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