TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
Background: Renal cell carcinoma (RCC) occasionally breaches the urothelial tissue barrier and extends into the collecting system mimicking a transitional cell carcinoma. We present a case of a TFE3-rearranged renal cell carcinoma in a young patient that extended to fill the entire upper urinary tra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Urology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442023002747 |
| _version_ | 1797399063648272384 |
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| author | Arman Z. Chacko Shweta Singh Johann Boaz Vikram Raj Gopinathan M.P. Rajadoss |
| author_facet | Arman Z. Chacko Shweta Singh Johann Boaz Vikram Raj Gopinathan M.P. Rajadoss |
| author_sort | Arman Z. Chacko |
| collection | DOAJ |
| description | Background: Renal cell carcinoma (RCC) occasionally breaches the urothelial tissue barrier and extends into the collecting system mimicking a transitional cell carcinoma. We present a case of a TFE3-rearranged renal cell carcinoma in a young patient that extended to fill the entire upper urinary tract leading to a pre-operative diagnosis of upper tract urothelial carcinoma (UTUC) based on CT imaging. A sequential algorithm of IHC/FISH assays led to the correct diagnosis of TFE3-rearranged RCC. Awareness of this potential misdiagnosis, particularly in young patients, can mitigate significant morbidity. |
| first_indexed | 2024-03-09T01:34:59Z |
| format | Article |
| id | doaj.art-35b814cf0f7a440aa8a54f9f9a186c88 |
| institution | Directory Open Access Journal |
| issn | 2214-4420 |
| language | English |
| last_indexed | 2024-03-09T01:34:59Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj.art-35b814cf0f7a440aa8a54f9f9a186c882023-12-09T06:06:09ZengElsevierUrology Case Reports2214-44202023-11-0151102588TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinomaArman Z. Chacko0Shweta Singh1Johann Boaz2Vikram Raj Gopinathan3M.P. Rajadoss4Department of Urology, Christian Medical College Vellore, India; Corresponding author.Department of Radiology, Christian Medical College Vellore, IndiaDepartment of Urology, Christian Medical College Vellore, IndiaDepartment of Pathology, Christian Medical College Vellore, IndiaDepartment of Urology, Christian Medical College Vellore, IndiaBackground: Renal cell carcinoma (RCC) occasionally breaches the urothelial tissue barrier and extends into the collecting system mimicking a transitional cell carcinoma. We present a case of a TFE3-rearranged renal cell carcinoma in a young patient that extended to fill the entire upper urinary tract leading to a pre-operative diagnosis of upper tract urothelial carcinoma (UTUC) based on CT imaging. A sequential algorithm of IHC/FISH assays led to the correct diagnosis of TFE3-rearranged RCC. Awareness of this potential misdiagnosis, particularly in young patients, can mitigate significant morbidity.http://www.sciencedirect.com/science/article/pii/S2214442023002747TFE3 renal cell carcinomaImmunohistochemistryUrothelial carcinoma |
| spellingShingle | Arman Z. Chacko Shweta Singh Johann Boaz Vikram Raj Gopinathan M.P. Rajadoss TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma Urology Case Reports TFE3 renal cell carcinoma Immunohistochemistry Urothelial carcinoma |
| title | TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma |
| title_full | TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma |
| title_fullStr | TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma |
| title_full_unstemmed | TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma |
| title_short | TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma |
| title_sort | tfe3 rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma |
| topic | TFE3 renal cell carcinoma Immunohistochemistry Urothelial carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2214442023002747 |
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