Synchronization of Spontaneous Active Motility of Hair Cell Bundles.
Hair cells of the inner ear exhibit an active process, believed to be crucial for achieving the sensitivity of auditory and vestibular detection. One of the manifestations of the active process is the occurrence of spontaneous hair bundle oscillations in vitro. Hair bundles are coupled by overlying...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4634766?pdf=render |
| _version_ | 1818316919573315584 |
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| author | Tracy-Ying Zhang Seung Ji Dolores Bozovic |
| author_facet | Tracy-Ying Zhang Seung Ji Dolores Bozovic |
| author_sort | Tracy-Ying Zhang |
| collection | DOAJ |
| description | Hair cells of the inner ear exhibit an active process, believed to be crucial for achieving the sensitivity of auditory and vestibular detection. One of the manifestations of the active process is the occurrence of spontaneous hair bundle oscillations in vitro. Hair bundles are coupled by overlying membranes in vivo; hence, explaining the potential role of innate bundle motility in the generation of otoacoustic emissions requires an understanding of the effects of coupling on the active bundle dynamics. We used microbeads to connect small groups of hair cell bundles, using in vitro preparations that maintain their innate oscillations. Our experiments demonstrate robust synchronization of spontaneous oscillations, with either 1:1 or multi-mode phase-locking. The frequency of synchronized oscillation was found to be near the mean of the innate frequencies of individual bundles. Coupling also led to an improved regularity of entrained oscillations, demonstrated by an increase in the quality factor. |
| first_indexed | 2024-12-13T09:29:05Z |
| format | Article |
| id | doaj.art-35b8f72aaf5340a39c5824cb3327d446 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T09:29:05Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-35b8f72aaf5340a39c5824cb3327d4462022-12-21T23:52:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014176410.1371/journal.pone.0141764Synchronization of Spontaneous Active Motility of Hair Cell Bundles.Tracy-Ying ZhangSeung JiDolores BozovicHair cells of the inner ear exhibit an active process, believed to be crucial for achieving the sensitivity of auditory and vestibular detection. One of the manifestations of the active process is the occurrence of spontaneous hair bundle oscillations in vitro. Hair bundles are coupled by overlying membranes in vivo; hence, explaining the potential role of innate bundle motility in the generation of otoacoustic emissions requires an understanding of the effects of coupling on the active bundle dynamics. We used microbeads to connect small groups of hair cell bundles, using in vitro preparations that maintain their innate oscillations. Our experiments demonstrate robust synchronization of spontaneous oscillations, with either 1:1 or multi-mode phase-locking. The frequency of synchronized oscillation was found to be near the mean of the innate frequencies of individual bundles. Coupling also led to an improved regularity of entrained oscillations, demonstrated by an increase in the quality factor.http://europepmc.org/articles/PMC4634766?pdf=render |
| spellingShingle | Tracy-Ying Zhang Seung Ji Dolores Bozovic Synchronization of Spontaneous Active Motility of Hair Cell Bundles. PLoS ONE |
| title | Synchronization of Spontaneous Active Motility of Hair Cell Bundles. |
| title_full | Synchronization of Spontaneous Active Motility of Hair Cell Bundles. |
| title_fullStr | Synchronization of Spontaneous Active Motility of Hair Cell Bundles. |
| title_full_unstemmed | Synchronization of Spontaneous Active Motility of Hair Cell Bundles. |
| title_short | Synchronization of Spontaneous Active Motility of Hair Cell Bundles. |
| title_sort | synchronization of spontaneous active motility of hair cell bundles |
| url | http://europepmc.org/articles/PMC4634766?pdf=render |
| work_keys_str_mv | AT tracyyingzhang synchronizationofspontaneousactivemotilityofhaircellbundles AT seungji synchronizationofspontaneousactivemotilityofhaircellbundles AT doloresbozovic synchronizationofspontaneousactivemotilityofhaircellbundles |