Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage
Date palm fruit seed (<i>Phoenix dactylifera</i> L.) extract (DSE), an under-utilized resource, is a rich source of polyphenols with high potency for disease prevention and antioxidative activities. For the first time, the present study demonstrated that DSE inhibits labile iron activity...
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MDPI AG
2022-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/17/3536 |
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| author | Hosam M. Habib Esmail M. El-Fakharany Usama D. Souka Fatma M. Elsebaee Mohamed G. El-Ziney Wissam H. Ibrahim |
| author_facet | Hosam M. Habib Esmail M. El-Fakharany Usama D. Souka Fatma M. Elsebaee Mohamed G. El-Ziney Wissam H. Ibrahim |
| author_sort | Hosam M. Habib |
| collection | DOAJ |
| description | Date palm fruit seed (<i>Phoenix dactylifera</i> L.) extract (DSE), an under-utilized resource, is a rich source of polyphenols with high potency for disease prevention and antioxidative activities. For the first time, the present study demonstrated that DSE inhibits labile iron activity and DNA and BSA damage and inhibits acetylcholinesterase and tyrosinase activities. Moreover, DSE reduces the proliferation of hepatic, colorectal, and breast cancer cells dose-dependently through apoptotic mechanisms. Furthermore, DSE significantly suppressed the expression of both BCl-2 and P21 genes and increased the P53 expression level when compared with the untreated cells and the 5-FU treated cells. These findings suggest a strong potential for DSE in protecting against the iron-catalyzed ferroptosis that results in programmed cell death. The results also confirm the efficacy of DSE against cancer cells. Therefore, DSE constitutes a valuable candidate for developing functional foods and for natural compound-based chemotherapy for the pharmaceutical and nutraceutical industries. |
| first_indexed | 2024-03-10T01:25:39Z |
| format | Article |
| id | doaj.art-35b9616c92564764b0d043920252d129 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T01:25:39Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-35b9616c92564764b0d043920252d1292023-11-23T13:52:04ZengMDPI AGNutrients2072-66432022-08-011417353610.3390/nu14173536Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein DamageHosam M. Habib0Esmail M. El-Fakharany1Usama D. Souka2Fatma M. Elsebaee3Mohamed G. El-Ziney4Wissam H. Ibrahim5Functional Foods and Nutraceuticals Laboratory (FFNL), Dairy Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria P.O. Box 21545, EgyptProtein Research Department, Genetic Engineering and Biotechnology Research Institute GEBRI, City for Scientific Research and Technology Applications, New Borg EL Arab, Alexandria P.O. Box 21934, EgyptDepartment of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesDepartment of Home Economics, Faculty of Specific Education, Fayoum University, Fayoum P.O. Box 63514, EgyptFunctional Foods and Nutraceuticals Laboratory (FFNL), Dairy Science and Technology Department, Faculty of Agriculture, Alexandria University, Alexandria P.O. Box 21545, EgyptDepartment of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab EmiratesDate palm fruit seed (<i>Phoenix dactylifera</i> L.) extract (DSE), an under-utilized resource, is a rich source of polyphenols with high potency for disease prevention and antioxidative activities. For the first time, the present study demonstrated that DSE inhibits labile iron activity and DNA and BSA damage and inhibits acetylcholinesterase and tyrosinase activities. Moreover, DSE reduces the proliferation of hepatic, colorectal, and breast cancer cells dose-dependently through apoptotic mechanisms. Furthermore, DSE significantly suppressed the expression of both BCl-2 and P21 genes and increased the P53 expression level when compared with the untreated cells and the 5-FU treated cells. These findings suggest a strong potential for DSE in protecting against the iron-catalyzed ferroptosis that results in programmed cell death. The results also confirm the efficacy of DSE against cancer cells. Therefore, DSE constitutes a valuable candidate for developing functional foods and for natural compound-based chemotherapy for the pharmaceutical and nutraceutical industries.https://www.mdpi.com/2072-6643/14/17/3536date seed extractlabile iron inhibitionDNA and BSA damageenzyme inhibitionanticancer |
| spellingShingle | Hosam M. Habib Esmail M. El-Fakharany Usama D. Souka Fatma M. Elsebaee Mohamed G. El-Ziney Wissam H. Ibrahim Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage Nutrients date seed extract labile iron inhibition DNA and BSA damage enzyme inhibition anticancer |
| title | Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage |
| title_full | Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage |
| title_fullStr | Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage |
| title_full_unstemmed | Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage |
| title_short | Polyphenol-Rich Date Palm Fruit Seed (<i>Phoenix Dactylifera</i> L.) Extract Inhibits Labile Iron, Enzyme, and Cancer Cell Activities, and DNA and Protein Damage |
| title_sort | polyphenol rich date palm fruit seed i phoenix dactylifera i l extract inhibits labile iron enzyme and cancer cell activities and dna and protein damage |
| topic | date seed extract labile iron inhibition DNA and BSA damage enzyme inhibition anticancer |
| url | https://www.mdpi.com/2072-6643/14/17/3536 |
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