Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs
For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins. To analyze the kinases that mediate these phosphorylations, eggs of marine nemertean worms have been treated with pharmacological modulators of i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-08-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/8/8/2417/ |
| _version_ | 1798041651063554048 |
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| author | Alicia Marquardt Samuel Abernathy Jose R. Escalona Stephen A. Stricker |
| author_facet | Alicia Marquardt Samuel Abernathy Jose R. Escalona Stephen A. Stricker |
| author_sort | Alicia Marquardt |
| collection | DOAJ |
| description | For development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins. To analyze the kinases that mediate these phosphorylations, eggs of marine nemertean worms have been treated with pharmacological modulators of intracellular signaling pathways and subsequently probed with immunoblots employing phospho-specific antibodies. This article both reviews such analyses and compares them with those conducted on mammals, while focusing on how egg maturation in nemerteans is affected by signaling pathways involving cAMP, mitogen-activated protein kinases, Src-family kinases, protein kinase C isotypes, AMP-activated kinase, and the Cdc2 kinase of maturation-promoting factor. |
| first_indexed | 2024-04-11T22:24:30Z |
| format | Article |
| id | doaj.art-35b97205c62f4caa9742f7091e4b0cfb |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:24:30Z |
| publishDate | 2010-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-35b97205c62f4caa9742f7091e4b0cfb2022-12-22T03:59:48ZengMDPI AGMarine Drugs1660-33972010-08-01882417243410.3390/md8082417Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian EggsAlicia MarquardtSamuel AbernathyJose R. EscalonaStephen A. StrickerFor development to proceed normally, animal eggs must undergo a maturation process that ultimately depends on phosphorylations of key regulatory proteins. To analyze the kinases that mediate these phosphorylations, eggs of marine nemertean worms have been treated with pharmacological modulators of intracellular signaling pathways and subsequently probed with immunoblots employing phospho-specific antibodies. This article both reviews such analyses and compares them with those conducted on mammals, while focusing on how egg maturation in nemerteans is affected by signaling pathways involving cAMP, mitogen-activated protein kinases, Src-family kinases, protein kinase C isotypes, AMP-activated kinase, and the Cdc2 kinase of maturation-promoting factor.http://www.mdpi.com/1660-3397/8/8/2417/GVBDAMPKMPF |
| spellingShingle | Alicia Marquardt Samuel Abernathy Jose R. Escalona Stephen A. Stricker Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs Marine Drugs GVBD AMPK MPF |
| title | Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs |
| title_full | Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs |
| title_fullStr | Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs |
| title_full_unstemmed | Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs |
| title_short | Pharmacological Analyses of Protein Kinases Regulating Egg Maturation in Marine Nemertean Worms: A Review and Comparison with Mammalian Eggs |
| title_sort | pharmacological analyses of protein kinases regulating egg maturation in marine nemertean worms a review and comparison with mammalian eggs |
| topic | GVBD AMPK MPF |
| url | http://www.mdpi.com/1660-3397/8/8/2417/ |
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