Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response
Epstein-Barr virus (EBV)-positive gastric adenocarcinoma exhibits locally intense inflammation but systemic manifestations are uncertain. Our study examined whether circulating mediators of inflammation and immune response differ by tumor EBV status. From a Latvian series of 302 gastric cancer cases...
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MDPI AG
2018-08-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/10/9/284 |
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| author | M. Constanza Camargo Armands Sivins Sergejs Isajevs Valdis Folkmanis Dace Rudzīte Margaret L. Gulley G. Johan Offerhaus Marcis Leja Charles S. Rabkin |
| author_facet | M. Constanza Camargo Armands Sivins Sergejs Isajevs Valdis Folkmanis Dace Rudzīte Margaret L. Gulley G. Johan Offerhaus Marcis Leja Charles S. Rabkin |
| author_sort | M. Constanza Camargo |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV)-positive gastric adenocarcinoma exhibits locally intense inflammation but systemic manifestations are uncertain. Our study examined whether circulating mediators of inflammation and immune response differ by tumor EBV status. From a Latvian series of 302 gastric cancer cases, we measured plasma levels of 92 immune-related proteins in the 28 patients with EBV-positive tumors and 34 patients with EBV-negative tumors. Eight markers were statistically significantly higher with tumor EBV positivity: chemokine C-C motif ligand (CCL) 20 (Odds Ratio (OR) = 3.6; p-trend = 0.001), chemokine C-X-C motif ligand 9 (OR = 3.6; p-trend = 0.003), programmed death-ligand 1 (PD-L1; OR = 3.4; p-trend = 0.004), interleukin (IL)-10 (OR = 2.4; p-trend = 0.019), CCL19 (OR = 2.3; p-trend = 0.019), CCL11 (OR = 2.2; p-trend = 0.026), IL-17A (OR = 2.0; p-trend = 0.038) and CCL8 (OR = 1.9; p-trend = 0.049). Systemic responses to EBV-positive gastric cancer are characterized by alterations in chemokines and PD-L1. Profiling of these molecules may enable non-invasive diagnosis of EBV status when tumor tissue is unavailable. Our findings provide theoretical justification for clinical evaluations of immune checkpoint therapy for EBV-positive gastric cancer. |
| first_indexed | 2024-03-12T04:14:47Z |
| format | Article |
| id | doaj.art-35ba80d1c6904118a471b1b026e07e7d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T04:14:47Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-35ba80d1c6904118a471b1b026e07e7d2023-09-03T10:41:32ZengMDPI AGCancers2072-66942018-08-0110928410.3390/cancers10090284cancers10090284Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune ResponseM. Constanza Camargo0Armands Sivins1Sergejs Isajevs2Valdis Folkmanis3Dace Rudzīte4Margaret L. Gulley5G. Johan Offerhaus6Marcis Leja7Charles S. Rabkin8Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Dr., BG 9609/6E338, Bethesda, MD 20892, USAInstitute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, LV1586 Riga, LatviaInstitute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, LV1586 Riga, LatviaInstitute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, LV1586 Riga, LatviaInstitute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, LV1586 Riga, LatviaDepartment of Pathology, University of North Carolina, Chapel Hill, NC 27599, USADepartment of Pathology, University Medical Center Utrecht, 3508 GA Utrecht, The NetherlandsInstitute of Clinical and Preventive Medicine and Faculty of Medicine, University of Latvia, LV1586 Riga, LatviaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Dr., BG 9609/6E338, Bethesda, MD 20892, USAEpstein-Barr virus (EBV)-positive gastric adenocarcinoma exhibits locally intense inflammation but systemic manifestations are uncertain. Our study examined whether circulating mediators of inflammation and immune response differ by tumor EBV status. From a Latvian series of 302 gastric cancer cases, we measured plasma levels of 92 immune-related proteins in the 28 patients with EBV-positive tumors and 34 patients with EBV-negative tumors. Eight markers were statistically significantly higher with tumor EBV positivity: chemokine C-C motif ligand (CCL) 20 (Odds Ratio (OR) = 3.6; p-trend = 0.001), chemokine C-X-C motif ligand 9 (OR = 3.6; p-trend = 0.003), programmed death-ligand 1 (PD-L1; OR = 3.4; p-trend = 0.004), interleukin (IL)-10 (OR = 2.4; p-trend = 0.019), CCL19 (OR = 2.3; p-trend = 0.019), CCL11 (OR = 2.2; p-trend = 0.026), IL-17A (OR = 2.0; p-trend = 0.038) and CCL8 (OR = 1.9; p-trend = 0.049). Systemic responses to EBV-positive gastric cancer are characterized by alterations in chemokines and PD-L1. Profiling of these molecules may enable non-invasive diagnosis of EBV status when tumor tissue is unavailable. Our findings provide theoretical justification for clinical evaluations of immune checkpoint therapy for EBV-positive gastric cancer.http://www.mdpi.com/2072-6694/10/9/284chemokinesEBVgastric cancerinflammationPD-L1 |
| spellingShingle | M. Constanza Camargo Armands Sivins Sergejs Isajevs Valdis Folkmanis Dace Rudzīte Margaret L. Gulley G. Johan Offerhaus Marcis Leja Charles S. Rabkin Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response Cancers chemokines EBV gastric cancer inflammation PD-L1 |
| title | Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response |
| title_full | Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response |
| title_fullStr | Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response |
| title_full_unstemmed | Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response |
| title_short | Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response |
| title_sort | associations of epstein barr virus positive gastric adenocarcinoma with circulating mediators of inflammation and immune response |
| topic | chemokines EBV gastric cancer inflammation PD-L1 |
| url | http://www.mdpi.com/2072-6694/10/9/284 |
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