Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 cases
Objective: We aimed to investigate the use of core needle biopsy (CNB) in epididymal tuberculosis (TB) diagnosis. Methods: We analyzed 41 samples collected between January 1, 2018, and January 31, 2021, from patients who underwent CNB for suspected epididymal TB. All specimens were examined using hi...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971222003083 |
| _version_ | 1817995108086185984 |
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| author | Pengju Liu Hai Gu Yuan Liu Yong Qin |
| author_facet | Pengju Liu Hai Gu Yuan Liu Yong Qin |
| author_sort | Pengju Liu |
| collection | DOAJ |
| description | Objective: We aimed to investigate the use of core needle biopsy (CNB) in epididymal tuberculosis (TB) diagnosis. Methods: We analyzed 41 samples collected between January 1, 2018, and January 31, 2021, from patients who underwent CNB for suspected epididymal TB. All specimens were examined using histopathological examination and the Xpert Mycobacterium tuberculosis bacilli/rifampicin (MTB/RIF) assay. We analyzed the examination results to determine the application value of CNB in epididymal TB diagnosis and evaluate its safety. Results: According to the comprehensive reference standard established in this study, 37 of the 41 patients had epididymal TB and four patients had chronic epididymitis. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of histopathological examination were 86.49% (71.23-95.46%), 100.00% (39.76-100.00%), 100.00% (89.11-100.00%), 44.44% (13.70-78.80%), and 0.93 (0.81-0.99), respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of the Xpert MTB/RIF assay were 62.16% (44.76-77.54%), 100.00% (39.76-100.00%), 100.00% (85.18-100.00%), 22.22% (6.41-47.76%), and 0.81 (0.66-0.92), respectively. No postoperative complication attained a Clavien–Dindo classification grade of >2. Conclusion: CNB was useful in diagnosing epididymal TB. Therefore, we recommend using CNB as a sample collection tool for diagnosing epididymal TB. |
| first_indexed | 2024-04-14T02:01:12Z |
| format | Article |
| id | doaj.art-35bbe9231d224f86898423bca17f7a9a |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-14T02:01:12Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-35bbe9231d224f86898423bca17f7a9a2022-12-22T02:18:50ZengElsevierInternational Journal of Infectious Diseases1201-97122022-09-011223337Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 casesPengju Liu0Hai Gu1Yuan Liu2Yong Qin3Department of Urology, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urology, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Urology, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaCorresponding author: Yong Qin, Department of Urology, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, 208 East Huancheng Road, Hangzhou, China. Phone number: 86571-56108764.; Department of Urology, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaObjective: We aimed to investigate the use of core needle biopsy (CNB) in epididymal tuberculosis (TB) diagnosis. Methods: We analyzed 41 samples collected between January 1, 2018, and January 31, 2021, from patients who underwent CNB for suspected epididymal TB. All specimens were examined using histopathological examination and the Xpert Mycobacterium tuberculosis bacilli/rifampicin (MTB/RIF) assay. We analyzed the examination results to determine the application value of CNB in epididymal TB diagnosis and evaluate its safety. Results: According to the comprehensive reference standard established in this study, 37 of the 41 patients had epididymal TB and four patients had chronic epididymitis. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of histopathological examination were 86.49% (71.23-95.46%), 100.00% (39.76-100.00%), 100.00% (89.11-100.00%), 44.44% (13.70-78.80%), and 0.93 (0.81-0.99), respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve of the Xpert MTB/RIF assay were 62.16% (44.76-77.54%), 100.00% (39.76-100.00%), 100.00% (85.18-100.00%), 22.22% (6.41-47.76%), and 0.81 (0.66-0.92), respectively. No postoperative complication attained a Clavien–Dindo classification grade of >2. Conclusion: CNB was useful in diagnosing epididymal TB. Therefore, we recommend using CNB as a sample collection tool for diagnosing epididymal TB.http://www.sciencedirect.com/science/article/pii/S1201971222003083Clinical diagnosisEpididymal tuberculosisCNBXpert MTB/RIF assay |
| spellingShingle | Pengju Liu Hai Gu Yuan Liu Yong Qin Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 cases International Journal of Infectious Diseases Clinical diagnosis Epididymal tuberculosis CNB Xpert MTB/RIF assay |
| title | Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 cases |
| title_full | Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 cases |
| title_fullStr | Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 cases |
| title_full_unstemmed | Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 cases |
| title_short | Application of core needle biopsy in the diagnosis of epididymal tuberculosis: a retrospective analysis of 41 cases |
| title_sort | application of core needle biopsy in the diagnosis of epididymal tuberculosis a retrospective analysis of 41 cases |
| topic | Clinical diagnosis Epididymal tuberculosis CNB Xpert MTB/RIF assay |
| url | http://www.sciencedirect.com/science/article/pii/S1201971222003083 |
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