$A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model$

A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model

Zheng Wang, Yong Zhao, Dong Zhang, Baiwen Qi, Weidong Xiao, Xiang Hu, Aixi Yu Department of Orthopaedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, People’s Republic of China Purpose: LLP2A-alendronate (LLP2A-Ale) is a novel bone-seeking compound...

Full description

Bibliographic Details
Main Authors:	Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A
Format:	Article
Language:	English
Published:	Dove Medical Press 2019-04-01
Series:	Drug Design, Development and Therapy
Subjects:	Osteogenesis drug Fracture healing Angiogenesis Osteogenesis Rabbit fracture model
Online Access:	https://www.dovepress.com/a-novel-hybrid-compound-llp2a-alendronate-accelerates-open-fracture-he-peer-reviewed-article-DDDT

Similar Items

Irisin promotes fracture healing by improving osteogenesis and angiogenesis
by: Tianyou Kan, et al.
Published: (2022-11-01)

Ginsenoside Compound K Enhances Fracture Healing via Promoting Osteogenesis and Angiogenesis
by: Lingli Ding, et al.
Published: (2022-04-01)

Fueling recovery: The importance of energy coupling between angiogenesis and osteogenesis during fracture healing
by: Fleur van Brakel, et al.
Published: (2024-06-01)

Bone morphogenetic protein-7: Review of signalling and efficacy in fracture healing
by: Steven Cecchi, et al.
Published: (2016-01-01)

Cryopreserved human adipose-derived stromal vascular fraction maintains fracture healing potential via angiogenesis and osteogenesis in an immunodeficient rat model
by: Tomoyuki Kamenaga, et al.
Published: (2021-02-01)

Cyasterone accelerates fracture healing by promoting MSCs migration and osteogenesis
by: Junlang Zhu, et al.
Published: (2021-05-01)

The Results of the Treatment of Osteogenesis Imperfecta with Corkscrew Tipped Telescopic Nail
by: Hüseyin Günay, et al.
Published: (2017-03-01)

A new bone adhesive to fix mandible fractures in New Zealand rabbits: cytotoxicity assay and comparison of bone formation with conventional plate and screw method
by: Reza Sharifi, et al.
Published: (2023-07-01)

Physiological role of growth factors and bone morphogenetic proteins in osteogenesis and bone fracture healing: а review
by: S. Sagalovsky
Published: (2016-02-01)

Barium Oxide Doped Magnesium Silicate Nanopowders for Bone Fracture Healing: Preparation, Characterization, Antibacterial and In Vivo Animal Studies
by: Mostafa Mabrouk, et al.
Published: (2022-07-01)

Biodegradable magnesium pins enhanced the healing of transverse patellar fracture in rabbits
by: Dick Ho Kiu Chow, et al.
Published: (2021-11-01)

PTH-Induced Bone Regeneration and Vascular Modulation Are Both Dependent on Endothelial Signaling
by: Doron Cohn-Schwartz, et al.
Published: (2022-03-01)

Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta
by: Bin Sun, et al.
Published: (2023-01-01)

Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion
by: Lu Zhang, et al.
Published: (2020-01-01)

Bone Fractures Numerical Analysis in a Femur Affected by Osteogenesis Imperfecta
by: Viridiana Ramírez-Vela, et al.
Published: (2021-12-01)

Osteogenesis Imperfecta Presented with Vertebral Fractures After Pregnancy and Treatment with Cyclical Etidronate: A Case Report
by: Cengiz Bahadır, et al.
Published: (2005-06-01)

The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing
by: Fuxian Lv, et al.
Published: (2023-05-01)

Differentiated Stem Cells Derived from Rabbit Adipose Tissue Exhibited in ‎Vitro Adipogenesis and Osteogenesis
by: Dhurgham H Al-Haideri, et al.
Published: (2023-12-01)

Intramedullary Nailing of Deformity and Fracture in a Patient with Osteogenesis Imperfecta
by: Hasan Göçer, et al.
Published: (2014-06-01)

A Novel Hybrid Compound LLP2A-Alendronate Accelerates Open Fracture Healing in a Rabbit Model [Corrigendum]
by: Wang Z, et al.
Published: (2019-12-01)

Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic
by: Simone Amber Munk, et al.
Published: (2022-12-01)

Intrauterine bone fractures in fetuses with osteogenesis imperfecta: a literature review and a case report
by: Evgenii G. Skryabin, et al.
Published: (2018-12-01)

Exosomes Derived from Adipose Stem Cells Enhance Bone Fracture Healing via the Activation of the Wnt3a/β-Catenin Signaling Pathway in Rats with Type 2 Diabetes Mellitus
by: Dong Zhang, et al.
Published: (2023-03-01)

Regenerative Effects of Three Types of Allografts on Rabbit Calvarium: An Animal Study
by: Amir Reza Rokn, et al.
Published: (2016-08-01)

The expressions of NGF and VEGF in the fracture tissues are closely associated with accelerated clavicle fracture healing in patients with traumatic brain injury
by: Zhang R, et al.
Published: (2018-11-01)

Flunixin Meglumine Enhanced Bone Fracture Healing in Rabbits Associated with Activation of Early Collagen Deposition and Enhancement of Vascular Endothelial Growth Factor Expression
by: Mohamed Elgendy, et al.
Published: (2021-09-01)

Current Application of Beta-Tricalcium Phosphate in Bone Repair and Its Mechanism to Regulate Osteogenesis
by: Haiping Lu, et al.
Published: (2021-07-01)

The Natural History of Symptomatic Fractures in Children and Adolescents with Osteogenesis Imperfecta Type 1: A Cohort Study from Western Australia
by: Kiranjit K Joshi, et al.
Published: (2023-09-01)

THE EFFECT OF DENERVATION ON FRACTURE HEALING , AN EXPERIMENTAL STUDY ON RABBITS
by: THAMIR A. HAMDAN, et al.
Published: (2014-12-01)

An FGFR2 mutation as the potential cause of a new phenotype including early-onset osteoporosis and bone fractures: a case report
by: Ilya S Dantsev, et al.
Published: (2023-12-01)

Bone transport for limb reconstruction following severe tibial fractures
by: Julian Fürmetz, et al.
Published: (2016-03-01)

Surgical management of an acetabular fracture in type- I osteogenesis imperfecta through a modified Stoppa approach - A case report and literature review
by: Ali Fergany, et al.
Published: (2023-12-01)

A boy with blue sclera and recurrent fractures
by: Norasnieda Md Shukri, et al.
Published: (2015-07-01)

Application of means of stimulation of regenerative osteogenesis for complex treatment of dogs with fractures of the limb bones
by: V. S. Dmitrijev, et al.
Published: (2018-12-01)

Effect of low-intensity pulsed ultrasound on distraction osteogenesis: a systematic review and meta-analysis of randomized controlled trials
by: Shenghan Lou, et al.
Published: (2018-08-01)

Fixation techniques in lower extremity correction osteotomies and fractures in mild-to-severe osteogenesis imperfecta patients: evaluation of the results and complications
by: Abdulsamet Emet, et al.
Published: (2023-06-01)

Generation of Open Metatarsal Fracture in Rats: A Model for Secondary Fracture Healing
by: Adamu Abdul Abubakar, et al.
Published: (2020-12-01)

Open Osteotomy of ulna as a Model For Fracture Healing Studies in Rabbits.
by: Mahmood A. Aljumaily
Published: (2010-10-01)

Effects of Low Intensity Pulsed Ultrasound Stimulation on the Temporal Dynamics of Irradiated Bone Tissue Healing: A Histomorphometric Study in Rabbits
by: Bob Biewer, et al.
Published: (2022-10-01)

Fetal Fractures in an Infant with Maternal Ehlers-Danlos Syndrome, CCDC134 Pathogenic Mutation and a Negative Genetic Test for Osteogenesis Imperfecta
by: Michael F. Holick, et al.
Published: (2021-06-01)