D-serine increases adult hippocampal neurogenesis
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new neurons and a major contributor to the neurog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-08-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00155/full |
| _version_ | 1819113270655582208 |
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| author | Sebastien eSultan Elias Georges Gebara Kristell eMoullec Nicolas eToni |
| author_facet | Sebastien eSultan Elias Georges Gebara Kristell eMoullec Nicolas eToni |
| author_sort | Sebastien eSultan |
| collection | DOAJ |
| description | Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new neurons and a major contributor to the neurogenic niche are astrocytes. Among the molecules secreted by astrocytes, D-serine is an important gliotransmitter and is a co-agonist of the glutamate, N-methyl-D-aspartate (NMDA) receptor. D-serine has been shown to enhance the proliferation of neural stem cells in vitro, but its effect on adult neurogenesis in vivo is unknown. Here, we tested the effect of exogenous administration of D-serine on adult neurogenesis in the mouse dentate gyrus. We found that 1 week of treatment with D-serine increased cell proliferation in vivo and in vitro and increased the density of neural stem cells and transit amplifying progenitors. Furthermore, D-serine increased the survival of newborn neurons. Together, these results indicate that D-serine treatment resulted in the improvement of several steps of adult neurogenesis in vivo. |
| first_indexed | 2024-12-22T04:26:44Z |
| format | Article |
| id | doaj.art-35be1d06e1dd4131ae5eaaf73ee19393 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T04:26:44Z |
| publishDate | 2013-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-35be1d06e1dd4131ae5eaaf73ee193932022-12-21T18:39:08ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2013-08-01710.3389/fnins.2013.0015558044D-serine increases adult hippocampal neurogenesisSebastien eSultan0Elias Georges Gebara1Kristell eMoullec2Nicolas eToni3University of LausanneUniversity of LausanneUniversity of LausanneUniversity of LausanneAdult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new neurons and a major contributor to the neurogenic niche are astrocytes. Among the molecules secreted by astrocytes, D-serine is an important gliotransmitter and is a co-agonist of the glutamate, N-methyl-D-aspartate (NMDA) receptor. D-serine has been shown to enhance the proliferation of neural stem cells in vitro, but its effect on adult neurogenesis in vivo is unknown. Here, we tested the effect of exogenous administration of D-serine on adult neurogenesis in the mouse dentate gyrus. We found that 1 week of treatment with D-serine increased cell proliferation in vivo and in vitro and increased the density of neural stem cells and transit amplifying progenitors. Furthermore, D-serine increased the survival of newborn neurons. Together, these results indicate that D-serine treatment resulted in the improvement of several steps of adult neurogenesis in vivo.http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00155/fullAstrocytesDentate GyrusStem Cell FactorStem Cell Nicheadult neurogenesisd-serine |
| spellingShingle | Sebastien eSultan Elias Georges Gebara Kristell eMoullec Nicolas eToni D-serine increases adult hippocampal neurogenesis Frontiers in Neuroscience Astrocytes Dentate Gyrus Stem Cell Factor Stem Cell Niche adult neurogenesis d-serine |
| title | D-serine increases adult hippocampal neurogenesis |
| title_full | D-serine increases adult hippocampal neurogenesis |
| title_fullStr | D-serine increases adult hippocampal neurogenesis |
| title_full_unstemmed | D-serine increases adult hippocampal neurogenesis |
| title_short | D-serine increases adult hippocampal neurogenesis |
| title_sort | d serine increases adult hippocampal neurogenesis |
| topic | Astrocytes Dentate Gyrus Stem Cell Factor Stem Cell Niche adult neurogenesis d-serine |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00155/full |
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