Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair
Hydrogel products for chronic diabetic wounds, a serious and prevalent complication of diabetes, show limited effects on disability and remain nonspecific. Thus, improvements in the usage of pharmaceutical molecule in the hydrogels are highly desirable to increase the therapeutic effect of hydrogels...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-07-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22003188 |
| _version_ | 1797861071488286720 |
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| author | Chunxiao Chai Pengfei Zhang Lin Ma Qi Fan Zhicheng Liu Xiang Cheng Yunpeng Zhao Weiwei Li Jingcheng Hao |
| author_facet | Chunxiao Chai Pengfei Zhang Lin Ma Qi Fan Zhicheng Liu Xiang Cheng Yunpeng Zhao Weiwei Li Jingcheng Hao |
| author_sort | Chunxiao Chai |
| collection | DOAJ |
| description | Hydrogel products for chronic diabetic wounds, a serious and prevalent complication of diabetes, show limited effects on disability and remain nonspecific. Thus, improvements in the usage of pharmaceutical molecule in the hydrogels are highly desirable to increase the therapeutic effect of hydrogels. In this study, thioctic acid (a common medicine molecule in diabetes treatment) is used for preparing regenerative antibacterial hydrogels (RAH) which contains in situ synthesized silver nanoparticles (AgNPs). The RAH shows regenerative, self-healing and injectable ability, because of the reversible hydrogen and coordination bonds. With good regenerative capacity, RAH can be stored as powder to avoid the water loss and facilitate storage availability. Owing to the antioxidant properties of thioctic acid, the RAH can decrease the oxidative damage and retain cell proliferation efficiency. Due to the in situ synthesized AgNPs, the RAH also exhibits extraordinary antimicrobial capacities against MDR bacteria. All of these superiorities enable RAH to be a promising therapy for chronic diabetic wounds. |
| first_indexed | 2024-04-09T21:56:09Z |
| format | Article |
| id | doaj.art-35be361588824fb9bd38c2602b2f44b1 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-09T21:56:09Z |
| publishDate | 2023-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-35be361588824fb9bd38c2602b2f44b12023-03-24T04:23:02ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-07-0125541554Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repairChunxiao Chai0Pengfei Zhang1Lin Ma2Qi Fan3Zhicheng Liu4Xiang Cheng5Yunpeng Zhao6Weiwei Li7Jingcheng Hao8Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, 250100, PR ChinaDepartment of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China; Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China; Laboratory of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR ChinaKey Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, 250100, PR ChinaKey Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, 250100, PR ChinaCheeloo College of Medicine, Shandong University, Jinan, 250012, PR ChinaCheeloo College of Medicine, Shandong University, Jinan, 250012, PR ChinaDepartment of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China; Corresponding author.Department of Pathology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China; Corresponding author.Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan, 250100, PR China; Corresponding author.Hydrogel products for chronic diabetic wounds, a serious and prevalent complication of diabetes, show limited effects on disability and remain nonspecific. Thus, improvements in the usage of pharmaceutical molecule in the hydrogels are highly desirable to increase the therapeutic effect of hydrogels. In this study, thioctic acid (a common medicine molecule in diabetes treatment) is used for preparing regenerative antibacterial hydrogels (RAH) which contains in situ synthesized silver nanoparticles (AgNPs). The RAH shows regenerative, self-healing and injectable ability, because of the reversible hydrogen and coordination bonds. With good regenerative capacity, RAH can be stored as powder to avoid the water loss and facilitate storage availability. Owing to the antioxidant properties of thioctic acid, the RAH can decrease the oxidative damage and retain cell proliferation efficiency. Due to the in situ synthesized AgNPs, the RAH also exhibits extraordinary antimicrobial capacities against MDR bacteria. All of these superiorities enable RAH to be a promising therapy for chronic diabetic wounds.http://www.sciencedirect.com/science/article/pii/S2452199X22003188Diabetic wound healingAntibacterial hydrogelThioctic acidAntioxidantRegeneration |
| spellingShingle | Chunxiao Chai Pengfei Zhang Lin Ma Qi Fan Zhicheng Liu Xiang Cheng Yunpeng Zhao Weiwei Li Jingcheng Hao Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair Bioactive Materials Diabetic wound healing Antibacterial hydrogel Thioctic acid Antioxidant Regeneration |
| title | Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair |
| title_full | Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair |
| title_fullStr | Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair |
| title_full_unstemmed | Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair |
| title_short | Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair |
| title_sort | regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair |
| topic | Diabetic wound healing Antibacterial hydrogel Thioctic acid Antioxidant Regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22003188 |
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