DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers
Introduction: Combination vaccines reduce the ‘shot burden’ and simplify the childhood immunization schedule. Only 5-valent DTaP-based vaccines are licensed in the U.S. Areas covered: A new combination vaccine – DTaP5-IPV-Hib-HepB – is described, which induces antibody responses in infants (given in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-02-01
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| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1268920 |
| _version_ | 1797680407386259456 |
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| author | Andrew W. Lee Emilia Jordanov Florence Boisnard Gary S. Marshall |
| author_facet | Andrew W. Lee Emilia Jordanov Florence Boisnard Gary S. Marshall |
| author_sort | Andrew W. Lee |
| collection | DOAJ |
| description | Introduction: Combination vaccines reduce the ‘shot burden’ and simplify the childhood immunization schedule. Only 5-valent DTaP-based vaccines are licensed in the U.S. Areas covered: A new combination vaccine – DTaP5-IPV-Hib-HepB – is described, which induces antibody responses in infants (given in different schedules, including a 2, 4, and 6-month schedule) that are similar to the respective component vaccines. The vaccine appears to be safe and would be expected to protect against six diseases: diphtheria, tetanus, pertussis, hepatitis B, H influenzae type b, and polio. Administration is associated with higher rates of mild fever, but without significant safety signals. Expert commentary: Incorporation of this hexavalent vaccine into the U.S. schedule could improve coverage rates and timeliness, and addition to the E.U. market would add depth to the available repertoire of combination vaccines. |
| first_indexed | 2024-03-11T23:29:34Z |
| format | Article |
| id | doaj.art-35bede5c3c2746f6a81bdcabdae6e7af |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:34Z |
| publishDate | 2017-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-35bede5c3c2746f6a81bdcabdae6e7af2023-09-20T10:18:02ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-02-01162859210.1080/14760584.2017.12689201268920DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlersAndrew W. Lee0Emilia Jordanov1Florence Boisnard2Gary S. Marshall3Merck & Co., Inc.Sanofi PasteurSanofi Pasteur MSDUniversity of LouisvilleIntroduction: Combination vaccines reduce the ‘shot burden’ and simplify the childhood immunization schedule. Only 5-valent DTaP-based vaccines are licensed in the U.S. Areas covered: A new combination vaccine – DTaP5-IPV-Hib-HepB – is described, which induces antibody responses in infants (given in different schedules, including a 2, 4, and 6-month schedule) that are similar to the respective component vaccines. The vaccine appears to be safe and would be expected to protect against six diseases: diphtheria, tetanus, pertussis, hepatitis B, H influenzae type b, and polio. Administration is associated with higher rates of mild fever, but without significant safety signals. Expert commentary: Incorporation of this hexavalent vaccine into the U.S. schedule could improve coverage rates and timeliness, and addition to the E.U. market would add depth to the available repertoire of combination vaccines.http://dx.doi.org/10.1080/14760584.2017.1268920diphtheriatetanuspertussispoliohibhepatitis bhexavalentvaccinesafetyimmunogenicitycombination vaccine |
| spellingShingle | Andrew W. Lee Emilia Jordanov Florence Boisnard Gary S. Marshall DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers Expert Review of Vaccines diphtheria tetanus pertussis polio hib hepatitis b hexavalent vaccine safety immunogenicity combination vaccine |
| title | DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers |
| title_full | DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers |
| title_fullStr | DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers |
| title_full_unstemmed | DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers |
| title_short | DTaP5-IPV-Hib-HepB, a hexavalent vaccine for infants and toddlers |
| title_sort | dtap5 ipv hib hepb a hexavalent vaccine for infants and toddlers |
| topic | diphtheria tetanus pertussis polio hib hepatitis b hexavalent vaccine safety immunogenicity combination vaccine |
| url | http://dx.doi.org/10.1080/14760584.2017.1268920 |
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