Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story
<p>Abstract</p> <p>This review provides an update on the current state of pharmacogenetic research in the treatment of Alzheimer's disease (AD) and Lewy body disease (LBD) as it pertains to the use of cholinesterase inhibitors (ChEI). AD and LBD are first reviewed from clinica...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-12-01
|
| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://www.humgenomics.com/content/4/2/91 |
| _version_ | 1817991623566426112 |
|---|---|
| author | Lam Benjamin Hollingdrake Elizabeth Kennedy James L Black Sandra E Masellis Mario |
| author_facet | Lam Benjamin Hollingdrake Elizabeth Kennedy James L Black Sandra E Masellis Mario |
| author_sort | Lam Benjamin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>This review provides an update on the current state of pharmacogenetic research in the treatment of Alzheimer's disease (AD) and Lewy body disease (LBD) as it pertains to the use of cholinesterase inhibitors (ChEI). AD and LBD are first reviewed from clinical and pathophysiological perspectives. This is followed by a discussion of ChEIs used in the symptomatic treatment of these conditions, focusing on their unique and overlapping pharmacokinetic and pharmacodynamic profiles, which can be used to identify candidate genes for pharmacogenetics studies. The literature published to date is then reviewed and limitations are discussed. This is followed by a discussion of potential endophenotypes which may help to refine future pharmacogenetic studies of response and adverse effects to ChEIs.</p> |
| first_indexed | 2024-04-14T01:15:40Z |
| format | Article |
| id | doaj.art-35bf49a94ddb46779f6887e3ed1eaff0 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-14T01:15:40Z |
| publishDate | 2009-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-35bf49a94ddb46779f6887e3ed1eaff02022-12-22T02:20:51ZengBMCHuman Genomics1479-73642009-12-01429110610.1186/1479-7364-4-2-91Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic storyLam BenjaminHollingdrake ElizabethKennedy James LBlack Sandra EMasellis Mario<p>Abstract</p> <p>This review provides an update on the current state of pharmacogenetic research in the treatment of Alzheimer's disease (AD) and Lewy body disease (LBD) as it pertains to the use of cholinesterase inhibitors (ChEI). AD and LBD are first reviewed from clinical and pathophysiological perspectives. This is followed by a discussion of ChEIs used in the symptomatic treatment of these conditions, focusing on their unique and overlapping pharmacokinetic and pharmacodynamic profiles, which can be used to identify candidate genes for pharmacogenetics studies. The literature published to date is then reviewed and limitations are discussed. This is followed by a discussion of potential endophenotypes which may help to refine future pharmacogenetic studies of response and adverse effects to ChEIs.</p>http://www.humgenomics.com/content/4/2/91Alzheimer's diseasecholinesterase inhibitorsendophenotypeLewy body diseaseneuroimagingpharmacogenetics |
| spellingShingle | Lam Benjamin Hollingdrake Elizabeth Kennedy James L Black Sandra E Masellis Mario Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story Human Genomics Alzheimer's disease cholinesterase inhibitors endophenotype Lewy body disease neuroimaging pharmacogenetics |
| title | Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story |
| title_full | Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story |
| title_fullStr | Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story |
| title_full_unstemmed | Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story |
| title_short | Cholinesterase inhibitors in Alzheimer's disease and Lewy body spectrum disorders: the emerging pharmacogenetic story |
| title_sort | cholinesterase inhibitors in alzheimer s disease and lewy body spectrum disorders the emerging pharmacogenetic story |
| topic | Alzheimer's disease cholinesterase inhibitors endophenotype Lewy body disease neuroimaging pharmacogenetics |
| url | http://www.humgenomics.com/content/4/2/91 |
| work_keys_str_mv | AT lambenjamin cholinesteraseinhibitorsinalzheimersdiseaseandlewybodyspectrumdisorderstheemergingpharmacogeneticstory AT hollingdrakeelizabeth cholinesteraseinhibitorsinalzheimersdiseaseandlewybodyspectrumdisorderstheemergingpharmacogeneticstory AT kennedyjamesl cholinesteraseinhibitorsinalzheimersdiseaseandlewybodyspectrumdisorderstheemergingpharmacogeneticstory AT blacksandrae cholinesteraseinhibitorsinalzheimersdiseaseandlewybodyspectrumdisorderstheemergingpharmacogeneticstory AT masellismario cholinesteraseinhibitorsinalzheimersdiseaseandlewybodyspectrumdisorderstheemergingpharmacogeneticstory |