Research Progress on Crotonylation in Malignant Tumor
As a newly discovered posttranslational modification (PTM), crotonylation has been identified in histone and nonhistone proteins and has important roles in the regulation of various diseases and biological processes. With the development of high-resolution mass spectrometry approaches, an increasing...
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2023-02-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.0770 |
| _version_ | 1811158363223883776 |
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| author | LIU Fangyuan SU Liya |
| author_facet | LIU Fangyuan SU Liya |
| author_sort | LIU Fangyuan |
| collection | DOAJ |
| description | As a newly discovered posttranslational modification (PTM), crotonylation has been identified in histone and nonhistone proteins and has important roles in the regulation of various diseases and biological processes. With the development of high-resolution mass spectrometry approaches, an increasing number of endogenous crotonylation has been detected and identified. The discovery of crotonylation regulatory enzymes paved the way for the study of crotonylation mechanism. In this review, we summarize the biological functions and regulatory mechanism of crotonylation in eukaryotes and introduce the recent progress on crotonylation in malignant tumor. |
| first_indexed | 2024-04-10T05:23:21Z |
| format | Article |
| id | doaj.art-35bfd045571f4e52ac94089b80016bc3 |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-04-10T05:23:21Z |
| publishDate | 2023-02-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-35bfd045571f4e52ac94089b80016bc32023-03-08T05:14:03ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-02-0150219520110.3971/j.issn.1000-8578.2023.22.07708578.2023.22.0770Research Progress on Crotonylation in Malignant TumorLIU Fangyuan0SU Liya1Research Center for Clinical Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, ChinaResearch Center for Clinical Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, ChinaAs a newly discovered posttranslational modification (PTM), crotonylation has been identified in histone and nonhistone proteins and has important roles in the regulation of various diseases and biological processes. With the development of high-resolution mass spectrometry approaches, an increasing number of endogenous crotonylation has been detected and identified. The discovery of crotonylation regulatory enzymes paved the way for the study of crotonylation mechanism. In this review, we summarize the biological functions and regulatory mechanism of crotonylation in eukaryotes and introduce the recent progress on crotonylation in malignant tumor.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.0770crotonylationmalignant tumorsproteinposttranslational modification |
| spellingShingle | LIU Fangyuan SU Liya Research Progress on Crotonylation in Malignant Tumor Zhongliu Fangzhi Yanjiu crotonylation malignant tumors protein posttranslational modification |
| title | Research Progress on Crotonylation in Malignant Tumor |
| title_full | Research Progress on Crotonylation in Malignant Tumor |
| title_fullStr | Research Progress on Crotonylation in Malignant Tumor |
| title_full_unstemmed | Research Progress on Crotonylation in Malignant Tumor |
| title_short | Research Progress on Crotonylation in Malignant Tumor |
| title_sort | research progress on crotonylation in malignant tumor |
| topic | crotonylation malignant tumors protein posttranslational modification |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.0770 |
| work_keys_str_mv | AT liufangyuan researchprogressoncrotonylationinmalignanttumor AT suliya researchprogressoncrotonylationinmalignanttumor |