Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review
The transmission of infectious agents from domestic animals to humans is a matter of particular concern at present. Inoculation can enhance the defences of each individual animal but only in the short term. Certainly, it will be of immense benefit if biotechnology and genetic techniques are applied...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2013-01-01
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| Series: | Veterinární Medicína |
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| Online Access: | https://vetmed.agriculturejournals.cz/artkey/vet-201301-0001_structural-homology-and-expression-tendency-of-the-natural-immune-response-of-the-terminal-complement-component.php |
| _version_ | 1797897575006732288 |
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| author | D.V.A. Khoa |
| author_facet | D.V.A. Khoa |
| author_sort | D.V.A. Khoa |
| collection | DOAJ |
| description | The transmission of infectious agents from domestic animals to humans is a matter of particular concern at present. Inoculation can enhance the defences of each individual animal but only in the short term. Certainly, it will be of immense benefit if biotechnology and genetic techniques are applied to farm animal breeding and selection programs to improve productivity, performance and health status as well as for the construction of sustainable animal production systems and promotion of animal welfare. In recent years, efforts to drive candidate genes like cytokines, haptoglobin, complement system, C-reactive protein, a 2-macroglobulin, retinol binding protein, transcortin, and etc. associated with immune traits have successfully been studied in human and different animal species. Here, we compared the molecular structure and evaluated the expression tendency of the haemolytic complement activity (HCA) of porcine candidate genes encoding the terminal complement components (TCC) C6-9. The results suggested that (1) high homology of complement genes among mammalian species may open new ways in cure/ treatment of disease; (2) Muong Khuong animals (Vietnamese potbelly pig) have a great genetic potential to improve the health status of pigs; and (3) HCA in the classical pathway can be developed further by different activation modes, with the potential improvement of animal health. |
| first_indexed | 2024-04-10T08:00:32Z |
| format | Article |
| id | doaj.art-35c06a682c8749eb9fbabe644f626728 |
| institution | Directory Open Access Journal |
| issn | 0375-8427 1805-9392 |
| language | English |
| last_indexed | 2024-04-10T08:00:32Z |
| publishDate | 2013-01-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Veterinární Medicína |
| spelling | doaj.art-35c06a682c8749eb9fbabe644f6267282023-02-23T03:50:08ZengCzech Academy of Agricultural SciencesVeterinární Medicína0375-84271805-93922013-01-015811910.17221/6650-VETMEDvet-201301-0001Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a reviewD.V.A. Khoa0College of Agriculture and Applied Biology, Can Tho University, VietnamThe transmission of infectious agents from domestic animals to humans is a matter of particular concern at present. Inoculation can enhance the defences of each individual animal but only in the short term. Certainly, it will be of immense benefit if biotechnology and genetic techniques are applied to farm animal breeding and selection programs to improve productivity, performance and health status as well as for the construction of sustainable animal production systems and promotion of animal welfare. In recent years, efforts to drive candidate genes like cytokines, haptoglobin, complement system, C-reactive protein, a 2-macroglobulin, retinol binding protein, transcortin, and etc. associated with immune traits have successfully been studied in human and different animal species. Here, we compared the molecular structure and evaluated the expression tendency of the haemolytic complement activity (HCA) of porcine candidate genes encoding the terminal complement components (TCC) C6-9. The results suggested that (1) high homology of complement genes among mammalian species may open new ways in cure/ treatment of disease; (2) Muong Khuong animals (Vietnamese potbelly pig) have a great genetic potential to improve the health status of pigs; and (3) HCA in the classical pathway can be developed further by different activation modes, with the potential improvement of animal health.https://vetmed.agriculturejournals.cz/artkey/vet-201301-0001_structural-homology-and-expression-tendency-of-the-natural-immune-response-of-the-terminal-complement-component.phppigsterminal complement geneshomologygenetic variationand haemolytic complement activity |
| spellingShingle | D.V.A. Khoa Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review Veterinární Medicína pigs terminal complement genes homology genetic variation and haemolytic complement activity |
| title | Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review |
| title_full | Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review |
| title_fullStr | Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review |
| title_full_unstemmed | Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review |
| title_short | Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review |
| title_sort | structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs a review |
| topic | pigs terminal complement genes homology genetic variation and haemolytic complement activity |
| url | https://vetmed.agriculturejournals.cz/artkey/vet-201301-0001_structural-homology-and-expression-tendency-of-the-natural-immune-response-of-the-terminal-complement-component.php |
| work_keys_str_mv | AT dvakhoa structuralhomologyandexpressiontendencyofthenaturalimmuneresponseoftheterminalcomplementcomponentstoinoculationsinpigsareview |