Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal Health
Instant Cascara (IC) is a beverage made from dried coffee cherries, enriched in nutrients and bioactive compounds such as caffeine and other phytochemicals with a positive impact on the brain–gut axis health. The use of dried coffee cherries as novel foods in drinks was authorized by the EU in 2023....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Proceedings |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2504-3900/89/1/21 |
| _version_ | 1797577564540108800 |
|---|---|
| author | Vanesa Sánchez-Martín Marta B. López-Parra Amaia Iriondo-DeHond Ana I. Haza Paloma Morales María Dolores del Castillo |
| author_facet | Vanesa Sánchez-Martín Marta B. López-Parra Amaia Iriondo-DeHond Ana I. Haza Paloma Morales María Dolores del Castillo |
| author_sort | Vanesa Sánchez-Martín |
| collection | DOAJ |
| description | Instant Cascara (IC) is a beverage made from dried coffee cherries, enriched in nutrients and bioactive compounds such as caffeine and other phytochemicals with a positive impact on the brain–gut axis health. The use of dried coffee cherries as novel foods in drinks was authorized by the EU in 2023. The process for obtaining IC involves the concentration of the regular drink by spray-drying. Colorectal cancer, chronic gut disease, is the third most common cancer type causing 1 million deaths/year. In high-income countries, colon and rectum cancers were one of the top ten causes of death in 2019. The present research aimed to obtain novel and preliminary information about the potential prophylactic or therapeutic effect of IC on colon cancer. In vitro cell models were used to analyze its genotoxicity and effects on key physiological cell events such as intracellular ROS production, proliferation and apoptosis associated with the pathogenesis of cancer. IC was determined non-genotoxic using the comet assay, reduced ROS production in normal and cancer colon cells and selectively affected the proliferation and apoptosis of colon cancer cells by labeled annexin incorporation assay. In conclusion, our preliminary data supported the safety and potential use of IC as a sustainable promoter of gastrointestinal health. Therefore, the upcycling of dried coffee cherries into IC may contribute to the sustainability of the coffee industry and to achieving Global Sustainable Development Goals (3: “Good health and well-being” and 12: “Responsible consumption and production”). |
| first_indexed | 2024-03-10T22:10:07Z |
| format | Article |
| id | doaj.art-35c265bd2a0b4150a6cea93f12dda337 |
| institution | Directory Open Access Journal |
| issn | 2504-3900 |
| language | English |
| last_indexed | 2024-03-10T22:10:07Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proceedings |
| spelling | doaj.art-35c265bd2a0b4150a6cea93f12dda3372023-11-19T12:37:21ZengMDPI AGProceedings2504-39002023-08-018912110.3390/ICC2023-14841Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal HealthVanesa Sánchez-Martín0Marta B. López-Parra1Amaia Iriondo-DeHond2Ana I. Haza3Paloma Morales4María Dolores del Castillo5Instituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), 28049 Madrid, SpainInstituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), 28049 Madrid, SpainSección Departamental de Nutrición y Ciencia de los Alimentos, Departamento de Nutrición y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, SpainSección Departamental de Nutrición y Ciencia de los Alimentos, Departamento de Nutrición y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, SpainSección Departamental de Nutrición y Ciencia de los Alimentos, Departamento de Nutrición y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, SpainInstituto de Investigación en Ciencias de la Alimentación (CIAL) (CSIC-UAM), 28049 Madrid, SpainInstant Cascara (IC) is a beverage made from dried coffee cherries, enriched in nutrients and bioactive compounds such as caffeine and other phytochemicals with a positive impact on the brain–gut axis health. The use of dried coffee cherries as novel foods in drinks was authorized by the EU in 2023. The process for obtaining IC involves the concentration of the regular drink by spray-drying. Colorectal cancer, chronic gut disease, is the third most common cancer type causing 1 million deaths/year. In high-income countries, colon and rectum cancers were one of the top ten causes of death in 2019. The present research aimed to obtain novel and preliminary information about the potential prophylactic or therapeutic effect of IC on colon cancer. In vitro cell models were used to analyze its genotoxicity and effects on key physiological cell events such as intracellular ROS production, proliferation and apoptosis associated with the pathogenesis of cancer. IC was determined non-genotoxic using the comet assay, reduced ROS production in normal and cancer colon cells and selectively affected the proliferation and apoptosis of colon cancer cells by labeled annexin incorporation assay. In conclusion, our preliminary data supported the safety and potential use of IC as a sustainable promoter of gastrointestinal health. Therefore, the upcycling of dried coffee cherries into IC may contribute to the sustainability of the coffee industry and to achieving Global Sustainable Development Goals (3: “Good health and well-being” and 12: “Responsible consumption and production”).https://www.mdpi.com/2504-3900/89/1/21antioxidantcell proliferationcoffee fruit cascaracolon cancergenotoxicityinstant beverage |
| spellingShingle | Vanesa Sánchez-Martín Marta B. López-Parra Amaia Iriondo-DeHond Ana I. Haza Paloma Morales María Dolores del Castillo Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal Health Proceedings antioxidant cell proliferation coffee fruit cascara colon cancer genotoxicity instant beverage |
| title | Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal Health |
| title_full | Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal Health |
| title_fullStr | Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal Health |
| title_full_unstemmed | Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal Health |
| title_short | Instant Cascara: A Potential Sustainable Promoter of Gastrointestinal Health |
| title_sort | instant cascara a potential sustainable promoter of gastrointestinal health |
| topic | antioxidant cell proliferation coffee fruit cascara colon cancer genotoxicity instant beverage |
| url | https://www.mdpi.com/2504-3900/89/1/21 |
| work_keys_str_mv | AT vanesasanchezmartin instantcascaraapotentialsustainablepromoterofgastrointestinalhealth AT martablopezparra instantcascaraapotentialsustainablepromoterofgastrointestinalhealth AT amaiairiondodehond instantcascaraapotentialsustainablepromoterofgastrointestinalhealth AT anaihaza instantcascaraapotentialsustainablepromoterofgastrointestinalhealth AT palomamorales instantcascaraapotentialsustainablepromoterofgastrointestinalhealth AT mariadoloresdelcastillo instantcascaraapotentialsustainablepromoterofgastrointestinalhealth |