Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats
Abstract Background An increasing number of studies have shown that obesity is the key etiological agent of cardiovascular diseases, nonalcoholic fatty liver disease, type 2 diabetes and several kinds of cancer and that gut microbiota change was one of the reasons suffering from obesity. At present,...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-018-0910-6 |
| _version_ | 1817998585227116544 |
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| author | Yanan An Yan Li Xueyan Wang Zhaobin Chen Hongyue Xu Lingyu Wu Shulin Li Chao Wang Wenjing Luan Xuefei Wang Mingyuan Liu Xudong Tang Lu Yu |
| author_facet | Yanan An Yan Li Xueyan Wang Zhaobin Chen Hongyue Xu Lingyu Wu Shulin Li Chao Wang Wenjing Luan Xuefei Wang Mingyuan Liu Xudong Tang Lu Yu |
| author_sort | Yanan An |
| collection | DOAJ |
| description | Abstract Background An increasing number of studies have shown that obesity is the key etiological agent of cardiovascular diseases, nonalcoholic fatty liver disease, type 2 diabetes and several kinds of cancer and that gut microbiota change was one of the reasons suffering from obesity. At present, the gut microbiota has gained increased attention as a potential energy metabolism organ. Our recent study reported that cordycepin, a major bioactive component separated from Cordyceps militaris, prevented body weight gain in mice fed a high-fat diet directly acting to adipocytes, however, the effect of cordycepin regulating gut microbiota keeps unknown. Methods In this research, we synthesized cordycepin (3-deoxyadenosine) by chemical methods and verified that cordycepin reduces body weight gain and fat accumulation around the epididymis and the kidneys of rats fed a high-fat diet. Furthermore, we used high-throughput sequencing on a MiSeq Illumina platform to test the species of intestinal bacteria in high-fat-diet-induced obese rats. Results We found that cordycepin modifies the relative abundance of intestinal bacteria in high-fat-diet-induced obese rats. However, cordycepin did not alter the variety of bacteria in the intestine. Cordycepin treatment dramatically reversed the relative abundance of two dominant bacterial phyla (Bacteroidetes and Firmicutes) in the high-fat-diet-induced obese rats, resulting in abundance similar to that of the chow diet group. Conclusion Our study suggests that cordycepin can reduce body weight and microbiome done by cordycepin seems be a result among its mechanisms of obesity reduction. |
| first_indexed | 2024-04-14T02:55:31Z |
| format | Article |
| id | doaj.art-35c3932a40e6493d9b9786f35190818a |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-04-14T02:55:31Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-35c3932a40e6493d9b9786f35190818a2022-12-22T02:16:07ZengBMCLipids in Health and Disease1476-511X2018-12-0117111010.1186/s12944-018-0910-6Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese ratsYanan An0Yan Li1Xueyan Wang2Zhaobin Chen3Hongyue Xu4Lingyu Wu5Shulin Li6Chao Wang7Wenjing Luan8Xuefei Wang9Mingyuan Liu10Xudong Tang11Lu Yu12Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Lab for New Drugs Research of TCM in Shenzhen, Research Institute of Tsinghua University in ShenzhenWest China School of Public Health, Sichuan UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityKey Lab for New Drugs Research of TCM in Shenzhen, Research Institute of Tsinghua University in ShenzhenKey Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin UniversityAbstract Background An increasing number of studies have shown that obesity is the key etiological agent of cardiovascular diseases, nonalcoholic fatty liver disease, type 2 diabetes and several kinds of cancer and that gut microbiota change was one of the reasons suffering from obesity. At present, the gut microbiota has gained increased attention as a potential energy metabolism organ. Our recent study reported that cordycepin, a major bioactive component separated from Cordyceps militaris, prevented body weight gain in mice fed a high-fat diet directly acting to adipocytes, however, the effect of cordycepin regulating gut microbiota keeps unknown. Methods In this research, we synthesized cordycepin (3-deoxyadenosine) by chemical methods and verified that cordycepin reduces body weight gain and fat accumulation around the epididymis and the kidneys of rats fed a high-fat diet. Furthermore, we used high-throughput sequencing on a MiSeq Illumina platform to test the species of intestinal bacteria in high-fat-diet-induced obese rats. Results We found that cordycepin modifies the relative abundance of intestinal bacteria in high-fat-diet-induced obese rats. However, cordycepin did not alter the variety of bacteria in the intestine. Cordycepin treatment dramatically reversed the relative abundance of two dominant bacterial phyla (Bacteroidetes and Firmicutes) in the high-fat-diet-induced obese rats, resulting in abundance similar to that of the chow diet group. Conclusion Our study suggests that cordycepin can reduce body weight and microbiome done by cordycepin seems be a result among its mechanisms of obesity reduction.http://link.springer.com/article/10.1186/s12944-018-0910-6CordycepinGut microbiotaObesityBody weightFat |
| spellingShingle | Yanan An Yan Li Xueyan Wang Zhaobin Chen Hongyue Xu Lingyu Wu Shulin Li Chao Wang Wenjing Luan Xuefei Wang Mingyuan Liu Xudong Tang Lu Yu Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats Lipids in Health and Disease Cordycepin Gut microbiota Obesity Body weight Fat |
| title | Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats |
| title_full | Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats |
| title_fullStr | Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats |
| title_full_unstemmed | Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats |
| title_short | Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats |
| title_sort | cordycepin reduces weight through regulating gut microbiota in high fat diet induced obese rats |
| topic | Cordycepin Gut microbiota Obesity Body weight Fat |
| url | http://link.springer.com/article/10.1186/s12944-018-0910-6 |
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