Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in
The efficacy of cardiotonic drugs on the energy supply system and bioenergetic processes in failing myocardium under severe form heart failure (HF) coupled with systemic inflammatory response syndrom, has been studied in the randomized, controlled trial. It has been shown, that treatment with cardio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-02-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/449 |
| _version_ | 1797295531458822144 |
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| author | D. I. Ionov M. M. Fedorova P. A. Galenko-Yaroshevsky T. D. Kezeli M. A. Mirziashvili M. D. Chipashvili G. V. Sukoyan |
| author_facet | D. I. Ionov M. M. Fedorova P. A. Galenko-Yaroshevsky T. D. Kezeli M. A. Mirziashvili M. D. Chipashvili G. V. Sukoyan |
| author_sort | D. I. Ionov |
| collection | DOAJ |
| description | The efficacy of cardiotonic drugs on the energy supply system and bioenergetic processes in failing myocardium under severe form heart failure (HF) coupled with systemic inflammatory response syndrom, has been studied in the randomized, controlled trial. It has been shown, that treatment with cardioprotector (NAD- and cardiac glycoside-containing) drug Adenocin® unlike inhibitors of phosphodiesterase, amrinone and levosimendan, abolished the progression of bioenergetics failure and mitochondrial remodeling. Adenocin® occurs restoration of level of redox-potential NAD/NADH and cessates the release of cytochrome C from the mitochondries of cardiomyocyte. HF increased the content of ATP and creatinphosphate in left and right ventricle of myocardium, and restored the level of redox-potential NAD/NADH and cytochrome in mitochondria of cardiomyocytes, that leads in the basis of sharply decrease of ATP and creatinphosphate in myocardium, switch the lactate/pyruvate ratio to the increase of pyruvate (aerobic glycolysis). The linear positive correlation between redox-potential NAD/NADH in ventricular myocardium and blood and negative between level of cytochrome C in myocardium and blood has been shown. |
| first_indexed | 2024-03-07T21:50:14Z |
| format | Article |
| id | doaj.art-35c59cfd2a5e49eab9096dd2d5d988ec |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:50:14Z |
| publishDate | 2016-02-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-35c59cfd2a5e49eab9096dd2d5d988ec2024-02-25T10:57:17ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-02-011525610.25207/1608-6228-2016-1-52-56449Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms inD. I. Ionov0M. M. Fedorova1P. A. Galenko-Yaroshevsky2T. D. Kezeli3M. A. Mirziashvili4M. D. Chipashvili5G. V. Sukoyan6Kuban state medical universityRussian academy of postgraduate study Ministry of health and social developmentKuban state medical universityI. Javakhishvili Tbilisi state universityI. Javakhishvili Tbilisi state universityI. Javakhishvili Tbilisi state universityI. Javakhishvili Tbilisi state universityThe efficacy of cardiotonic drugs on the energy supply system and bioenergetic processes in failing myocardium under severe form heart failure (HF) coupled with systemic inflammatory response syndrom, has been studied in the randomized, controlled trial. It has been shown, that treatment with cardioprotector (NAD- and cardiac glycoside-containing) drug Adenocin® unlike inhibitors of phosphodiesterase, amrinone and levosimendan, abolished the progression of bioenergetics failure and mitochondrial remodeling. Adenocin® occurs restoration of level of redox-potential NAD/NADH and cessates the release of cytochrome C from the mitochondries of cardiomyocyte. HF increased the content of ATP and creatinphosphate in left and right ventricle of myocardium, and restored the level of redox-potential NAD/NADH and cytochrome in mitochondria of cardiomyocytes, that leads in the basis of sharply decrease of ATP and creatinphosphate in myocardium, switch the lactate/pyruvate ratio to the increase of pyruvate (aerobic glycolysis). The linear positive correlation between redox-potential NAD/NADH in ventricular myocardium and blood and negative between level of cytochrome C in myocardium and blood has been shown.https://ksma.elpub.ru/jour/article/view/449сердечная недостаточностькардиотонические средствабиоэнергетическая недостаточностьредокс-потенциалцитохром сheart failurecardiotonic drugbioenergetics failureredox-potentialcytochrome c |
| spellingShingle | D. I. Ionov M. M. Fedorova P. A. Galenko-Yaroshevsky T. D. Kezeli M. A. Mirziashvili M. D. Chipashvili G. V. Sukoyan Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in Кубанский научный медицинский вестник сердечная недостаточность кардиотонические средства биоэнергетическая недостаточность редокс-потенциал цитохром с heart failure cardiotonic drug bioenergetics failure redox-potential cytochrome c |
| title | Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in |
| title_full | Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in |
| title_fullStr | Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in |
| title_full_unstemmed | Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in |
| title_short | Efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in |
| title_sort | efficacy cardiotonic medicines on the bioenergetic processes and endothelial dysfunction under coupled of heart failure and systemic inflammatory syndroms in |
| topic | сердечная недостаточность кардиотонические средства биоэнергетическая недостаточность редокс-потенциал цитохром с heart failure cardiotonic drug bioenergetics failure redox-potential cytochrome c |
| url | https://ksma.elpub.ru/jour/article/view/449 |
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