Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors.
Metabolic reprogramming is associated with tumorigenesis. However, glucose metabolism in tumors is poorly understood. Here, we report that glucose levels are significantly lower in bulk tumor specimens than those in normal tissues of the same tissue origins. We show that mono-ubiquitinated histone H...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3353945?pdf=render |
| _version_ | 1818213419006820352 |
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| author | Yasuyo Urasaki Linda Heath C Wilson Xu |
| author_facet | Yasuyo Urasaki Linda Heath C Wilson Xu |
| author_sort | Yasuyo Urasaki |
| collection | DOAJ |
| description | Metabolic reprogramming is associated with tumorigenesis. However, glucose metabolism in tumors is poorly understood. Here, we report that glucose levels are significantly lower in bulk tumor specimens than those in normal tissues of the same tissue origins. We show that mono-ubiquitinated histone H2B (uH2B) is a semi-quantitative histone marker for glucose. We further show that loss of uH2B occurs specifically in cancer cells from a wide array of tumor specimens of breast, colon, lung and additional 23 anatomic sites. In contrast, uH2B levels remain high in stromal tissues or non-cancerous cells in the tumor specimens. Taken together, our data suggest that glucose deficiency and loss of uH2B are novel properties of cancer cells in vivo, which may represent important regulatory mechanisms of tumorigenesis. |
| first_indexed | 2024-12-12T06:03:59Z |
| format | Article |
| id | doaj.art-35c86bfdf25b41e3b1929144a135e97c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T06:03:59Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-35c86bfdf25b41e3b1929144a135e97c2022-12-22T00:35:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0175e3677510.1371/journal.pone.0036775Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors.Yasuyo UrasakiLinda HeathC Wilson XuMetabolic reprogramming is associated with tumorigenesis. However, glucose metabolism in tumors is poorly understood. Here, we report that glucose levels are significantly lower in bulk tumor specimens than those in normal tissues of the same tissue origins. We show that mono-ubiquitinated histone H2B (uH2B) is a semi-quantitative histone marker for glucose. We further show that loss of uH2B occurs specifically in cancer cells from a wide array of tumor specimens of breast, colon, lung and additional 23 anatomic sites. In contrast, uH2B levels remain high in stromal tissues or non-cancerous cells in the tumor specimens. Taken together, our data suggest that glucose deficiency and loss of uH2B are novel properties of cancer cells in vivo, which may represent important regulatory mechanisms of tumorigenesis.http://europepmc.org/articles/PMC3353945?pdf=render |
| spellingShingle | Yasuyo Urasaki Linda Heath C Wilson Xu Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors. PLoS ONE |
| title | Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors. |
| title_full | Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors. |
| title_fullStr | Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors. |
| title_full_unstemmed | Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors. |
| title_short | Coupling of glucose deprivation with impaired histone H2B monoubiquitination in tumors. |
| title_sort | coupling of glucose deprivation with impaired histone h2b monoubiquitination in tumors |
| url | http://europepmc.org/articles/PMC3353945?pdf=render |
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