Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq
Antimicrobial resistance (AMR) is a serious challenge for infectious disease prevention and treatment, according to the World Health Organization. It is a worldwide problem caused primarily by inappropriate and insufficient therapy, misuse of antimicrobials without physician supervision, unnecessary...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Razi Vaccine and Serum Research Institute
2022-02-01
|
| Series: | Archives of Razi Institute |
| Subjects: | |
| Online Access: | https://archrazi.areeo.ac.ir/article_125923_643de20a7ea349b374182b80d21484b1.pdf |
| _version_ | 1817976385670479872 |
|---|---|
| author | Huda Abdul-Mohammed Al-Rawazq A Kamal Mohammed Z Mohsen Ahmed |
| author_facet | Huda Abdul-Mohammed Al-Rawazq A Kamal Mohammed Z Mohsen Ahmed |
| author_sort | Huda Abdul-Mohammed Al-Rawazq |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) is a serious challenge for infectious disease prevention and treatment, according to the World Health Organization. It is a worldwide problem caused primarily by inappropriate and insufficient therapy, misuse of antimicrobials without physician supervision, unnecessary hospital readmissions, and other factors. AMR has several consequences, including increased medical costs and mortality. The present study aimed to evaluate imipenem resistance in gram-negative bacteria in Central Pediatric Teaching Hospital in Baghdad, Iraq, and determine this bacteria resistance in different samples. Initially, a total of 100 different samples were collected from child patients from October 1, 2020, to August 31, 2021. Each isolate was identified using VITEK 2 automated microbiology system. The recorded data showed that the isolated organisms resistant to imipenem included Klebsiella pneumonia (n=21), Pseudomonas aeruginosa (n=19), and Acinetobacter baumannii (n=16). In the current study, Klebsiella pneumonia was the most common pathogen in males (n=57) compared to female (n=43), followed by Pseudomonas aeruginosa and Acinetobacter baumannii, particularly in the age range of 1 day- 3 years. Depending on the sample type, Klebsiella pneumonia, the most imipenem-resistant bacteria, was found more in the urine of patients with urinary tract infections. Pseudomonas aeruginosa was equally found in blood, urine, wound swab, and sputum samples. In comparison to other samples, Acinetobacter baumannii was found in greater numbers in the blood and in an equal number in urine and cerebrospinal. |
| first_indexed | 2024-04-13T22:02:52Z |
| format | Article |
| id | doaj.art-35c8dd28430f41e29e47afb2b2b3e30b |
| institution | Directory Open Access Journal |
| issn | 0365-3439 2008-9872 |
| language | English |
| last_indexed | 2024-04-13T22:02:52Z |
| publishDate | 2022-02-01 |
| publisher | Razi Vaccine and Serum Research Institute |
| record_format | Article |
| series | Archives of Razi Institute |
| spelling | doaj.art-35c8dd28430f41e29e47afb2b2b3e30b2022-12-22T02:28:02ZengRazi Vaccine and Serum Research InstituteArchives of Razi Institute0365-34392008-98722022-02-0177112312810.22092/ari.2021.356678.1891125923Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, IraqHuda Abdul-Mohammed Al-Rawazq0A Kamal Mohammed1Z Mohsen Ahmed2Anatomy -Biology section, College of Medicine, University of Baghdad, Baghdad,IraqCentral Pediatric Teaching Hospital, Baghdad, IraqCentral Pediatric Teaching Hospital, Baghdad, IraqAntimicrobial resistance (AMR) is a serious challenge for infectious disease prevention and treatment, according to the World Health Organization. It is a worldwide problem caused primarily by inappropriate and insufficient therapy, misuse of antimicrobials without physician supervision, unnecessary hospital readmissions, and other factors. AMR has several consequences, including increased medical costs and mortality. The present study aimed to evaluate imipenem resistance in gram-negative bacteria in Central Pediatric Teaching Hospital in Baghdad, Iraq, and determine this bacteria resistance in different samples. Initially, a total of 100 different samples were collected from child patients from October 1, 2020, to August 31, 2021. Each isolate was identified using VITEK 2 automated microbiology system. The recorded data showed that the isolated organisms resistant to imipenem included Klebsiella pneumonia (n=21), Pseudomonas aeruginosa (n=19), and Acinetobacter baumannii (n=16). In the current study, Klebsiella pneumonia was the most common pathogen in males (n=57) compared to female (n=43), followed by Pseudomonas aeruginosa and Acinetobacter baumannii, particularly in the age range of 1 day- 3 years. Depending on the sample type, Klebsiella pneumonia, the most imipenem-resistant bacteria, was found more in the urine of patients with urinary tract infections. Pseudomonas aeruginosa was equally found in blood, urine, wound swab, and sputum samples. In comparison to other samples, Acinetobacter baumannii was found in greater numbers in the blood and in an equal number in urine and cerebrospinal.https://archrazi.areeo.ac.ir/article_125923_643de20a7ea349b374182b80d21484b1.pdfchildrendifferent samplesgram-negative bacteriaimipenem antibiotic |
| spellingShingle | Huda Abdul-Mohammed Al-Rawazq A Kamal Mohammed Z Mohsen Ahmed Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq Archives of Razi Institute children different samples gram-negative bacteria imipenem antibiotic |
| title | Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq |
| title_full | Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq |
| title_fullStr | Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq |
| title_full_unstemmed | Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq |
| title_short | Imipenem Resistance in Gram-Negative Bacteria in the Central Pediatric Teaching Hospital in Baghdad, Iraq |
| title_sort | imipenem resistance in gram negative bacteria in the central pediatric teaching hospital in baghdad iraq |
| topic | children different samples gram-negative bacteria imipenem antibiotic |
| url | https://archrazi.areeo.ac.ir/article_125923_643de20a7ea349b374182b80d21484b1.pdf |
| work_keys_str_mv | AT hudaabdulmohammedalrawazq imipenemresistanceingramnegativebacteriainthecentralpediatricteachinghospitalinbaghdadiraq AT akamalmohammed imipenemresistanceingramnegativebacteriainthecentralpediatricteachinghospitalinbaghdadiraq AT zmohsenahmed imipenemresistanceingramnegativebacteriainthecentralpediatricteachinghospitalinbaghdadiraq |